NCT00519350

Towards a High-fat Feeding Intervention Study: Identification of Markers for Inflammation and Organ Damage

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 24 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Patients undergoing major surgery, trauma or burns are prone to develop an exacerbated inflammatory response, which is potentially lethal to the individual. Recently, the researchers' group showed in a rodent model of hemorrhagic shock that high-fat feeding administered before shock attenuates inflammation and reduces intestinal and hepatic damage. In the mechanism that underlies this protective effect, the release of cholecystokinin in gut wall and activation of efferent vagus bundles are crucial events. Before investigating the effect of high-fat nutrition in clinical setting, suitable markers of inflammation and organ damage need to be selected. In this study, blood will be collected in patients undergoing different types of operations. Consequently several markers for inflammation and organ damage will be determined. Hence, suitable parameters for a future high-fat intervention study will be selected.

Conditions

• Systemic Inflammatory Response Syndrome
• Sepsis

Interventions

Type	Name	Description
PROCEDURE	Blood collection	In arterial or venous lines already present, small amounts of blood will be collected at certain timepoints following operation

Timeline

• Start date: 2007-08-01
• Primary completion: 2009-06-01
• Completion: 2009-06-01
• First posted: 2007-08-22
• Last updated: 2017-02-24

Locations

1 site across 1 country: Netherlands