| Not Yet Recruiting | Tezepelumab (Tezspire) Regulatory Postmarketing Surveillance in Korea NCT06998095 | AstraZeneca | — |
| Not Yet Recruiting | A Phase 2 Dose Ranging Clinical Study to Evaluate the Efficacy and Safety of Frevecitinib (KN-002) in Patients NCT07532265 | Kinaset Therapeutics Inc | Phase 2 |
| Not Yet Recruiting | Tezepelumab in the Treatment of Emergency Room Asthma in Adults (TERAA) NCT06705764 | University of Alberta | Phase 4 |
| Recruiting | Phase 3b Study in Patients With Severe Asthma Treated With Tezepelumab NCT07363642 | AstraZeneca | Phase 3 |
| Recruiting | A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (S NCT07359846 | Generate Biomedicines | Phase 3 |
| Recruiting | Remission in Adults With Severe Asthma in Thailand NCT07328035 | Thammasat University | — |
| Recruiting | A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (S NCT07276724 | Generate Biomedicines | Phase 3 |
| Recruiting | Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma NCT07139899 | Bastiaan Driehuys | — |
| Enrolling By Invitation | Beyond EOsinophils: proteoMICS to Identify Potential Biomarker of Organ Damage and Response to MEPOLIZUMAB in NCT07343661 | Azienda Ospedaliero Universitaria di Cagliari | Phase 4 |
| Recruiting | Real-World Effectiveness of Benralizumab in Allergic Bronchopulmonary Aspergillosis NCT07530770 | Qianfoshan Hospital | — |
| Not Yet Recruiting | Potency of HDM Sublingual AIT Tablets in Assuring the Persistency of Asthma Control in HDM Allergic Patients W NCT07013123 | University Hospital, Montpellier | Phase 3 |
| Recruiting | Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Severe Asthma NCT06985225 | University of Kansas Medical Center | — |
| Active Not Recruiting | A Long-Term Safety and Efficacy Study of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALOUR) NCT06966479 | Upstream Bio Inc. | Phase 2 |
| Not Yet Recruiting | Withdrawal of Dupilumab in Severe Asthma NCT06818019 | University Hospital, Toulouse | Phase 4 |
| Completed | Characterization and Clinical Outcomes of Severe Asthma Patients in Israel Treated With Benralizumab (SAIL-B) NCT07218172 | AstraZeneca | — |
| Recruiting | Experience of Biologic Treatments for Severe Asthma: a Survey NCT06903780 | Royal Devon and Exeter NHS Foundation Trust | — |
| Not Yet Recruiting | The Inflammatory Profile of Exacerbations in Patients With Severe Asthma Receiving Tezepelumab: The TezEx Stud NCT06666504 | Guy's and St Thomas' NHS Foundation Trust | — |
| Recruiting | Exploring the Lived Experience of Young Adults With Severe Asthma NCT06681545 | Manchester University NHS Foundation Trust | — |
| Completed | Digital Self-Monitoring in Severe Asthma NCT07393984 | University of Medicine and Pharmacy "Victor Babes" Timisoara | N/A |
| Active Not Recruiting | Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clini NCT06473779 | AstraZeneca | Phase 3 |
| Active Not Recruiting | Real-world Study Assessing Efficacy of TezepeLumaB in Patients With Severe Asthma Regardless of Phenotype in R NCT06566885 | AstraZeneca | — |
| Completed | Observational Retrospective Study To Characterize and Assess Clinical Outcomes of Patients Receiving Tezepelum NCT06487065 | AstraZeneca | — |
| Recruiting | Clinical and demOgRaphic Features of Patients With Uncontrolled Severe Asthma in Russia (CORSAR) NCT06472310 | AstraZeneca | — |
| Completed | Patient Characteristics, Treatment Patterns and Outcomes of Patients With Severe Asthma Treated With Tezepelum NCT06455462 | AstraZeneca | — |
| Recruiting | Bronchial Thermoplasty for Adults With Severe Asthma in the Biologic Era NCT07292805 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Completed | PROPE Severe Asthma Study in Egypt NCT06283290 | AstraZeneca | — |
| Enrolling By Invitation | Impact of Respiratory Allergy on Response to Initiation of Biotherapy in Severe Asthma in Adult Severe Asthmat NCT06916104 | Poitiers University Hospital | — |
| Completed | A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Adult Participants With Severe Asthma NCT06196879 | Upstream Bio Inc. | Phase 2 |
| Enrolling By Invitation | K-HEALTH in AIR - Barcelona Pilot - Cohort NCT06421402 | Institut d'Investigacions Biomèdiques August Pi i Sunyer | — |
| Unknown | The BASA Study: Breath Analysis for Severe Asthma Patients NCT05946421 | Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo | — |
| Active Not Recruiting | Using NLP and Neural Networks to Autonomously Identify Severe Asthma and Determine Study Eligibility in a Larg NCT06389058 | San Diego State University | — |
| Not Yet Recruiting | Severe Eosinophilic Asthma Phenotypes During Childhood Have Various Origins NCT05762627 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Patient-Reported OUTcomes of Benralizumab in Real-World Use in Severe EosiNophilic Asthma Patients NCT05603845 | AstraZeneca | — |
| Completed | Modeling Bronchial Epithelium in Severe Asthma With Human Induced Pluripotent Stem Cells (iPSC) NCT05616338 | University Hospital, Montpellier | N/A |
| Completed | Evaluate the Efficacy and Safety of TQC2731 Injection in Patients With Severe Asthma. NCT05472324 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Phase 2 |
| Completed | Evaluate the Pharmacokinetics of BAT2606 Injection in Healthy Chinese Male Subjects NCT05576454 | Bio-Thera Solutions | Phase 1 |
| Recruiting | 3TR Asthma Biologics Cohort (ABC) Study NCT06126692 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Recruiting | Predictive Signature of Benralizumab Response NCT04565483 | Nantes University Hospital | Phase 4 |
| Recruiting | Evaluate the Efficacy and Safety of FB704A in Adult With Severe Asthma NCT05018299 | Oneness Biotech Co., Ltd. | Phase 2 |
| Unknown | Severe Asthma Exacerbations and Mepolizumab Treatment NCT04914078 | Università degli Studi di Ferrara | — |
| Completed | Study in Portuguese Hospitals to Describe Patient Characteristics, Treatment Patterns and Outcomes NCT07159295 | AstraZeneca | — |
| Completed | Adapting Body Reprogramming for Severe Asthma: a Feasibility Study NCT04980755 | Royal Devon and Exeter NHS Foundation Trust | N/A |
| Unknown | Follow-up of Children With Severe Asthma at Adult Age NCT05032209 | Assistance Publique - Hôpitaux de Paris | — |
| Unknown | Defining the Severe Paediatric Asthma Endotype NCT04680117 | Assistance Publique - Hôpitaux de Paris | N/A |
| Recruiting | Phenotyping Asthma for Bronchial Thermoplasty NCT03435237 | Massachusetts General Hospital | — |
| Unknown | Portuguese Severe Asthma Registry: Getting Answers for Severe Asthma Patients NCT04714567 | Sociedade Portuguesa de Pneumologia | — |
| Completed | Impulse Oscillometry Measurements in Severe Eosinophilic Asthmatics Before and After Anti-IL-5 Factor Initiati NCT05147155 | University of Thessaly | — |
| Completed | Real Life Experience Survey of Dupilumab in the Netherlands NCT05331755 | Gert-Jan Braunstahl | — |
| Unknown | Flow Cytometry Analysis of Eosinophils in Severe Asthma Patients. NCT05001529 | Scarlata, Simone, M.D. | Phase 4 |
| Completed | Effectiveness of Anti-IL-5/IL5R Inhibitors NCT06239441 | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | — |
| Completed | Observational Retrospective Study on Clinical Outcomes of Patients Receiving Benralizumab in Spain. NCT04648839 | AstraZeneca | — |
| Unknown | Efficacy of Mepolizumab in Severe Asthmatics on a Long Term (MESILICO) NCT04612556 | Aristotle University Of Thessaloniki | — |
| Completed | Clinical Characteristics of Severe Childhood Asthma NCT06024902 | Children's Hospital of Fudan University | — |
| Unknown | Phenotyping Circulating and Lung Resident Eosinophils in Severe Asthma (P-CLESA) NCT04463836 | Imperial College London | — |
| Unknown | National Survey on Care Pathway and Quality of Life in Patients With Severe Asthma According to Their Phenotyp NCT04438408 | University Hospital, Toulouse | — |
| Recruiting | Deployment o the Multidisciplinary Prospective Cohort Imminent NCT04334031 | University Hospital, Lille | N/A |
| Unknown | Precision Medicine Intervention in Severe Asthma (PRISM) Study NCT05164939 | Asan Medical Center | — |
| Completed | ChAracterisation of ItaliaN Severe Uncontrolled Asthmatic patieNts Key Features When Receiving Benralizumab NCT04272463 | AstraZeneca | — |
| Withdrawn | Benralizumab in the Treatment of Patients With Severe Asthma With ABPA NCT04108962 | Baylor Research Institute | Phase 4 |
| Completed | Patient-reported Outcomes in Real-world Use of Benralizumab in Patients With Severe Eosinophilic Asthma in Bel NCT04221802 | AstraZeneca | — |
| Completed | Long-term Safety of Tezepelumab in Japanese Subjects With Inadequately Controlled Severe Asthma NCT04048343 | AstraZeneca | Phase 3 |
| Completed | Prevalence of the Eosinophilic Phenotype Among Severe Asthma Patients NCT03931954 | AstraZeneca | — |
| Recruiting | Swiss Severe Asthma Register NCT03984253 | Prof. Dr. Jörg Leuppi | — |
| Unknown | Study of Magnitude and Prediction of Response to Omalizumab and Mepolizumab in Adult Severe Asthma. NCT03476109 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | Phase 4 |
| Completed | National Validation and Sensitivity to Change of the SAQ NCT04031261 | University Hospital Plymouth NHS Trust | — |
| Completed | BRazilian Asthmatics Patients EOSinophilic Profile (BRAEOS) NCT03925415 | AstraZeneca | — |
| Recruiting | International Severe Asthma Registry: Canadian Cohort NCT04045587 | University of British Columbia | — |
| Completed | Dupilumab for Severe Asthma in a Real Life Setting NCT04022447 | Assistance Publique - Hôpitaux de Paris | — |
| Unknown | Clinical, Inflammatory and Functional Evaluation of a Population of Severe and Obese Asthmatics: Follow up NCT03532685 | University of Sao Paulo General Hospital | N/A |
| Completed | Characterisation of Patients With Severe Asthma in Primary and Secondary Care Settings in Europe Reported to b NCT03629782 | AstraZeneca | — |
| Unknown | Russian Severe Asthma Registry NCT03608566 | Interregional Public Organization, Russian Respiratory Society | — |
| Completed | Assessment of Treatment Patterns of Severe Asthmatic Patients Across the Gulf Region - SevEos Study NCT03387722 | AstraZeneca | — |
| Unknown | Predictive Value of Spirometric PIF to Produce PIF Rate Needed for the Use of Current DPI's. NCT03377920 | Universitair Ziekenhuis Brussel | N/A |
| Completed | Reslizumab in Patients With Severe Asthma Who Failed to Respond to Omalizumab NCT03074942 | Sociedad Española de Neumología y Cirugía Torácica | Phase 2 |
| Recruiting | Severe Asthma Network Italy NCT06625216 | Società Italiana di Allergologia, Asma e Immunologia Clinica | — |
| Withdrawn | Type 2 Innate Lymphoid Cells in Severe Pediatric Asthma NCT03784781 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | African Severe Asthma Program: A Research Network for Characterisation of Severe Asthma in Africans (ASAP) NCT03065920 | Makerere University | — |
| Unknown | Unraveling Targets of Therapy in Bronchial Thermoplasty in Severe Asthma (TASMA) Extension Study NCT02975284 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Unknown | "SEVERE ASTHMA" in the COMMUNITY NCT01961258 | Meir Medical Center | — |
| Active Not Recruiting | Effect of Biologicals on Alternative Functions of Eosinophils in Severe Asthma NCT04520165 | University of Liege | — |
| Withdrawn | Trial of Simvastatin for the Treatment of Severe Asthma NCT02433535 | University of California, Davis | Phase 2 |
| Active Not Recruiting | Cohort Analysis of Clinical and Biological Severe Childhood Asthma NCT02114034 | Assistance Publique - Hôpitaux de Paris | — |
| Unknown | Clinico-biological Correlation of Severe Asthma in Children NCT02038374 | Assistance Publique Hopitaux De Marseille | N/A |
| Completed | BIOmarkers in Severe AsthMa Patients on Omalizumab Treatment NCT03361111 | Medical University of Warsaw | — |
| Recruiting | Register Schweres Asthma - German Asthma Net e.V. NCT06035289 | German Asthma Net e.V. | — |
| Completed | Bronchial Thermoplasty in Severe Persistent Asthma NCT01350336 | Boston Scientific Corporation | N/A |
| Completed | Treatment of Outpatients With Severe Asthma and Moderate or Severe Major Depressive Disorder NCT00621946 | University of Texas Southwestern Medical Center | Phase 4 |