NCT03730649

Effect of Topical Sulforaphane on Skin Aging and With Ultraviolet and Visible Light Exposure

• Status: Active Not Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The study is to compare the expression of both keratin 16 and 17 before and after application of sulforaphane on both photoprotected and photoexposed area, and to determine whether these findings alter skin aging as well as skin response to ultraviolet (UV) and visible light exposure.

Detailed description

The study is to compare the expression of both keratin 16 and 17 before and after application of sulforaphane on both photoprotected and photoexposed area, and to determine whether these findings alter skin aging as well as skin response to ultraviolet (UV) and visible light exposure. Each study participant will have up to eight study visits. Topical sulforaphane will be applied for up to 6 months. Photography, clinical assessment, UV light irradiation, Visible light treatment, Skin biopsies, non invasive elasticity measurements such as cutometer and ballistometer, and others will be involved in this study.

Conditions

• Skin Aging

Interventions

Type	Name	Description
DRUG	Sulforaphane (broccoli sprout extract)	Participants will topically apply Sulforaphane for a period of time
RADIATION	UV or visible light	Participants will have 2 test areas irradiated with up to 5 UV or visible light treatments

Timeline

• Start date: 2019-10-09
• Primary completion: 2025-03-01
• Completion: 2026-10-01
• First posted: 2018-11-05
• Last updated: 2025-09-26

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study