NCT07101367

A Comparative Study Between Dexmedetomidine Versus Methylprednisolone on Induced Inflammatory Response in Patients Undergoing On-pump CABG

• Status: Not Yet Recruiting
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 21 Years – 60 Years
• Healthy volunteers: Accepted

Summary

A comparison between precedex versus solumedrol as anti-inflammatory stress response inhibitors in patients undergoing on-pump CABG using different inflammatroy response parameters and the outcome of the drugs on the cognitive and cardiac status post extubation

Conditions

• Coronary Artery Disease
• Systemic Inflammatory Response Syndrome
• Postoperative Complications

Interventions

Type	Name	Description
DRUG	Normal saline	After induction of anesthesia give 10 ml of normal saline then followed by infusion of normal saline till extubation of patient in ICU
DRUG	Dexmedetomidine	After induction of anesthesia give loading dose of precedex 1 mcg/kg diluted in 10 ml normal saline then attach syringe pump of precedex infusion of 0.5mcg/kg/hr till extubation in ICU
DRUG	Methylprednisolone	After induction of anesthesia give solumedrol of a dose 10mg/kg diluted in 10ml of normal saline followed by a normal saline infusion till the extubation of the patient in the ICU

Timeline

• Start date: 2025-09-01
• Primary completion: 2026-08-31
• Completion: 2026-08-31
• First posted: 2025-08-03
• Last updated: 2025-08-06

Locations

1 site across 1 country: Egypt

Regulatory

• FDA-regulated drug study