NCT03939260

ECCO2R - Mechanical Power Study

The Effects of Low Flow Extracorporeal CO2 Removal on Mechanical Power in ARDS Patients

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 15 (estimated)
• Sponsor: University of Milan · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Although mechanical ventilation remains the cornerstone of ARDS treatment, several experimental and clinical studies have undoubtedly demonstrated that it can contribute to high mortality through the developing of ventilator induced lung injury even in patients with plateau pressure \<30 cmH2O. Since now there are no studies exploring the application of low flow extracorporeal CO2 removal and ultraprotective ventilation to reduce mechanical power, a composite index of VILI, independently from the value of plateau pressure or the severity of hypercapnia.

Conditions

• ARDS, Human
• Extracorporeal CO2 Removal
• Mechanical Power

Interventions

Type	Name	Description
OTHER	Extracorporeal CO2 Removal	Extracorporeal carbon dioxide removal (ECCO2R), a low flow extracorporeal CO2 removal, may be used in association with ultraprotective mechanical ventilation (tidal volume \< 6 ml/kg and Pplat \<20-25 cmH2O).

Timeline

• Start date: 2019-03-20
• Primary completion: 2021-03-01
• Completion: 2024-03-01
• First posted: 2019-05-06
• Last updated: 2019-05-06

Locations

1 site across 1 country: Italy