NCT03283345

Effect of Menstrual Cycle on Traumatic Systemic Response

ASSESSMENT OF SYSTEMIC RESPONSES TO TRAUMA IN DIFFERENT PHASES OF THE MENSTRUAL CYCLE: IN PATIENTS UNDERWENT MODIFIED RADICAL MASTECTOMY A Clinical Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 89 (actual)
• Sponsor: Kocaeli University · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Accepted

Summary

It is aimed to evaluate pathophysiology of systemic responses to trauma via using interleukin (IL) -1 and IL-6 levels and determining timing of surgery through phases of menstrual cycle.

Detailed description

89 female breast cancer patient who underwent modified radical mastectomy included into study. Menstrual history and hormone levels were used to determine menstrual phase: luteal, follicular, and other. IL-1β and IL-6 levels, which are related to severeness of inflammation, were measured one day before and one day after surgery. Those are statistically analysed to show effect of timing of breast surgery on responses to trauma in postmenopausal and premenopausal women during different phases of their menstrual cycles

Conditions

• Systemic Inflammatory Response Syndrome

Interventions

Type	Name	Description
PROCEDURE	modified radical mastectomy	systemic responses to trauma are compared with evaluating inflammatory cytokine levels between premenopausal and postmenopausal patient groups with different estrogen levels who underwent modified radical mastectomy.

Timeline

• Start date: 2008-06-01
• Primary completion: 2018-11-01
• Completion: 2018-11-01
• First posted: 2017-09-14
• Last updated: 2017-09-18