| Not Yet Recruiting | A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs NCT07418034 | University of Maryland, Baltimore | Phase 2 |
| Recruiting | Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatme NCT07209189 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Phase 2 |
| Not Yet Recruiting | Surgery With or Without Neoadjuvant Treatment of SBRT Plus Chemoimmunotherapy in Resectable Locally Advanced O NCT07402538 | Sun Yat-sen University | Phase 3 |
| Recruiting | Toripalimab in Combination With Standard Treatment for Human Papillomavirus (HPV) Positive Throat Cancer NCT07290621 | University of Chicago | Phase 2 |
| Recruiting | Using CircuLating Tumor DNA to Risk Adapt Post-Operative Therapy for HPV-associated Oropharyngeal Cancer NCT06445114 | Zachary Zumsteg | Phase 2 |
| Recruiting | PIRATES: Image-guided Hyper-fractioned Dose-escalation With Proton Therapy for Head and Neck Cancer NCT06446713 | University Medical Center Groningen | Phase 1 |
| Recruiting | Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery NCT06747390 | Ryan Carey | Phase 1 |
| Not Yet Recruiting | Autologous T Cells Targeting HPV16 HPV18 & Survivin in Patients With R/R HPV-related Oropharyngeal Cancers NCT05582590 | NexImmune Inc. | Phase 1 |
| Recruiting | Biomarker Approach to Screening for the Early Detection of HPV-related Oropharyngeal Cancer (BASH OPC) NCT06305676 | H. Lee Moffitt Cancer Center and Research Institute | — |
| Unknown | Standard Pulsed Radiofrequency Versus Supervoltage Pulsed Radiofrequency Glossopharyngeal Nerve in Oropharynge NCT06121102 | National Cancer Institute, Egypt | N/A |
| Active Not Recruiting | BALSTILIMAB on Viral Clearance in HPV+ Oropharyngeal Cancer Patients NCT05363709 | M.D. Anderson Cancer Center | Phase 2 |
| Recruiting | Liposomal Bupivacaine and Transoral Robotic Surgery NCT05862792 | Geisinger Clinic | — |
| Recruiting | A Phase II Study for p16+ Oropharyngeal Cancer PerSonalized De-escalation Treatment at University of MIchigan NCT05894083 | University of Michigan Rogel Cancer Center | Phase 2 |
| Active Not Recruiting | A Study Using Human Papillomavirus (HPV) DNA Testing to Detect HPV-Related Oropharyngeal Cancer (OPC) NCT05814549 | Memorial Sloan Kettering Cancer Center | — |
| Unknown | HRYZ-T101 TCR-T Cell for HPV-18 Positive Advanced Solid Tumor NCT05787535 | HRYZ Biotech Co. | Phase 1 |
| Recruiting | SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer NCT05451004 | Canadian Cancer Trials Group | Phase 3 |
| Recruiting | A Study of Reduced Radiation Therapy and Standard-of-Care Chemotherapy in People With HPV-Positive Throat Canc NCT05491512 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Recruiting | Lymphatic Mapping Of Oropharyngeal Cancer NCT04498221 | University College, London | N/A |
| Unknown | PD-1 Inhibitor Based Induction Chemotherapy Followed by De-escalation Protocols in OPSCC NCT06156891 | Fudan University | Phase 2 |
| Recruiting | Role of Liquid Biopsies in HPV-associated Cancer Treatment Monitoring NCT05774561 | The Institute of Molecular and Translational Medicine, Czech Republic | — |
| Recruiting | Immune Biomarker Study for Head and Neck Cancer NCT05375266 | University of Erlangen-Nürnberg Medical School | — |
| Active Not Recruiting | A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Sm NCT04708470 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Completed | Prospective Study for the Prognostic and Predictive Role of Circulating Tumor Cells in Patients With Oropharyn NCT04696744 | Hospices Civils de Lyon | — |
| Completed | Evaluation of the Photobiomodulation Using LED Lamp for Curative Treatment of Radio-induced Mucositis. NCT04251949 | Centre Oscar Lambret | Phase 2 |
| Active Not Recruiting | Enhancing Self Care Among Oral Cancer Survivors: The Empowered Survival Trial NCT04713449 | Rutgers, The State University of New Jersey | N/A |
| Completed | HYHOPE: De-intensified Hypofractionated Radiation Therapy for HPV-associated Oropharynx Cancer NCT04580446 | University of Texas Southwestern Medical Center | Phase 1 |
| Completed | Postoperative Pain, Why Still in Hospital and DAOH Following TORS for SCCUP & OSAS NCT04189107 | Rigshospitalet, Denmark | Phase 3 |
| Active Not Recruiting | HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associ NCT04432597 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Unknown | Prevalence of Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) Following Squamous Cell Carcinomas of the Orop NCT04440618 | Poitiers University Hospital | — |
| Active Not Recruiting | Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies NCT04287868 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Recruiting | Assessment of Swallowing Function and Quality of Life in Oropharyngeal Cancer Patients Treated by Chemo-radiot NCT04019548 | Jules Bordet Institute | Phase 3 |
| Unknown | PEARL PET-based Adaptive Radiotherapy Clinical Trial NCT03935672 | Velindre NHS Trust | N/A |
| Active Not Recruiting | De-Escalation Radiotherapy in Patients With Low-Risk HPV-Related Oropharyngeal Squamous Cell Carcinoma NCT03822897 | Canadian Cancer Trials Group | Phase 2 |
| Completed | Molecular Signatures of HPV+ ORL Cancers (OROPAP) NCT04189003 | Assistance Publique - Hôpitaux de Paris | — |
| Terminated | TraceIT Tissue Marker to Mark the Primary Resection Bed Margins of Oropharyngeal Cancers NCT03713021 | Washington University School of Medicine | N/A |
| Completed | Functional Results of Soft Palate Free Flap Reconstruction NCT03890783 | Hospices Civils de Lyon | — |
| Active Not Recruiting | EValuating the Safety Of De-escaLated Head and Neck Irradiation in HPV positivE Oropharynx Cancer in Non-smoke NCT03777384 | Sanford Health | — |
| Active Not Recruiting | TORS De-Intensification Protocol Version 2.0: Dose and Volume Reduction in the Neck NCT03729518 | Abramson Cancer Center at Penn Medicine | N/A |
| Completed | Use of a Proliferation Saturation Index to Determine Personalized Radiotherapy for HPV + Oropharyngeal Cancers NCT03656133 | H. Lee Moffitt Cancer Center and Research Institute | N/A |
| Completed | Integrating a Health Information Technology System for Primary and Secondary Cervical Cancer Prevention NCT03346915 | Boston Medical Center | N/A |
| Terminated | CytID Analysis of Oral Lesions NCT03555721 | The University of Texas Health Science Center, Houston | — |
| Terminated | Utomilumab and ISA101b Vaccination in Patients With HPV-16-Positive Incurable Oropharyngeal Cancer NCT03258008 | M.D. Anderson Cancer Center | Phase 2 |
| Active Not Recruiting | Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer NCT03383094 | Loren Mell, MD | Phase 2 |
| Completed | M7824 in Subjects With HPV Associated Malignancies NCT03427411 | National Cancer Institute (NCI) | Phase 2 |
| Active Not Recruiting | Primary Radiotherapy Versus Primary Surgery for HPV-Associated Oropharyngeal Cancer NCT03210103 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Withdrawn | PROGRESS Trial - Prophylactic Gabapentin for Relief of Symptoms and Improved Swallowing NCT03423264 | University of Chicago | Phase 2 |
| Active Not Recruiting | Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Orop NCT03224000 | M.D. Anderson Cancer Center | Phase 2 |
| Unknown | Evaluation of HPV OncoTect ™ for the Etiological Diagnosis of HPV-induced Oropharyngeal Cancers NCT03604588 | Gustave Roussy, Cancer Campus, Grand Paris | N/A |
| Unknown | Comparative Effectiveness Trial of Transoral Head and Neck Surgery Followed by Adjuvant Radio(Chemo)Therapy Ve NCT03691441 | Universitätsklinikum Hamburg-Eppendorf | Phase 4 |
| Completed | Ficlatuzumab w/wo Cetuximab in Patients w/Cetuximab-Resistant, Recurrent or Metastatic Head/Neck Squamous Cell NCT03422536 | University of Arizona | Phase 2 |
| Active Not Recruiting | Study Assessing The "Best of" Radiotherapy vs the "Best of" Surgery in Patients With Oropharyngeal Carcinoma NCT02984410 | European Organisation for Research and Treatment of Cancer - EORTC | N/A |
| Completed | Speech-based AI-driven Diagnostics and Rehabilitation for Oral and Oropharyngeal Cancer. NCT07347899 | Yudong Xiao | — |
| Completed | Prospective, Multicenter da Vinci® SP™ Surgical System TORS Study NCT03049280 | Intuitive Surgical | N/A |
| Active Not Recruiting | Men and Women Offering Understanding of Throat HPV NCT03644563 | Johns Hopkins University | — |
| Unknown | uPAR PET/CT for Staging Advanced and Localised Oral and Oropharyngeal Cancer NCT02960724 | Rigshospitalet, Denmark | Phase 2 |
| Completed | Impact of HPV Vaccine On The Prevalence Of HPV In Norway NCT02934724 | Oslo University Hospital | — |
| Withdrawn | Cetuximab, Cisplatin and BYL719 for HPV-Associated Oropharyngeal Squamous Cell Carcinoma NCT02298595 | Julie E. Bauman, MD, MPH | Phase 1 / Phase 2 |
| Completed | Usefulness of Integrated PET/MRI in Oropharyngeal Squamous Cell Carcinoma Evaluation NCT05299957 | Chang Gung Memorial Hospital | — |
| Active Not Recruiting | CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC) NCT04116047 | University of Birmingham | Phase 3 |
| Completed | Establishing Lymphedema and Fibrosis Measures in Oral Cancer Patients NCT02412241 | Vanderbilt-Ingram Cancer Center | N/A |
| Completed | Improving Trans-oral Surgical Outcomes Through Intra-operative Image Guidance NCT02405000 | Dartmouth-Hitchcock Medical Center | N/A |
| Completed | Exosome Testing as a Screening Modality for Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinom NCT02147418 | New Mexico Cancer Research Alliance | — |
| Completed | HPV Vaccination: Evaluation of Reminder Prompts for Doses 2 & 3 NCT02558803 | Regenstrief Institute, Inc. | N/A |
| Completed | T Cell Receptor Immunotherapy Targeting HPV-16 E6 for HPV-Associated Cancers NCT02280811 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Terminated | Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma NCT02225496 | M.D. Anderson Cancer Center | Phase 2 |
| Completed | A Pilot Study at a Single-Institution of Pregabalin in the Management of Mucositis Pain in Patients Undergoing NCT02277548 | Abramson Cancer Center at Penn Medicine | N/A |
| Completed | HPV Vaccination: An Investigation of Physician Reminders and Recommendation Scripts NCT02551887 | Regenstrief Institute, Inc. | N/A |
| Completed | A Single-arm Phase II Study of Post-Transoral Robotic Surgery (TORS) Alone to the Primary Tumor Site and Selec NCT02159703 | Abramson Cancer Center at Penn Medicine | Phase 2 |
| Recruiting | Integrated Cancer Repository for Cancer Research NCT02012699 | University of Nebraska | — |
| Withdrawn | Modified Barium Swallow in Measuring Swallowing Function After Surgery in Patients With Oropharyngeal Cancer NCT01767961 | Wake Forest University Health Sciences | N/A |
| Unknown | Obstructive Sleep Apnea Syndrome After Oropharyngeal Cancer Treatment NCT02881723 | Assistance Publique Hopitaux De Marseille | N/A |
| Completed | 18F-FDG-PET Guided Dose-Painting With Intensity Modulated Radiotherapy in Oropharyngeal Tumours NCT02953197 | Guy's and St Thomas' NHS Foundation Trust | Phase 1 |
| Completed | Trismus Trial of Therabite vs Wooden Spatula in Head and Neck Cancer Patients NCT01733797 | Brynn Chappell | Phase 2 |
| Terminated | Acupuncture in Reducing the Severity of Chemoradiation-induced Mucositis in Patients With Oropharyngeal Cancer NCT01883908 | University of Maryland, Baltimore | N/A |
| Withdrawn | Reflux Disease in Head and Neck Cancer Patients Undergoing Radiation Therapy NCT00928161 | M.D. Anderson Cancer Center | N/A |
| Withdrawn | Complete Decongestive Therapy (CDT) for Treatment of Head and Neck Lymphedema NCT00951470 | M.D. Anderson Cancer Center | N/A |
| Completed | Valproic Acid and Platinum-based Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma NCT01695122 | Instituto do Cancer do Estado de São Paulo | Phase 2 |
| Completed | Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Human Papillomavirus-Associate NCT01585428 | National Cancer Institute (NCI) | Phase 2 |
| Unknown | Safety and Efficacy Study of Nimotuzumab Plus Neoadjuvant and Concurrent Chemoradiotherapy to Treat Oropharynx NCT01516996 | The Second People's Hospital of Sichuan | Phase 2 |
| Completed | A Phase II Study In Patients With Advanced Head And Neck Cancer Of Standard Chemoradiation And Add-On Cetuxima NCT01435252 | University of Zurich | Phase 2 |
| Completed | Respiratory-Swallow Training in Veterans With Oropharyngeal Cancer NCT01032928 | US Department of Veterans Affairs | Phase 2 |
| Completed | Role of Immune Activation in Response of Head and Neck Squamous Cell Carcinoma to Therapy NCT01358097 | Icahn School of Medicine at Mount Sinai | — |
| Withdrawn | Concordance of Two Endoscopic Procedures for Diagnosis of Carcinoma of the Upper Aerodigestive Tract NCT01175499 | University of California, San Francisco | N/A |
| Completed | Effectiveness of Adjuvant Radiotherapy in Small Oropharyngeal Squamous Cell Cancer and Single Lymph Node Metas NCT00964977 | Johannes Gutenberg University Mainz | Phase 3 |
| Completed | Human Papillomavirus (HPV) Oral Transmission Study in Partners Over Time NCT01342978 | Johns Hopkins Bloomberg School of Public Health | — |
| Completed | Physiotherapy Treatment for Patients Suffering From Head and Neck Cancer NCT00780312 | Rigshospitalet, Denmark | Phase 2 |
| Unknown | Sexual Behavior in Head and Neck Cancer Patients NCT00662662 | M.D. Anderson Cancer Center | — |
| Completed | Nicotine Levels With Response Rates to Radiation Alone or With Chemo In Head & Neck Cancer NCT01084733 | Mahesh Kudrimoti | — |
| Completed | A Pilot Trial of Image-Guided Adaptive Radiotherapy for Head and Neck Cancer NCT00490282 | M.D. Anderson Cancer Center | N/A |
| Completed | Robotic Assisted Surgery in Upper Aerodigestive Tract Surgery NCT00473564 | University of Alabama at Birmingham | N/A |
| Completed | Sexual Behavior in Oropharyngeal Patients Versus Head and Neck Cancer Patients, With or Without HPV Infection NCT00508170 | M.D. Anderson Cancer Center | — |
| Active Not Recruiting | Depression and Adherence in Head and Neck Cancer NCT00498875 | M.D. Anderson Cancer Center | — |
| Completed | Gene Therapy in Preventing Cancer in Patients With Premalignant Carcinoma of the Oral Cavity or Pharynx NCT00064103 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Withdrawn | ONYX-015 With Cisplatin and Fluorouracil in Treating Patients With Advanced Head and Neck Cancer NCT00006106 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Bowman-Birk Inhibitor Concentrate in Preventing Cancer in Patients With Oral Leukoplakia NCT00330382 | National Cancer Institute (NCI) | Phase 2 |