NCT07477288

Effectiveness of a Bilayering Serum and Cream Containing GABA, DMAE, Cysteamine, and Bakuchiol for Skin Whitening and Anti-Aging

The Effectiveness of a Whitening and Anti-Aging Bilayering Serum and Cream Containing Gamma-Aminobutyric Acid (GABA) 3%, Dimethylaminoethanol (DMAE) 2%, Cysteamine 2.5%, and Bakuchiol 1%

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: Hasanuddin University · Academic / Other
• Sex: Female
• Age: 30 Years – 50 Years
• Healthy volunteers: Accepted

Summary

This study aims to evaluate the clinical efficacy and safety of a multi-functional bilayering skincare regimen-consisting of a serum and cream-for improving skin brightness and reducing wrinkles. The formulation combines four active ingredients: Gamma-Aminobutyric Acid (GABA) 3%, Dimethylaminoethanol (DMAE) 2%, Cysteamine 2.5%, and Bakuchiol 1%. In an 8-week, double-blind, randomized, placebo-controlled trial involving 44 female subjects with Fitzpatrick skin types III-V, investigators will assess changes in skin brightness (L-value), wrinkle scores, pore counts, and melanin/erythema indices using standardized imaging and measurement tools. The primary goal is to determine if this specific combination therapy significantly enhances skin whitening and anti-aging outcomes compared to a placebo.

Conditions

• Skin Aging

Interventions

Type	Name	Description
DRUG	GABA	Gamma-Aminobutyric Acid (GABA) 3%
OTHER	Placebo	Formulations with identical sensory properties (color, scent, and texture) as the active products but lacking the four active ingredients.
DRUG	DMAE	Dimethylaminoethanol 2%
DRUG	Cysteamine	Cysteamine 2,5%
DRUG	Bakuchiol	Bakuchiol 1%

Timeline

• Start date: 2025-03-12
• Primary completion: 2025-09-26
• Completion: 2025-12-29
• First posted: 2026-03-17
• Last updated: 2026-03-24

Locations

1 site across 1 country: Indonesia