| Not Yet Recruiting | Conventional Ultrafiltration Versus Dilutional Ultrafiltration in Pediatric CPB Patients NCT07221630 | Akron Children's Hospital | — |
| Not Yet Recruiting | A Comparative Study Between Dexmedetomidine Versus Methylprednisolone on Induced Inflammatory Response in Pati NCT07101367 | Ain Shams University | Phase 1 / Phase 2 |
| Not Yet Recruiting | Inflammatory Response and Oxidative Stress in Cardiac Surgery: Min. Invasive vs. Conventional Extracorporeal C NCT06477757 | University Medical Centre Maribor | N/A |
| Recruiting | Protective Effect of Sivelestat Against Negative Pulmonary Function and Organ Dysfunction After Cardiovascular NCT06195267 | Nanjing Medical University | N/A |
| Recruiting | Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock NCT05969275 | Ottawa Hospital Research Institute | Phase 2 |
| Recruiting | Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic Shock NCT06122987 | Kingman Regional Medical Center | Phase 4 |
| Completed | Phase 1b MMV367 PK/PD and Safety in Healthy Adult Volunteers Experimentally Infected With Blood Stage P. Falci NCT05979207 | Medicines for Malaria Venture | Phase 1 |
| Completed | Perioperative Blood Adiponectin Dynamics and Systemic Infflamatory Response After Major Colorectal Surgery NCT06057207 | Osijek University Hospital | — |
| Recruiting | Cell Therapy With Treg Cells Obtained From Thymic Tissue (thyTreg) to Control the Immune Hyperactivation Assoc NCT06052436 | Hospital General Universitario Gregorio Marañon | Phase 1 / Phase 2 |
| Recruiting | Determinants of Vascular Leakage During Systemic Inflammatory Response Syndrome NCT05663216 | Assistance Publique - Hôpitaux de Paris | — |
| Unknown | Clinical Efficacy of Indomethacin in Early Treatment of Acute Pancreatitis NCT05637281 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Unknown | European Registry for Hemadsorption in Sepsis With the Seraph Filter NCT05608096 | Croatian Society for Organ Support | — |
| Completed | Registry for Hemoperfusion of Covid-19 ICU Patients NCT05470907 | Croatian Society for Organ Support | — |
| Completed | Dynamics of microRNA Expression and Systemic Inflammatory Response in POCD After Cardiac Surgery NCT07231731 | Osijek University Hospital | — |
| Recruiting | AOrtic Surgery: Systemic Inflammatory Response Versus Sepsis NCT06028789 | University Hospital Hradec Kralove | — |
| Unknown | The Effects of Gut Micribiota Disruption on the Immune Response After Open Heart Surgery NCT03939273 | Radboud University Medical Center | N/A |
| Completed | Perioperative Sitagliptin Medication for Reduction of the Inflammatory Response Associated With Cardiopulmonar NCT05725798 | University Hospital Muenster | — |
| Recruiting | Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy NCT05172739 | University of Crete | Phase 4 |
| Unknown | Systemic and Peritoneal Inflammatory Response In Robotic-assisted And Laparoscopic Surgery for Colon Cancer NCT04687384 | University of Southern Denmark | N/A |
| Completed | ED Tracking Sheet Implementation NCT05213923 | Dartmouth-Hitchcock Medical Center | N/A |
| Completed | A Study of Auxora in Patients With Acute Pancreatitis and Accompanying SIRS NCT04681066 | CalciMedica, Inc. | Phase 2 |
| Completed | Bacterial Translocation Markers as Predictors of Infectious and Inflammatory Complications in Acute Bowel Obst NCT05229822 | Karaganda Medical University | — |
| Recruiting | Extracorporeal Blood Purification Therapy in Critically Ill Patients (GlobalARRT) NCT04580680 | Careggi Hospital | — |
| Completed | Steroid Treatment After Resuscitated Out-of-Hospital Cardiac Arrest NCT04624776 | Christian Hassager | Phase 2 |
| Completed | Near Patient Molecular Testing in Sepsis NCT05469048 | Immunexpress | — |
| Completed | Evaluation of Corticosteroid in Systemic Inflammatory Response Syndrome NCT03876041 | Assiut University | Phase 4 |
| Recruiting | Use of EBPT in Critically Ill Patients With AKI and/or Multiorgan Failure NCT04033224 | Careggi Hospital | — |
| Active Not Recruiting | Development of a Web-based Multicenter Registry on the Use of oXiris Membrane for EBPTs in Critically Ill Pati NCT03807414 | Careggi Hospital | — |
| Completed | IL-6 Inhibition for Modulating Inflammation After Cardiac Arrest NCT03863015 | Christian Hassager | Phase 2 |
| Unknown | Prognostic Value of CD64 Marker for Patients in Intensive Care Unit NCT03617796 | Central Hospital, Nancy, France | — |
| Completed | Serum Level of Lipopolysaccharide-binding Protein (LBP) and Atherosclerosis in Hemodialysis Patients NCT03427307 | Tungs' Taichung Metroharbour Hospital | — |
| Completed | CM4620 Injectable Emulsion Versus Supportive Care in Patients With Acute Pancreatitis and SIRS NCT03401190 | CalciMedica, Inc. | Phase 2 |
| Unknown | Cellular Immunotherapy for Septic Shock NCT03369275 | Ottawa Hospital Research Institute | Phase 2 |
| Terminated | Peripheral Venous Analysis (PIVA) for Predicting Volume Responsiveness and Fluid Status NCT03407287 | Vanderbilt University Medical Center | — |
| Completed | The Role of Myristic Acid in Serum for Early Diagnosis of Sepsis and Comparison With Selected Biomarkers of Se NCT03314831 | Charles University, Czech Republic | — |
| Completed | High vs Low Dose Dexamethasone on Complications in the Immediate Postoperative Phase After Mastectomy NCT03125941 | Rigshospitalet, Denmark | Phase 4 |
| Completed | Feeding the Critically Ill During Phases of Altered Redox Status NCT03085615 | University of Illinois at Chicago | N/A |
| Completed | Persistent Multiorgan Failure in Intensive Care Units NCT03604731 | Research Institute for Complex Problems of Cardiovascular Diseases, Russia | — |
| Unknown | Impact of Vitamin D Supplementation on Hepcidin Levels and Transfusion Requirements in Surgical and Septic Pat NCT03001687 | Iuliu Hatieganu University of Medicine and Pharmacy | N/A |
| Unknown | Immunophenotyping of Patients With Postoperative SIRS NCT02957175 | University of Bonn | — |
| Completed | Myeloid-Derived Supressor Cells in Cardiac Surgery Patients NCT02902939 | Research Institute for Complex Problems of Cardiovascular Diseases, Russia | N/A |
| Completed | Increased Adsorption Membranes During Cardiopulmonary Bypass NCT02518087 | Hospital Universitari de Bellvitge | N/A |
| Unknown | Immunomodulation of EA-230 Following On-pump Coronary Artery Bypass Grafting (CABG) NCT03145220 | Radboud University Medical Center | Phase 2 |
| Completed | Studying Complement Inhibition in Complex Cardiac Surgery NCT02866825 | InflaRx GmbH | Phase 2 |
| Completed | Procalcitonin (PCT) as a Diagnostic Marker of Bacterial Infection in the Patients Admitted for Fever and/or In NCT02898948 | Centre Hospitalier Universitaire, Amiens | — |
| Completed | Study to Obtain Blood and Voided Urine Samples to Improve the Diagnosis of Melioidosis NCT02668406 | Institute of Tropical Medicine, Belgium | — |
| Completed | Impact of Specific Antimicrobials and MIC Values on the Outcome of Bloodstream Infections Due to ESBL- or Carb NCT02852902 | Spanish Network for Research in Infectious Diseases | — |
| Completed | Platelets as Regulators of Inflammation in Cardiac Surgery NCT02568410 | Duke University | — |
| Completed | Can Biomarkers Aid in the Prediction of Postoperative Pain and Circulatory Instability After Major Abdominal S NCT02563652 | St. Olavs Hospital | — |
| Completed | Safety and Efficacy of Adding Intravenous N-acetyl Cysteine in Colon Surgeries NCT03589495 | Ain Shams University | Phase 4 |
| Recruiting | Clinical Microbial Species & Antibiotic Resistance ID in ED Patients Presenting With Infection - is Rapid ID P NCT01904188 | Michigan State University | — |
| Completed | Pharmacokinetics of Two Different High-dose Regimens of Intravenous Vitamin C in Critically Ill Patients NCT02455180 | Amsterdam UMC, location VUmc | Phase 4 |
| Completed | Optimal Oxygenation in the Intensive Care Unit NCT02321072 | Amsterdam UMC, location VUmc | Phase 4 |
| Completed | MicroRNA Diagnostics in Subarachnoid Hemorrhage 2 NCT02320539 | Rigshospitalet, Denmark | — |
| Completed | PPV to Guide Fluid Management in the PICU NCT02308371 | University of North Carolina, Chapel Hill | N/A |
| Unknown | Cholinergic Anti-inflammatory Pathway in Prevention & Treatment of the SIRS in Patients With Jaundice After Op NCT02279147 | Wanqing Gu | Phase 1 / Phase 2 |
| Completed | Effect of Education on Resident Physician Knowledge of Sepsis NCT02927054 | University of Utah | N/A |
| Completed | Effect of TEAS on the Incidence Rate of SIRS in Patients Undergoing Abdominal Surgery NCT02193477 | Air Force Military Medical University, China | N/A |
| Unknown | The Predictive Effect of the Inflammatory Response on the Evacuation of Mechanical Ventilation and the Mechani NCT02820090 | Beijing Chao Yang Hospital | — |
| Completed | The Importance of Albumin Infusion Rate for Plasma Volume Expansion Following Major Abdominal Surgery NCT02728921 | Region Skane | Phase 4 |
| Recruiting | Modulation of Molecular Fingerprinting in Pediatric Sepsis NCT02055105 | Phoenix Children's Hospital | — |
| Completed | Influence of Age, Sepsis and SLCO1A2 Polymorphisms on Rocuronium Pharmacokinetics NCT02399397 | Universidade Estadual Paulista Júlio de Mesquita Filho | Phase 4 |
| Completed | Endothelial Microparticles as a Biomarker for Diagnosis and Prognosis in Early Sepsis NCT01998139 | Weill Medical College of Cornell University | — |
| Completed | The Effect of Protein and Resistance Training on Muscle Mass in Acutely Ill Old Medical Patients NCT02077491 | Hvidovre University Hospital | N/A |
| Completed | Effects of Free Fatty Acids and 3-hydroxybutyrate on Protein, Glucose, Lipid Metabolism and Intracellular Sign NCT01752348 | University of Aarhus | N/A |
| Completed | IL8 Monitoring and Its Correlation With 251-gene Polymorphism NCT01708759 | Tanta University | — |
| Completed | Inflammatory Response in Aortic Valve Replacement NCT02324140 | Insel Gruppe AG, University Hospital Bern | — |
| Completed | Autonomic Nervous Activity During the Systemic Inflammatory Response in Trained and Untrained Healthy Voluntee NCT01592526 | Rigshospitalet, Denmark | EARLY_Phase 1 |
| Terminated | Cerebral Autoregulation in Non Neurological Critical Patients. NCT01731106 | Althaia Xarxa Assistencial Universitària de Manresa | — |
| Withdrawn | High Cut Off Dialysis in Systemic Inflammatory Response Syndrome Patients After Cardiac Surgery NCT01579396 | Vantive Health LLC | N/A |
| Terminated | Accuracy of Pulse Pressure Variations Measured by a Non Invasive Digital Device to Predict Fluid Responsivenes NCT03066388 | University Hospital, Lille | N/A |
| Completed | Vitamin D and Critically Ill Patients NCT01636232 | Chinese PLA General Hospital | — |
| Unknown | Alpha-1-acid Glycoprotein as a Biomarker of Developmental Diagnosing and Monitoring Effectiveness in Sepsis NCT01838525 | Chinese PLA General Hospital | — |
| Completed | Corticosteroid Prophylaxis on the Cardiopulmonary Bypass-Induced Systemic Inflammatory Response NCT01296074 | Beijing Anzhen Hospital | N/A |
| Terminated | Goal-directed Resuscitative Interventions During Pediatric Inter-facility Transport (The GRIPIT Trial) NCT01293500 | Arkansas Children's Hospital Research Institute | N/A |
| Completed | Bicarbonate and Lipocalin in Systemic Inflammatory Response Syndrome (SIRS) Study NCT00706771 | Austin Health | Phase 2 |
| Completed | INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery NCT01020409 | Medical University of Gdansk | — |
| Unknown | Hemodynamic Evaluation of Preload Responsiveness in Children by Using PiCCO NCT01157299 | Hospital Universitario La Paz | — |
| Completed | Comparison the Value of Several Biomarkers of Sepsis NCT01388725 | Chinese PLA General Hospital | — |
| Completed | Systemic Inflammation Versus Acute Pain in Total Knee Arthroplasty (TKA) NCT01322074 | Hvidovre University Hospital | — |
| Unknown | Thromboelastography in in Patients With Sepsis NCT00994877 | Assaf-Harofeh Medical Center | — |
| Terminated | Study of Albumin to Reduce Inflammation Following Surgery NCT00773110 | Imperial College London | Phase 2 |
| Withdrawn | A Pilot Study to Evaluate the Systemic Inflammatory Response of Thoracoabdominal Aortic Aneurysm Repair. NCT00739557 | The University of Texas Health Science Center, Houston | — |
| Unknown | Leptin: a Therapeutic Option for Treating Catabolic States and Malnutrition in Critically Ill Patients NCT00893932 | Hadassah Medical Organization | — |
| Unknown | Effect of Menstrual Cycle on Traumatic Systemic Response NCT03283345 | Kocaeli University | N/A |
| Terminated | Efficacy of Macrolide Immunomodulation in Severe Sepsis. NCT00708799 | VA Office of Research and Development | Phase 2 |
| Completed | Towards a High-fat Feeding Intervention Study: Identification of Markers for Inflammation and Organ Damage NCT00519350 | Maastricht University Medical Center | — |
| Unknown | Steroids In caRdiac Surgery Trial (SIRS Trial) NCT00427388 | Population Health Research Institute | Phase 4 |
| Completed | Influence of Hydrocortisone on Immunologic Markers and Health Care Related Quality of Life in Patients After C NCT00490828 | Ludwig-Maximilians - University of Munich | Phase 4 |
| Completed | The Utility of Ischemia Modified Albumin (IMA) in Sepsis NCT00448968 | Inverness Medical Innovations | — |
| Completed | Dressing: Frequency of Change and Evaluation of an Antiseptic-Impregnated Catheter Dressing in ICU Patients NCT00417235 | University Hospital, Grenoble | Phase 4 |
| Unknown | Cysteine Supplementation in Critically Ill Neonates NCT00254176 | University of California, Los Angeles | Phase 2 / Phase 3 |
| Completed | Dexamethasone for Cardiac Surgery Trial NCT00293592 | UMC Utrecht | N/A |
| Completed | Inflammatory Response During Anesthesia and Surgery NCT00356746 | UMC Utrecht | — |
| Completed | A Study in Critically Ill Patients Investigating Tolerability and Efficacy of Low-volume Pharmaconutrition (In NCT01167075 | Hannover Medical School | N/A |
| Completed | The Importance of Adrenomedullin (AM) on ACTH-Cortisol-Glucose Axis NCT00459511 | University of Sao Paulo | — |
| Completed | Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response S NCT00219375 | Ono Pharmaceutical Co., Ltd. | Phase 4 |
| Terminated | High Cut-Off Continuous Veno-venous Hemodialysis (CVVHD) in Patients Treated for Acute Renal Failure After Sys NCT00875888 | Vantive Health LLC | N/A |
| Completed | Intramedullary Femoral Reaming, Human Study NCT01042132 | Ullevaal University Hospital | N/A |
| Completed | Pilot Study of the Utility of Empiric Antibiotic Therapy for Suspected ICU-Acquired Infection NCT00438269 | Canadian Critical Care Trials Group | Phase 2 |
| Terminated | Cleansing of Suction Blood in Cardiac Surgery for Reduced Inflammatory Response NCT00159926 | Rigshospitalet, Denmark | Phase 3 |
| Completed | Safety and Efficacy of PHP in the Treatment of Shock Associated With Systemic Inflammatory Response Syndrome ( NCT00021502 | Apex Bioscience | Phase 3 |
| Completed | Biseko Versus Albumin in Systemic Inflammatory Response Syndrome (SIRS) Patients NCT00708747 | Medical University of Vienna | Phase 4 |