Trials / Completed
CompletedNCT06197256
Cardiac Dysfunction in Critically Ill Covid-19 Patients
Right and Left Ventricular Dysfunction in Critically Ill COVID-19 Patients and the Effects of Inhaled Nitric Oxide: A Sub-study of a Prospective Randomized Controlled Trial
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 39 (actual)
- Sponsor
- Region Stockholm · Other Government
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
We conducted an observation sub-study of the prospective randomized controlled trial "High Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure", in which we analysed the echocardiographic data collected both at baseline when patients where included and 3-5 days later for followup.
Detailed description
We conducted an observation sub-study of the prospective randomized controlled trial "High Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure" which was conducted in 2020/2021 during the COVID-19 pandemic on patients with ARDS due to COVID and requiring mechanical ventialtion. Patients underwent echocardiography at baseline, and were then randomized either to control, or treatment with inhaled nitric oxide, starting at 80ppm and then 40ppm. Followup echocardiography was performed 3-5 days later, and all echocardiographies were conducted by highly experienced sonographeres certified by the European Association of Cardiovascular Imaging. Analysis of these cardiac ultrasounds focused on the amount of patients showing signs of pulmonary hypertension, right ventricular failure and left ventricular failure. Several parameters were used to estimate these, and we also aimed to evalute the utility of more novel measures such as RV and LV GLS for this use in the ICU.
Conditions
- COVID-19
- ARDS, Human
- Cardiac Failure
- Right Ventricular Dysfunction
- Left Ventricular Dysfunction
- Pulmonary Hypertension
Timeline
- Start date
- 2020-05-07
- Primary completion
- 2021-02-11
- Completion
- 2021-02-11
- First posted
- 2024-01-09
- Last updated
- 2024-01-09
Locations
1 site across 1 country: Sweden
Source: ClinicalTrials.gov record NCT06197256. Inclusion in this directory is not an endorsement.