NCT05847634

Depth of Sedation and Its Impact on Cerebrovascular Reactivity in Acute Respiratory Distress Syndrome: a Pilot Analysis

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: University of Manitoba · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Investigation of the feasibility of monitoring processed transcutaneous electroencephalography (EEG), a method of interpreting brain activity, and near-infrared spectroscopy (NIRS), a method of determining levels of tissue oxygenation (StO2) in the brain, for patients with acute respiratory distress syndrome (ARDS) in the ICU.

Detailed description

The aim of this study is to determine the feasibility of using Masimo SedLine processed EEG monitoring and Masimo O3 NIRS to monitor optimal depth of sedation for patients with ARDS in the ICU. To achieve this, non-invasive devices will be applied to the participant to measure processed EEG signal and StO2. Cerebrovascular reactivity will be determined using the following two values: 1. SEDopt: The optimal depth of sedation that minimizes correlation between StO2 and processed EEG monitoring. 2. MAPopt: The optimal blood pressure that minimizes correlation between StO2 and MAP. Demographic information (age, sex, height, weight), past medical history, etiology of ARDS, Disease severity, routine bloodwork, and dose of sedation will also be documented.

Conditions

• ARDS, Human

Interventions

Type	Name	Description
DEVICE	Masimo O3 NIRS cerebral oximetry and SedLine processed EEG	Non-invasive neuromonitoring device for observational study

Timeline

• Start date: 2024-11-25
• Primary completion: 2026-01-01
• Completion: 2026-01-01
• First posted: 2023-05-06
• Last updated: 2024-12-06

Locations

1 site across 1 country: Canada