NCT02247622

Telomere Length and Other Parameters of Telomere Dysfunction in PSC and Colitis

Primary Sclerosing Cholangitis Telomere Length

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Meir Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

PSC is a chronic cholestatic disorder. The investigators intend to study some telomere parameters and telomere length in order to predict a premalignant state.

Detailed description

Primary sclerosing cholangitis (PSC) and colitis are chronic inflammatory disorders with malignant potential. Telomerase is an enzyme complex that lengthens telomeres and has enhanced expression in numerous malignancies. In this study, we evaluated the telomerase gene copy number, telomere length, cells in senescence, aneuploidy and additional parameters of telomere dysfunction from peripheral blood lymphocytes of patients.

Conditions

• Primary Sclerosing Cholangitis
• Inflammatory Bowel Disease

Timeline

• Start date: 2012-02-01
• Primary completion: 2014-09-01
• Completion: 2014-09-01
• First posted: 2014-09-25
• Last updated: 2014-09-25

Locations

1 site across 1 country: Israel