Trials / Completed
CompletedNCT01020409
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
INFLACOR (INFLA-mmation A-fter C-ardiac O-pe-R-ation) - Use of Selected Genetic Variants, Cytokines, and Physiologic Parameters in the Prognosis of Postoperative Complications in Patients Undergoing Cardiopulmonary Bypass Cardiac Surgery
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 525 (actual)
- Sponsor
- Medical University of Gdansk · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary bypass.
Detailed description
Identified so far predictors of mortality and/or morbidity in patients who undergo heart surgery with cardiopulmonary bypass (CPB), used in previous risk prediction models (EUROSCORE, CABDEAL, Cleveland), will be compared with new candidate variables: 1. anamnestic: recent tooth extractions, chronic inflammatory diseases, specific drug use; 2. biochemical: C-reacting protein, interleukin-6, tumor necrosing factor alpha; 3. genetical: single nucleotide polymorphisms of 10 genes associated with inflammatory response; and 4. clinical from the 1. postoperative day: systemic inflammatory response syndrome, APACHE-III score; against their predictive capability of selected clinical phenotypes of inflammatory response occuring after surgery, beginning from day 2. after surgery.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | cardiac surgery with CPB use | cardiac surgery with CPB use or ascending aorta surgery performed with use of cardiopulmonary bypass with or without aortic cross clamping. |
Timeline
- Start date
- 2009-10-01
- Primary completion
- 2011-04-01
- Completion
- 2012-11-01
- First posted
- 2009-11-25
- Last updated
- 2016-11-15
Locations
1 site across 1 country: Poland
Source: ClinicalTrials.gov record NCT01020409. Inclusion in this directory is not an endorsement.