NCT07372001

Effects on Facial Skin Aging After Topical Application of Exosomes With a Microneedling Device

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Instituto de Oftalmología Fundación Conde de Valenciana · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

In this study, we evaluated the extent of reversal of facial dermal aging signs using topical lyophilized exosomes with a microneedling device

Detailed description

This clinical, experimental, prospective, and comparative investigation was conducted in a before-and-after format. The exosomes were applied to the facial area by dripping onto the skin and using a microneedling device to enhance dermal penetration. Three sessions, each four weeks apart, were performed for each subject. During each session, documentation was performed using photographs and the SAASQ and FaceQ visual scales for objective and subjective evaluations, respectively. ANOVA test for repeated measures was used for the statistical analysis. SPSS version 31.0 was used for the analysis. All measured variables, both objective and subjective, were favorable for the use of exosomes as a treatment for early signs of aging. This pilot study provides preliminary results showing an excellent cosmetic response to exosome treatment using microneedling, with good user satisfaction and tolerable and harmless adverse effects.

Conditions

• Skin Aging

Interventions

Type	Name	Description
BIOLOGICAL	Topical lyophilized exosomes application	The exosomes were applied to the facial area by dripping onto the skin and using a microneedling device to enhance dermal penetration. Three sessions, each four weeks apart, were performed for each subject

Timeline

• Start date: 2024-07-01
• Primary completion: 2024-12-01
• Completion: 2025-03-01
• First posted: 2026-01-28
• Last updated: 2026-01-28

Locations

1 site across 1 country: Mexico