| Not Yet Recruiting | A Study to Assess How Well and Safely Elafibranor Works in Adult Participants With Primary Sclerosing Cholangi NCT07387549 | Ipsen | Phase 3 |
| Recruiting | A Study of TAK-781 in Healthy Volunteers and in Participants With Non-Cirrhotic Primary Sclerosing Cholangitis NCT07229911 | Takeda | Phase 1 |
| Withdrawn | A Study Evaluating the Safety, Tolerability, and Efficacy of Aramchol Meglumine in Primary Sclerosing Cholangi NCT06095986 | Galmed Pharmaceuticals Ltd | Phase 2 |
| Recruiting | Pharmacologic Approaches to Preventing Primary Sclerosing Cholangitis Recurrence After Liver Transplantation NCT06905054 | Mayo Clinic | Phase 2 |
| Not Yet Recruiting | Study with Norucholic Acid Tablets in Patients with Primary Sclerosing Cholangitis (PSC) NCT06886360 | Dr. Falk Pharma GmbH | Phase 3 |
| Recruiting | LEOPARD Training and Validation Data Collection Study NCT06675604 | Assistance Publique - Hôpitaux de Paris | — |
| Not Yet Recruiting | LEOPARD Prospective Validation Cohort 1 NCT06723275 | Assistance Publique - Hôpitaux de Paris | — |
| Withdrawn | A Multi-center Evaluation of Aldafermin in a Randomized, Double-blind, Placebo-controlled Study in Subjects Wi NCT06654726 | NGM Biopharmaceuticals, Inc | Phase 2 / Phase 3 |
| Recruiting | A Study of SIPLIZUMAB in AILD and LT Patients NCT06455280 | Elizabeth C. Verna | Phase 1 |
| Enrolling By Invitation | TruGraf Liver Gene Expression Serial Test NCT06061341 | Washington University School of Medicine | — |
| Recruiting | Liver-gut Axis Study Through Identification of Liver Disease-specific Microbiome NCT06519162 | Chungnam National University Hospital | — |
| Recruiting | The Effects of Bromelain Supplement in Patients With Ulcerative Colitis NCT06351696 | National Nutrition and Food Technology Institute | N/A |
| Recruiting | FAecal Microbiota Transplantation in primaRy sclerosinG chOlangitis NCT06286709 | University of Birmingham | Phase 2 |
| Recruiting | Evaluation of an Oral Microbiota-based Therapeutic as a Treatment Option for PSC NCT06197308 | University of Minnesota | EARLY_Phase 1 |
| Recruiting | Detoxification of the Liver In PSC (Dolphin) NCT05835505 | Brigham and Women's Hospital | Phase 2 |
| Active Not Recruiting | CS0159 in Chinese Patients With PSC (Primary Sclerosing Cholangitis) NCT05896137 | Cascade Pharmaceuticals, Inc | Phase 2 |
| Recruiting | Vancomycin in Primary Sclerosing Cholangitis in Italy NCT05876182 | University of Milano Bicocca | Phase 2 |
| Recruiting | Statin Therapy in Primary Sclerosing Cholangitis (PSC): a Multi-omics Study NCT05912387 | Stanford University | EARLY_Phase 1 |
| Recruiting | Oral Hymecromone to Treat Adolescents and Adults With Primary Sclerosing Cholangitis. NCT05295680 | Aparna Goel | Phase 2 |
| Recruiting | Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative R NCT04685200 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | — |
| Completed | Safety and Tolerability of A3907 in Primary Sclerosing Cholangitis NCT05642468 | Albireo, an Ipsen Company | Phase 2 |
| Active Not Recruiting | Gluten-free Diet in PSC and IBD NCT06026449 | Institute for Clinical and Experimental Medicine | N/A |
| Active Not Recruiting | A Study to Assess Safety and Effectiveness of Elafibranor in Adult Participants With Primary Sclerosing Cholan NCT05627362 | Ipsen | Phase 2 |
| Recruiting | National Database on Primary Sclerosing Cholangitis (PSC) NCT05618145 | University of Milano Bicocca | — |
| Unknown | Multicenter Observational Study of PSC and IgG4-SC in China NCT05463445 | RenJi Hospital | — |
| Not Yet Recruiting | Clinical Application of Annual Liver Multiscan and MRCP+ in Primary Sclerosing Cholangitis NCT05462093 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Recruiting | A-LiNK: Improving Outcomes in Autoimmune Liver Disease NCT05750498 | Children's Hospital Medical Center, Cincinnati | — |
| Unknown | A Systems Biology Approach for Identification of Host and Microbial Mechanisms and Druggable Targets for the T NCT05376228 | University Hospital Birmingham NHS Foundation Trust | — |
| Recruiting | Primary Sclerosing Cholangitis in Children NCT04181138 | Arbor Research Collaborative for Health | — |
| Completed | Evaluation of the Safety and Efficacy of HK-660S in Patients With Primary Sclerosing Cholangitis NCT05866809 | CuromeBiosciences | Phase 2 |
| Unknown | PSC Clinical Epidemiology in China NCT04981756 | Beijing Friendship Hospital | — |
| Unknown | Efficacy of 24 Month of Bezafibrate in Primary Sclerosing Cholangitis With Persistent Cholestasis Despite Urso NCT04309773 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Recruiting | Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients NCT04753996 | Mayo Clinic | — |
| Withdrawn | A Study of HTD1801 in Adolescents With Primary Sclerosing Cholangitis (PSC) NCT03678480 | HighTide Biopharma Pty Ltd | Phase 2 |
| Unknown | Predictive Models of Hepatic Decompensation and Survival Outcomes in Pediatric Patients With Cirrhosis NCT05181332 | West China Hospital | — |
| Withdrawn | Quantitative Magnetic Resonance Imaging in Biliary Disease: Health Economics Study NCT04015310 | Perspectum | — |
| Active Not Recruiting | A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Ca NCT04663308 | Mirum Pharmaceuticals, Inc. | Phase 2 |
| Unknown | CM-101 in PSC Patients -The SPRING Study NCT04595825 | ChemomAb Ltd. | Phase 2 |
| Active Not Recruiting | Effect of Simvastatin on the Prognosis of Primary Primary Sclerosing Cholangitis (PSC) NCT04133792 | Annika Bergquist | Phase 3 |
| Completed | A Pilot Study Examining Diet in Primary Sclerosing Cholangitis NCT04678219 | Brigham and Women's Hospital | N/A |
| Completed | Phase 2a Evaluation of Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Patients With Primary Sclero NCT04480840 | Pliant Therapeutics, Inc. | Phase 2 |
| Completed | Vancomycin for Primary Sclerosing Cholangitis NCT03710122 | Elizabeth Carey | Phase 2 / Phase 3 |
| Terminated | A Study to Evaluate the Safety, and Tolerability, and Efficacy of Seladelpar in Patients With PSC NCT04024813 | Gilead Sciences | Phase 2 |
| Terminated | Safety and Tolerability of Cilofexor in Participants With Primary Sclerosing Cholangitis (PSC) and Compensated NCT04060147 | Gilead Sciences | Phase 1 |
| Completed | Vidofludimus Calcium for Primary Sclerosing Cholangitis NCT03722576 | Elizabeth Carey | Phase 2 |
| Unknown | Volumetric Laser Endomicroscopy's (VLE) Diagnostic Accuracy Validation Study: Impact on Clinical Management St NCT03951324 | Innovative Digestive Health Education and Research Inc | — |
| Terminated | Study of Cilofexor in Adults With Primary Sclerosing Cholangitis NCT03890120 | Gilead Sciences | Phase 3 |
| Completed | Repeatability and Reproducibility of Quantitative MRCP NCT03809559 | Perspectum | — |
| Completed | Sulfasalazine for the Treatment of Primary Sclerosing Cholangitis NCT03561584 | Brigham and Women's Hospital | Phase 2 |
| Active Not Recruiting | norUrsodeoxycholic Acid vs Placebo in PSC NCT03872921 | Dr. Falk Pharma GmbH | Phase 3 |
| Terminated | A Research Study to Evaluate Safety and Efficacy of DUR-928 in Subjects With Primary Sclerosing Cholangitis (P NCT03394781 | Durect | Phase 2 |
| Completed | Detection of Integrin avb6 in IPF, PSC, and COVID19 Using PET/CT NCT03183570 | Stanford University | EARLY_Phase 1 |
| Withdrawn | A Study Of Ursolic Acid For Primary Sclerosing Cholangitis NCT03216876 | University of California, Davis | Phase 1 |
| Completed | A Study Evaluating the Safety and Efficacy of Curcumin in Patients With Primary Sclerosing Cholangitis (PSC) NCT02978339 | John E. Eaton | Phase 1 / Phase 2 |
| Completed | Repeatability and Reproducibility of Multiparametric MRI NCT03743272 | Perspectum | — |
| Completed | A Study of HTD1801 in Healthy Subjects NCT03099603 | HighTide Biopharma Pty Ltd | Phase 1 |
| Recruiting | MRI Biomarkers in as Predictor of Clinical Endpoints in Pediatric Autoimmune Liver Disease NCT03178630 | Children's Hospital Medical Center, Cincinnati | — |
| Unknown | Paternally Inherited Phenotypes in Cholestasis NCT03337074 | Guy's and St Thomas' NHS Foundation Trust | — |
| Withdrawn | Efficacy and Safety of Vedolizumab Intravenous (IV) in the Treatment of Primary Sclerosing Cholangitis in Subj NCT03035058 | Takeda | Phase 3 |
| Recruiting | MRI Based Biomarkers in Pediatric Autoimmune Liver Disease NCT03175471 | Children's Hospital Medical Center, Cincinnati | — |
| Recruiting | Biobank for Cholestatic Liver Diseases. NCT03445585 | Mayo Clinic | — |
| Unknown | Umbilical Cord Mesenchymal Stem Cells in Primary Sclerosing Cholangitis NCT03516006 | Fuzhou General Hospital | Phase 1 / Phase 2 |
| Withdrawn | Vancomycin Treatment in Recurrent PSC in Liver Transplant Patients NCT03046901 | Ochsner Health System | N/A |
| Completed | Study to Evaluate the Safety, Tolerability, and Efficacy of Cilofexor in Adults With Primary Sclerosing Cholan NCT02943460 | Gilead Sciences | Phase 2 |
| Completed | Quality of Life in Patients With Primary Sclerosing Cholangitis NCT02712736 | Duke University | N/A |
| Completed | PERSEUS: Preliminary Efficacy and Safety of Cenicriviroc in Adult Participants With Primary Sclerosing Cholang NCT02653625 | Tobira Therapeutics, Inc. | Phase 2 |
| Completed | A Study of NGM282 in Patients With Primary Sclerosing Cholangitis NCT02704364 | NGM Biopharmaceuticals, Inc | Phase 2 |
| Unknown | The Effect of Bezafibrate on Cholestatic Itch NCT02701166 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Phase 3 |
| Completed | "Overlap Syndrome and PSC: Evaluating Role of Gut Microflora and Its Identification With Antibiotics in Childr NCT03069976 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | N/A |
| Completed | A Trial of BTT1023 in Patients With Primary Sclerosing Cholangitis NCT02239211 | University of Birmingham | Phase 2 |
| Unknown | Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients NCT02605213 | Tehran University of Medical Sciences | Phase 4 |
| Completed | A Pilot Study to Characterize Bile Acid Metabolism and Dysbiosis in Primary Sclerosing Cholangitis NCT02464020 | University of Minnesota | Phase 1 |
| Active Not Recruiting | Disease Status in Primary Sclerosing Cholangitis by Elastography NCT02446665 | University Health Network, Toronto | N/A |
| Completed | Development of a Patient-Reported Outcome Measure to Assess Symptoms in Patients With Primary Sclerosing Chola NCT02247934 | Gilead Sciences | — |
| Completed | Biliary Excretion of Conjugated Bile Acids in Humans Measured by 11C-cholylsarcosine PET/CT NCT01879735 | University of Aarhus | Phase 1 |
| Completed | NKT Role in the Regulation of the Inflammatory Bowel Disease NCT02884557 | University Hospital, Lille | N/A |
| Completed | Registry Trial to Determine pCLE Image Interpretation Criteria and Preliminary Accuracy for PSC Biliary Strict NCT02736708 | University of Colorado, Denver | — |
| Completed | Norursodeoxycholic Acid in the Treatment of Primary Sclerosing Cholangitis NCT01755507 | Dr. Falk Pharma GmbH | Phase 2 |
| Unknown | Mitomycin C Therapy for Patients With Primary Sclerosing Cholangitis NCT01688024 | Li, Zhiping, M.D. | Phase 2 |
| Unknown | Telomere Length and Other Parameters of Telomere Dysfunction in PSC and Colitis NCT02247622 | Meir Medical Center | — |
| Completed | Primary Sclerosing Cholangitis With Oral Vancomycin by the Study of Its Antimicrobial and Immunomodulating Eff NCT01802073 | Stanford University | Phase 3 |
| Unknown | Liver Transplantation for Hilar Cholangiocarcinoma in Association With Neoadjuvant Radio- and Chemo-therapy NCT01549795 | Azienda Ospedaliera di Padova | N/A |
| Completed | Surveillance Study for Early Detection of Cholangiocarcinoma (CCA) in Primary Sclerosing Cholangitis (PSC) NCT03041662 | Karolinska University Hospital | — |
| Completed | Endomicroscopy in Primary Sclerosing Cholangitis Related Inflammatory Bowel Disease Surveillance NCT01880606 | Karolinska University Hospital | — |
| Unknown | Short-term Stenting Versus Balloon Dilatation for Dominant Strictures in Primary Sclerosing Cholangitis NCT01398917 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Phase 3 |
| Terminated | Pilot Study of Fenofibrate for PSC NCT01142323 | University of Miami | Phase 1 / Phase 2 |
| Completed | Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis NCT01088607 | University of Tennessee | Phase 1 |
| Recruiting | Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin NCT02137668 | Sacramento Pediatric Gastroenterology | Phase 1 |
| Completed | A Pilot Study of Vancomycin or Metronidazole in Patients With Primary Sclerosing Cholangitis NCT01085760 | Mayo Clinic | Phase 1 |
| Completed | Surgical Reconstruction in Ulcerative Colitis With Primary Sclerosing Cholangitis NCT01798953 | Sahlgrenska University Hospital | — |
| Completed | Erlotinib for Chemoprevention in Trisomy 7 Positive Primary Sclerosing Cholangitis (PSC) NCT00955149 | Mayo Clinic | Phase 1 |
| Completed | Endoscopic Ultrasound as an Early Diagnostic Tool for Primary Sclerosing Cholangitis NCT01556412 | Tischendorf, Jens, M.D. | — |
| Completed | Cholangioscopy Using Narrow Band Imaging (NBI) in Patients With Primary Sclerosing Cholangitis (PSC) Undergoin NCT00951327 | Mayo Clinic | — |
| Completed | Gastrointestinal Microbiota in Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin NCT01322386 | Stanford University | Phase 1 |
| Withdrawn | The Value of CT Cholangiography in Primary Sclerosing Cholangitis NCT00588458 | Mayo Clinic | Phase 2 |
| Terminated | Thalidomide for the Treatment of Primary Sclerosing Cholangitis (PSC) NCT00953615 | Mayo Clinic | Phase 2 |
| Completed | Evaluation of DHA for the Treatment of PSC NCT00325013 | Beth Israel Deaconess Medical Center | Phase 1 |
| Unknown | Probiotics in Patients With Primary Sclerosing Cholangitis NCT00161148 | UMC Utrecht | Phase 3 |
| Completed | NPDT Evaluation in Children With CFTR and (PSC) NCT00179439 | Beth Israel Deaconess Medical Center | — |
| Completed | Minocycline in Primary Sclerosing Cholangitis (PSC) NCT00630942 | Mayo Clinic | Phase 1 |
| Terminated | Trial of High-dose Urso in Primary Sclerosing Cholangitis NCT00059202 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Phase 2 / Phase 3 |
| Unknown | NPD Measurements in PSC Patients NCT00476814 | Hadassah Medical Organization | — |