NCT04123743

Efficacy of Extract of Trigonella Foenum-graceum as Topical Phytoestrogen in Skin Aging Treatment of Post Menopausal Women

Efficacy of Extract of Trigonella Foenum-graceum (Fenugreek) as Topical Phytoestrogen in Skin Aging Treatment of Post Menopausal Women : A Study of COL1A1, COL3A1, Skin Thickness, and Skin Wrinkles

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: Indonesia University · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Accepted

Summary

Skin is subjected to intrinsic aging and extrinsic aging. Intrinsic aging is influenced by genetic and hormonal factors. Estrogen has significant role in modulating skin physiology. In post menopausal women, skin aging is accelerated because of hypoestrogenism. Administration of estrogen can delay the process of skin aging. Phytoestrogens are estrogen-like compounds which can be found naturally in plants. The investigators intend to study the efficacy of Trigonella foenum-graceum extract as topical phytoestrogen in skin aging treatment of post menopausal women.

Detailed description

In this double-blinded unmatched randomized controlled trial, the investigators intend to study the efficacy of Trigonella foenum-graceum extract as topical phytoestrogen in skin aging treatment of post menopausal women. The investigators have gathered 21 participants that will be divided into 2 groups, experimental group and control group. Experimental group will get treatment with topical cream containing Trigonella foenum-graceum extract, while control group will get treatment with placebo cream. The study will be held in esthetic cluster, Kencana Cipto Mangunkusumo Hospital, and radiology cluster, Kencana Cipto Mangunkusumo Hospital from August 2019 until November 2019.

Conditions

• Skin Aging

Interventions

Type	Name	Description
DRUG	Trigonella foenum-graceum extract topical cream	Topical cream containing Trigonella foenum-graceum extract
OTHER	Facial Wash	Wardah brand facial wash
OTHER	Sunscreen Cream	Parasol sunscreen cream SPF 33
OTHER	Placebo	Placebo topical cream

Timeline

• Start date: 2019-08-10
• Primary completion: 2019-11-03
• Completion: 2019-11-10
• First posted: 2019-10-11
• Last updated: 2020-07-29

Locations

1 site across 1 country: Indonesia