| Recruiting | Single Ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of LAI MMV055 Alone and in Malaria, Falciparum | Phase 1 | 2025-06-30 |
| Completed | Single Ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of MMV371 LAI in Healthy P Malaria,Falciparum | Phase 1 | 2024-08-27 |
| Completed | Radical Cure (RC) With Tafenoquine or Primaquine After Semi-quantitative G6PD Testing: A Feasibility Study in Malaria, Vivax | — | 2023-08-28 |
| Completed | Piperaquine Granule Formulation Relative Bioavailability and Food Effect Study in Healthy Volunteers. Malaria | Phase 1 | 2023-08-14 |
| Completed | Phase 1b MMV367 PK/PD and Safety in Healthy Adult Volunteers Experimentally Infected With Blood Stage P. Falci Infections, Vector Borne Diseases, Systemic Inflammatory Response Syndrome | Phase 1 | 2023-08-01 |
| Completed | First-in-Human Study to Assess the Safety, Tolerability and Pharmacokinetics of MMV367 Malaria,Falciparum | Phase 1 | 2022-07-29 |
| Completed | Pyronaridine in Healthy Adult Participants Infected With Blood Stage Malaria Malaria,Falciparum, Malaria, Malaria Recrudescence | Phase 1 | 2022-04-04 |
| Completed | MMV533 Plasmodium Falciparum Volunteer Infection Study Malaria | Phase 1 | 2022-03-30 |
| Completed | A Healthy Volunteer Safety Study of Pyronaridine Tetraphosphate Taken in Combination With Piperaquine Tetrapho Healthy | Phase 1 | 2022-02-14 |
| Completed | Atoguanil BA Study Bioavailability | Phase 1 | 2021-11-17 |
| Completed | Assess Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Profile of Ruxolitinib With Artemether-lumefa Malaria | Phase 1 | 2020-09-10 |
| Completed | A Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetic Profile of a Single Doses of MMV533. Malaria | Phase 1 | 2020-08-12 |
| Completed | Study in Blood Stage Malaria Infection After DVI of Cryopreserved P. Falciparum (NF54 Strain) Sporozoites Malaria,Falciparum, Parasitemia, Protozoan Infections | Phase 1 | 2020-02-19 |
| Completed | Determine the Tolerability and Safety of Atovaquone-proguanil (ATV-PG) Co-administered With Amodiaquine (AQ) Malaria | Phase 1 | 2019-04-04 |
| Completed | Safety, Tolerability and Chemoprotective Activity of P218 in PfSPZ Challenge Model Malaria | Phase 1 | 2018-11-16 |
| Completed | Malaria: Relative Bioavailability and Food Effect of DSM265 Healthy Volunteers | Phase 1 | 2018-10-03 |
| Completed | Safety, Tolerability and Antimalarial Activity of Single Doses of OZ439 and PQP Malaria | Phase 1 | 2018-04-23 |
| Withdrawn | Chemoprotective Activity of MMV390048 in PfSPZ Challenge Model Malaria,Falciparum | Phase 1 | 2018-01-01 |
| Terminated | MMV390048 POC in Patients With P. Vivax and P. Falciparum Malaria Malaria | Phase 2 | 2017-10-20 |
| Completed | Absolute BA and OZ439 PK Effect of Different OZ439 Dose Volumes and Cobicistat Co-administration Study Malaria | Phase 1 | 2017-02-28 |
| Completed | SJ733 Induced Blood Stage Malaria Challenge Study Plasmodium Falciparum Malaria | Phase 1 | 2016-09-13 |
| Completed | A FIH Study to Investigate the Safety, Tolerability and PK of P218 Malaria | Phase 1 | 2016-08-24 |
| Terminated | Bioavailability and Effect of Food on DSM265 Granules in Healthy Adult Subjects Healthy Volunteers, Bioavailability | Phase 1 | 2016-05-01 |
| Completed | MMV390048 and Its Antimalarial Activity Against Plasmodium Falciparum in Healthy Adult Subjects, Part B Malaria | Phase 1 / Phase 2 | 2016-05-01 |
| Completed | Safety, Tolerability and Pharmacokinetic Profile of Ascending Oral Doses of MMV390048, Part A Malaria | Phase 1 | 2016-05-01 |
| Completed | DSM265 Prophylaxis of Plasmodium Falciparum Malaria Healthy | Phase 1 | 2016-03-01 |
| Completed | DSM265 Phase IIa Investigation Treating Plasmodium Falciparum or Vivax Plasmodium Falciparum Malaria, Plasmodium Vivax Malaria | Phase 2 | 2016-01-01 |
| Completed | DSM265 Chemoprophylaxis of Plasmodium Falciparum Malaria Plasmodium Falciparum, Malaria | Phase 1 | 2015-10-01 |
| Terminated | A Study to Characterise the Antimalarial and Transmission Blocking Activity of a Single Dose of DSM265 or OZ43 Malaria | Phase 1 / Phase 2 | 2015-10-01 |
| Completed | A Study to Evaluate the Pharmacokinetics of Oral Formulations of MMV390048 Administered Fasted to Healthy Volu Malaria | Phase 1 | 2015-09-17 |
| Completed | Effectiveness of OZ439 as a Gametocytocidal and Transmission Blocking Agent Malaria | Phase 1 / Phase 2 | 2015-04-01 |
| Completed | Experimental Falciparum Transmission to Anopheles Malaria | Phase 1 | 2015-04-01 |
| Completed | Bioavailability Study of Oral OZ439 Prototype Granule Formulations Administered With Piperaquine Phosphate (PQ Malaria | Phase 1 | 2015-04-01 |
| Completed | A Phase Ib Induced Malaria Infection Study With the Combination of OZ439 and DSM265 Malaria | Phase 1 / Phase 2 | 2015-02-01 |
| Terminated | MMV390048 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy Participants Malaria, Falciparum | Phase 1 | 2014-10-01 |
| Completed | Phase II Efficacy Study of Artefenomel & Piperaquine in Adults & Children With P. Falciparum Malaria. Uncomplicated Plasmodium Falciparum Malaria | Phase 2 / Phase 3 | 2014-07-01 |
| Completed | Bioavailability Study of Oral OZ439 Prototype Formulations Administered With Piperaquine Phosphate (PQP) Malaria | Phase 1 | 2014-07-01 |
| Completed | Phase I Study of Ascending Doses of MMV390048 in Healthy Adult Volunteers Malaria | Phase 1 | 2014-05-01 |
| Completed | Open Label Pharmacokinetic Study of OZ439 and Piperaquine on Administration of OZ439+TPGS Granules for Oral Su Malaria | Phase 1 | 2013-10-01 |
| Completed | Relative Bioavailability of Pyronaridine-artesunate in Tablet and Granule Formulations in Healthy Volunteers Malaria | Phase 1 | 2013-05-01 |
| Completed | Healthy Volunteer Study of the Pharmacokinetics of Oral Piperaquine With OZ439 + TPGS Formulation in the Faste Malaria | Phase 1 | 2013-04-01 |
| Completed | OZ439 PhIIa Study in Plasmodium Falciparum: Extended Observation Malaria | Phase 2 | 2013-03-01 |
| Completed | A Comparison of the Bioavailability of OZ439 When Delivered Directly to the Small Intestine, or Via the Oral R Healthy Volunteers | Phase 1 | 2012-11-01 |
| Completed | A Dose-escalation Study to Investigate Safety and Toleration of OZ439 Malaria | Phase 1 | 2012-11-01 |
| Completed | Effectiveness of OZ439 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy Volunteers Malaria | Phase 1 | 2012-09-01 |
| Completed | Safety Tolerability & Pharmacokinetics of Co-administered Single Doses of OZ439 & Piperaquine to Healthy Subje Healthy | Phase 1 | 2012-09-01 |
| Terminated | Safety, Tolerability & Pharmacokinetics (PK) of Co-administered Single Doses of OZ439 and Mefloquine (MQ) in H Malaria | Phase 1 | 2012-08-01 |
| Completed | Study To Investigate The Relative Bioavailability of OZ439 Formulations In Healthy Volunteers Healthy Volunteers | Phase 1 | 2012-04-01 |
| Completed | Drug Interaction Study of Pyronaridine-artesunate & Metoprolol, & Redosing Study of Pyronaridine-artesunate Malaria | Phase 1 | 2012-01-01 |
| Completed | Human Mass Balance Study of Pyronaridine Malaria | Phase 1 | 2011-06-01 |
| Completed | Efficacy, Tolerability, PK of OZ439 in Adults With Acute, Uncomplicated P.Falciparum or Vivax Malaria Mono-inf Malaria, Falciparum, Malaria, Vivax | Phase 2 | 2010-10-01 |
| Completed | Pyronaridine Artesunate-Ritonavir Drug-drug Interaction Study Malaria | Phase 1 | 2010-07-01 |
| Completed | A Pilot Study to Test Activity of Antimalarial Drugs Against an Induced Malaria Infection in Healthy Volunteer Healthy, Non-smokers | Phase 1 / Phase 2 | 2010-01-01 |
| Completed | A Study to Investigate the Safety, Tolerability and Pharmacokinetics of OZ439 in Healthy Male and Female Subje Malaria Falciparum, Malaria Vivax, Healthy Volunteers | Phase 1 | 2009-04-01 |
| Completed | Pyronaridine Artesunate 3:1 Granule Formulation vs. Coartem© Crushed Tablets in P. Falciparum Malaria Pediatri Malaria | Phase 3 | 2007-10-01 |
| Terminated | Safety and Efficacy of Pyronaridine Artesunate Vs Chloroquine in Children and Adult Patients With Acute Vivax Malaria | Phase 3 | 2007-09-06 |
| Completed | Phase II Artesunate Study in Severe Malaria Malaria | Phase 2 | 2007-09-01 |
| Completed | Bioequivalence Trial of Pyronaridine Artesunate To-be-marketed Tablet to the Clinical Trial Reference Tablet Malaria | Phase 1 | 2007-09-01 |
| Completed | Pyronaridine Artesunate (3:1) in Children and Adults With Acute Plasmodium Vivax Malaria Malaria | Phase 3 | 2007-03-01 |
| Completed | Pyronaridine Artesunate (3:1) Versus Coartem® in P Falciparum Malaria Patients Malaria | Phase 3 | 2007-01-01 |
| Completed | Pyronaridine - Artesunate (3:1) Versus Mefloquine Plus Artesunate in Plasmodium Falciparum Malaria Patients Falciparum Malaria | Phase 3 | 2007-01-01 |
| Completed | Pyronaridine and Artesunate (3:1) in Children With Acute Uncomplicated Plasmodium Falciparum Malaria Uncomplicated Plasmodium Falciparum Malaria | Phase 2 | 2006-06-01 |
| Completed | RBx11160 Phase II Dose Ranging Study RBx/MMV05-06 Plasmodium Falciparum Malaria | Phase 2 | 2006-06-01 |
| Completed | Phase II Dose-ranging Study of Pyronaridine/Artesunate in Adults Patients With Plasmodium Falciparum Malaria Plasmodium Falciparum Malaria | Phase 2 | 2005-07-01 |