NCT04753996

Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research is to create a collection of bile, bile duct brushings and medical information from people with Primary Sclerosing Cholangitis (PSC) and controls to learn more about changes that occur in the liver.

Detailed description

The study will ask participants to provide bile and/or bile duct cytology brushings at time of endoscopic retrograde cholangiopancreatography (ERCP) or cholecystectomy (gallbladder removal). The bile and brushings will be used to generate and perpetuate bile-derived organoids using an established matrigel-based protocol. These organoids will then be used in downstream experiments to better understand disease-specific alterations to biological pathways informative of disease pathogenesis

Conditions

• Primary Sclerosing Cholangitis
• PSC
• Cholangiocarcinoma

Timeline

• Start date: 2021-03-08
• Primary completion: 2035-01-01
• Completion: 2035-01-01
• First posted: 2021-02-15
• Last updated: 2026-02-17

Locations

1 site across 1 country: United States