Trials / Recruiting
RecruitingNCT07139899
Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma
Downstream Effects of Airway Mucus Plugs on 129Xenon MRI Following Biologic Therapy
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 5 (estimated)
- Sponsor
- Bastiaan Driehuys · Academic / Other
- Sex
- All
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with severe asthma. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in regions of the lungs corresponding to the airways downstream of mucus plugs.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| COMBINATION_PRODUCT | Hyperpolarized Xenon 129 | Pulmonary magnetic resonance imaging using hyperpolarized xenon-129 gas as an inhaled contrast agent |
Timeline
- Start date
- 2025-11-17
- Primary completion
- 2026-11-01
- Completion
- 2027-09-01
- First posted
- 2025-08-24
- Last updated
- 2025-11-20
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT07139899. Inclusion in this directory is not an endorsement.