NCT00293592

Dexamethasone for Cardiac Surgery Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 4,500 (actual)
• Sponsor: UMC Utrecht · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a multicenter, randomized, double-blind trial, comparing clinical outcomes after the administration of high-dose dexamethasone versus placebo in patients undergoing heart surgery with the use of cardiopulmonary bypass. The primary endpoint is the occurrence of major complications (including all-cause mortality, myocardial infarction, stroke, renal failure, and prolonged mechanical ventilation) in the first 30 days after surgery.

Conditions

• Systemic Inflammatory Response Syndrome
• Cardiac Diseases
• Postoperative Complications

Interventions

Type	Name	Description
DRUG	Dexamethasone	1 mg per kg as a single dose before initiation of cardiopulmonary bypass

Timeline

• Start date: 2006-05-01
• Primary completion: 2011-11-01
• Completion: 2012-12-01
• First posted: 2006-02-17
• Last updated: 2015-04-21

Locations

1 site across 1 country: Netherlands