| Not Yet Recruiting | Randomized Trial of Combination Treatment With Sofwave and Sculptra NCT07342452 | Massachusetts General Hospital | Phase 4 |
| Not Yet Recruiting | Objective Evaluation of Intradermal MSC-Derived Exosome Therapy on Facial Skin Quality NCT07466953 | Mert Ersan | Phase 3 |
| Not Yet Recruiting | Preliminary Evaluation of the Safety and Tolerability of SPOT-mRNA01 Subcutaneously Administered in Healthy Su NCT06567119 | SIPO Biotechnology Co. Ltd. | Phase 1 |
| Completed | Multidimensional Correlation Study on Skin Aging in Menopausal Women NCT07390305 | ChinaNorm | — |
| Not Yet Recruiting | Menopausal Impact on Skin Aging Among Egyptian Women NCT07120542 | Sohag University | — |
| Enrolling By Invitation | MENA Consensus on Poly-L-Lactic Acid (PLLA) Biostimulator Use in Aesthetic Dermatology NCT07261748 | Venus Research Center | — |
| Completed | Safety and Efficacy of a Microneedling Device Used in Facial Aesthetics NCT06933225 | Circa Skin Ltd | N/A |
| Active Not Recruiting | Focused Ultrasound Treatment for Facial Skin Laxity NCT07381218 | The Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College | N/A |
| Enrolling By Invitation | Evaluation of the Safety and Efficacy of an Injectable Liposomal Gel NCT06997380 | Biovico Sp. z o.o. | N/A |
| Completed | A Pilot Study to Evaluate the Expanded Reach of Decentralized Digital Skin Health Clinical Studies NCT07193290 | Kenvue Brands LLC | — |
| Not Yet Recruiting | A Clinical Study on Pre-operative Intervention With Products During Aesthetic Medicine NCT06891924 | Botanee Group Co., Ltd. | N/A |
| Completed | Effectiveness of a Bilayering Serum and Cream Containing GABA, DMAE, Cysteamine, and Bakuchiol for Skin Whiten NCT07477288 | Hasanuddin University | Phase 2 |
| Active Not Recruiting | Evaluation of the Skin-Beautifying Effects of Collagen Drinks NCT06900660 | Simply Plus Co., Ltd. | N/A |
| Active Not Recruiting | A Clinical Study to Evaluate the Efficacy of Activated Silk™ 27P-α in Subjects, Aged 35-65 Years of Age, to Im NCT06804772 | Victoria Collotta | N/A |
| Active Not Recruiting | A Clinical Study to Evaluate the Efficacy of Activated Silk™ 27P-α in Subjects, Aged 35-65 Years of Age, to Im NCT06804759 | Victoria Collotta | N/A |
| Active Not Recruiting | Study on Safety and Efficacy of Monopolar Radio Frequency Device for Facial Skin Tightening NCT06816069 | CLASSYS Inc. | N/A |
| Completed | A Study to Evaluate the Effect of a Topical Retinol on Epigenetic Changes and Expression of Certain Genes in t NCT06658847 | Johnson & Johnson Consumer Inc. (J&JCI) | N/A |
| Not Yet Recruiting | Efficacy and Safety of Skincare Serum and Cream for Anti-aging of Facial Skin NCT06638905 | Goldman, Butterwick, Fitzpatrick and Groff | Phase 2 / Phase 3 |
| Completed | Clinical Trial to Evaluate the Efficacy of Skin Products to Improve Skin Quality and Health NCT06853899 | Truology | N/A |
| Recruiting | Biometrical Evaluation of the Efficacy of a Food Supplement Versus Placebo NCT06727292 | Finzelberg GmbH & Co. KG | N/A |
| Completed | The Effects of an LED Face Mask & Neck and Chest Mask On Skin Health NCT07025837 | Freedom Laser, Inc. | N/A |
| Completed | Evaluation of the Anti-aging Efficacy of One Face Care Cosmetic Product NCT06619457 | Amazentis SA | N/A |
| Recruiting | Evaluation of the Safety and Efficacy of Profhilo® Structura NCT06719154 | IBSA Farmaceutici Italia Srl | — |
| Completed | Effects of Microtox on Facial Skin Quality, Fine Wrinkles, and Texture NCT06604832 | Kalpna Kay Durairaj, MD, FACS | Phase 1 |
| Completed | Efficacy Study of Oral Collagen Peptide on Skin Condition Improvement NCT06847035 | Shanghai Meifute Biotechnology Co., Ltd | N/A |
| Completed | Evaluation of Effectiveness and Safety of Stabilized Injectable Hyaluronic Acid (Perleux Body, Produced by Esp NCT06844760 | Espad Pharmed | N/A |
| Withdrawn | An Investigation of a Multi-Function Skincare Product to Improve Aging, Eczema, and Acne Outcomes NCT05873933 | Hemptress | N/A |
| Completed | Effects on Facial Skin Aging After Topical Application of Exosomes With a Microneedling Device NCT07372001 | Instituto de Oftalmología Fundación Conde de Valenciana | Phase 4 |
| Completed | Reduction in Symptoms After Laser Therapy With Acorn aHFS NCT06336135 | Acorn Biolabs Inc. | — |
| Completed | Potential of Gayo Arabica Coffee Skin NCT06940076 | Wahyu Lestari | Phase 2 |
| Unknown | A Clinical Study to Evaluate the Efficacy and Safety of Monopolar Radiofrequency Combined With SkinCeuticals A NCT06228833 | Yes Skin Medical Group | N/A |
| Active Not Recruiting | TCRM for Correction of Cheek Including Fine Lines NCT07145905 | Teoxane SA | N/A |
| Completed | Relationship Between Serum Xanthine Oxidase Levels and Seborrheic Keratosis NCT07095348 | Sri Nauli Dewi Lubis | — |
| Withdrawn | The Role of Red Flavonoid in Photoaging NCT05854628 | Johns Hopkins University | N/A |
| Completed | A Comparative Split-Face Study of the Effects of a Retinol Alternative Cream on Improving Facial Skin Aging NCT06125912 | Dime Beauty Co. | N/A |
| Completed | Facial Contouring With Monopolar RF and Continuous Water Cooling NCT07317089 | Yonsei University | N/A |
| Completed | Efficacy of a Dietary Supplement on Parameters of Skin Aging in Men and Women NCT06083402 | Natals, Inc. dba Ritual | N/A |
| Completed | Evaluation of the Safety and Effectiveness of the Investigational Product in Improvement of the Appearance of NCT05997654 | Silimed Industria de Implantes Ltda | N/A |
| Unknown | A Clinical Study to Evaluate the Efficacy and Satisfaction of Ultrasound Therapy Combined With SkinCeuticals A NCT05748470 | Yes Skin Medical Group | N/A |
| Completed | Multicenter, Prospective Study to Determine the Performance and Safety of the New M-HA30 Architect Device on t NCT07007351 | Laboratoires FILLMED | N/A |
| Completed | Effects of Stabilized Retinaldehyde on Aging Skin: A Split-Face Study NCT07510165 | Medical University of Silesia | N/A |
| Completed | Evaluation of the Safety and Performance Characteristics of Mesofiller Mesotox for the Correction of Wrinkles NCT06477432 | Mesoestetic Pharma Group S.L. | N/A |
| Completed | Evaluation of the Safety and Performance Characteristics of Mesofiller Aox for the Correction of Mild and Mode NCT06486740 | Mesoestetic Pharma Group S.L. | N/A |
| Completed | Cucurbita Pepo Flowers Extract to Promote Skin Health NCT06674005 | Ritamaria Di Lorenzo | N/A |
| Completed | Clinical Study to Evaluate the Anti-aging Efficacy of Dermial® NCT05813054 | Bioiberica | N/A |
| Completed | Microneedle Versus Fractional CO₂ Laser for Skin Aging Treatment With Stem Cell Secretome in Indonesian Adult NCT05508191 | Shannaz Nadia Yusharyahya | N/A |
| Completed | Evaluation of the Anti-aging Efficacy of Four Skin Health Products NCT05473832 | Amazentis SA | N/A |
| Unknown | Comparison of an Office-based Limited Facelift and Hospital-based Full Facelift NCT05419609 | Dufresne, Craig, MD, PC | N/A |
| Completed | Evaluation of the Anti-aging Efficacy of a Novel Skin Health Product NCT05300984 | Amazentis SA | N/A |
| Completed | Efficacy and Performance Evaluation of mGlobal L+AS 20 mg/ml Hyaluronic Acid, for the Correction of Light to M NCT06482723 | Mesoestetic Pharma Group S.L. | N/A |
| Completed | The Efficacy of a Cosmetic Preparation Containing Sheep Colostrum on Mature Skin NCT06305923 | Medical University of Lodz | N/A |
| Completed | Efficacy and Performance Evaluation of mIntense L+AS 25 mg/ml Hyaluronic Acid for the Correction of Moderate t NCT06451822 | Mesoestetic Pharma Group S.L. | N/A |
| Unknown | TEOSYAL RHA® 1 for Neck Lines, Perioral Lines and Smiling Lines NCT05349799 | Teoxane SA | N/A |
| Terminated | Novel Antiaging Regenerative Skin Care Regimen Containing Human Platelet Extract (HPE) NCT05457491 | Mayo Clinic | Phase 1 |
| Unknown | TCA Peel and Photobiomodulation for Hand Rejuvenation NCT04485091 | University of Nove de Julho | Phase 2 |
| Completed | Comparative Study of a 1064-nm Fractional Picosecond Laser Versus IPL in Facial Rejuvenation NCT07122310 | Huashan Hospital | N/A |
| Completed | A Proof of Concept Study to Evaluate the Efficacy and Tolerability of Skinpen on Male and Female Subjects' Dor NCT05030051 | Crown Laboratories, Inc. | N/A |
| Completed | Computer-based Skin Aging Simulation for Skin Cancer Prevention NCT04532437 | University Hospital, Basel, Switzerland | — |
| Unknown | Transplantation of Fibroblast for Correction of Nasolabial Folds NCT03140319 | SCARM Institute, Tabriz, Iran | Phase 1 / Phase 2 |
| Completed | A Randomized, Double-blinded, Placebo Controlled, Monocentric Study to Evaluate the Anti-ageing and Skin Brigh NCT04276753 | Ratan K. Chaudhuri | N/A |
| Completed | Nourishing Hair, Skin & Nails Supplement Study (Derm Aid) NCT04249128 | ProofPilot | Phase 3 |
| Completed | Effect of Oligopin® on Skin Ageing NCT04141059 | Technological Centre of Nutrition and Health, Spain | N/A |
| Active Not Recruiting | Effect of Topical Sulforaphane on Skin Aging and With Ultraviolet and Visible Light Exposure NCT03730649 | Johns Hopkins University | EARLY_Phase 1 |
| Completed | Efficacy of Extract of Trigonella Foenum-graceum as Topical Phytoestrogen in Skin Aging Treatment of Post Meno NCT04123743 | Indonesia University | Phase 1 / Phase 2 |
| Unknown | Efficacy and Safety of Skin Care Product in Aging Facial Skin NCT04015063 | National Taiwan University Hospital | N/A |
| Terminated | Bioclinical Study of Scalp Photoaging of a Population Male Over 65 Years Old. NCT03603587 | Centre Hospitalier Universitaire de Saint Etienne | N/A |
| Completed | Pilot Study to Evaluate the Safety and the Efficacy of the Matrix and Cells Obtained by the AmeaCell® Device a NCT03529292 | Symbioken | N/A |
| Completed | Beauty Image Efficacy Study NCT04733755 | Pharmanex | N/A |
| Completed | Relationship of Skin Related SNP to Topical Skin Care Product NCT03446079 | HelicalCodeMD | N/A |
| Completed | Astaxanthin (2 mg) + Lycopene (1.8 mg) + D-Alpha-Tocopherol (10 IU) For The Treatment Of Skin Aging NCT03460860 | United Laboratories | N/A |
| Completed | Open-label, Prospective, Multicenter Study to Evaluate the Cutera Excel V™ Laser and a Micro-Lens Array Attach NCT03424148 | Cutera Inc. | N/A |
| Completed | Effectiveness and Safety of Collagen Complex COLLOST in Anti-age Therapy NCT03677258 | Nearmedic Plus LLC | N/A |
| Completed | Evaluation of the Efficacy and Tolerance of a Light Therapy Mask on Mild to Moderate Brown Spots and Moderate NCT03312543 | Johnson & Johnson Consumer Inc. (J&JCI) | N/A |
| Completed | Proof of Concept Anti-ageing Clinical Study in Healthy Subjects NCT03180645 | GlaxoSmithKline | N/A |
| Unknown | MĒ Device for At-Home Skin Rejuvenation NCT02902718 | Iluminage Ltd. | N/A |
| Completed | Clinical Evaluation of Day and Night Skin Care Creams Supplemented With MediCell Technology (MCT)'s Compositio NCT02765763 | Advanced Dermatology | Phase 4 |
| Completed | Safety and Efficacy of Botulinum Toxin Type A Topical Gel for Lateral Canthal Lines NCT02580370 | Revance Therapeutics, Inc. | Phase 3 |
| Unknown | Comparison of Escalating Doses of IncobotulinumtoxinA (Xeomin®) in the Treatment of Glabellar Rhytids NCT01583478 | The Maas Clinic | Phase 4 |
| Unknown | Tolerance and Efficacy Evaluation of 3 Face Creams NCT02063971 | Adele Sparavigna | N/A |
| Completed | Poly-L-lactic Acid for Skin Quality NCT02003833 | Sadick Research Group | Phase 4 |
| Completed | Efficacy and Safety of Botulinum Toxin Type A for Moderate to Severe Crow's Feet Lines NCT01940991 | Revance Therapeutics, Inc. | Phase 2 |
| Completed | Study of Skin Parameters in the PROOF Cohort NCT02104960 | Centre Hospitalier Universitaire de Saint Etienne | — |
| Terminated | Open Label Study to Assess Long-term Safety of Repeat Administration of Botulinum Toxin Type A for Moderate to NCT01818076 | Revance Therapeutics, Inc. | Phase 3 |
| Completed | Thermage CPT for Treatment of Facial and Neck Laxity NCT01783496 | Valeant Pharmaceuticals | N/A |
| Completed | Efficacy and Safety Study of Botulinum Toxin Type A for Moderate to Severe Crow's Feet Lines NCT01776606 | Revance Therapeutics, Inc. | Phase 3 |
| Completed | A Study to Evaluate the Safety and Effectiveness of the Cryo-Touch II Device for the Treatment of Forehead and NCT01447342 | Pacira Pharmaceuticals, Inc | Phase 2 / Phase 3 |
| Completed | To Evaluate the Safety and Efficacy of Botulax® Are Not Inferior to Those of Botox® in the Treatment of Glabel NCT01791920 | Hugel | Phase 3 |
| Unknown | Facial Cosmetic Acupuncture on Skin Rejuvenation NCT01486303 | Kyunghee University | N/A |
| Completed | Cryo-Touch III Refinement Study Investigational Plan NCT01379365 | Pacira Pharmaceuticals, Inc | Phase 2 / Phase 3 |
| Completed | Efficacy and Safety Study of Botulinum Toxin Type A to Treat Glabellar Lines NCT01237977 | Medy-Tox | Phase 3 |
| Completed | Comparison of the Effects of Carboxytherapy and Radiofrequency on Skin Rejuvenation NCT01981980 | Adriana Clemente Mendonça | N/A |
| Completed | Clinical Trial to Assess Efficacy, Safety and Tolerability of Botulinum Toxin A (Xeomin®) in Treatment of Expr NCT00986570 | Biolab Sanus Farmaceutica | Phase 3 |
| Completed | Comparison of Redermic, Rejuva-A and Combination of Both Redermic and Rejuva-A in Subjects With Signs of Aging NCT00974480 | Cosmetique Active International | N/A |
| Completed | Patient Satisfaction With Treatment of BOTOX® Cosmetic for the Temporary Correction of Moderate to Severe Glab NCT00856414 | Allergan | Phase 4 |
| Completed | Evaluation of Safety and Efficacy of Using EndyMed Pro Skin Treatment System for Skin Wrinkle Treatment on Bod NCT01029301 | Endymion Medical Ltd | N/A |
| Unknown | Effects of Oral and Topical Sea Buckthorn Oil Treatments on Skin Aging NCT00767156 | Institute of Skin and Product Evaluation, Italy | N/A |
| Completed | Identification of Gene Biomarkers in Aging Skin NCT00884936 | Interleukin Genetics, Inc. | — |
| Completed | Comparison of Outcome Parameters in Laser Rhytide Treatment NCT00994474 | Laserklinik Karlsruhe | Phase 4 |
| Completed | Evaluation of Safety and Efficacy of Using Imagine™ Computerized Radiofrequency System for Skin Tightening NCT00945685 | Endymion Medical Ltd | N/A |
| Completed | Skin Safety Profile of Different Exposure to the Light Emitting Diode (LED) in Healthy Subjects NCT00818311 | L'Oreal | N/A |
| Completed | Trial of Methyl Aminolevulinate Plus Aktilite in Facial Photodamage NCT00629317 | Universidad de Antioquia | Phase 3 |
| Completed | Evaluation of the PlasmaJet Neutral Argon Plasma System to Treat Skin Ageing NCT00761878 | Plasma Surgical Inc | N/A |
| Unknown | Safety and Efficacy Evaluation of Erbium Treatment NCT00766376 | Palomar Medical Technologies, Inc. | N/A |
| Terminated | An Evaluation of Kinerase Pro+Therapy Regimen Vs. Kinerase Vs. Control for the Treatment of Skin Aging NCT00492479 | Innovative Medical | Phase 4 |
| Unknown | Autologous Fibroblast Grafts in Facial Skin Regeneration NCT01490554 | Federal University of São Paulo | N/A |
| Completed | Canadian Aesthetic Experience With Sculptra Therapy NCT00447551 | Bausch Health Americas, Inc. | Phase 4 |
| Completed | Effect of Revival Soy on Weight Loss and Skin, Hair, and Nails in Premenopausal Women NCT00352157 | Physicians Pharmaceuticals, Inc. | Phase 4 |
| Completed | Effect of DHEA on Skin Aging in Postmenopausal Women NCT00248989 | CHU de Quebec-Universite Laval | Phase 3 |
| Completed | Topical Vitamin A Versus Vehicle Cream in the Treatment of Aged Skin NCT00272610 | University of Michigan | Phase 2 |
| Unknown | Evaluation of Excessive UV Irradiation on Skin Aging by Multiphoton Laser Imaging and Biophysical Methods NCT00372047 | University of Jena | — |
| Completed | Light Emitting Diode (LED) for the Treatment of Wrinkles NCT00818246 | RoseLab Skin Optics Laboratory | Phase 2 / Phase 3 |