| Not Yet Recruiting | IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success NCT07494838 | Lucas R. Cusumano, MD | N/A |
| Recruiting | Advanced Brain Imaging-TKA (fMRI-TKA) NCT07464080 | Ottawa Hospital Research Institute | N/A |
| Not Yet Recruiting | Effects of Photobiomodulation and Topical Diclofenac on Inflammation and Pain in Knee Osteoarthritis (EPIC-KO) NCT07079969 | University of Florida | Phase 2 |
| Completed | Investigation of the Effectiveness of Myofascial Release Techniques Applied to the Popliteus Muscle in Individ NCT07474597 | Istanbul Rumeli University | N/A |
| Not Yet Recruiting | Knee Pain Relief After Endovenous Treatment for Lower Limb Varicose Veins: A Prospective Observational Study NCT07163312 | Chengdu University of Traditional Chinese Medicine | — |
| Recruiting | Impact of Dexamethasone Route on Pain and Inflammation in iPACK With ACB for Knee Arthroplasty NCT07180953 | Poznan University of Medical Sciences | Phase 4 |
| Recruiting | Pain Reprocessing Therapy in Post-Operative Knee Pain NCT06800209 | University of Colorado, Denver | Phase 2 |
| Recruiting | Light Therapy on Pain and Synovitis NCT07057063 | The Hong Kong Polytechnic University | N/A |
| Recruiting | BioPoly® Partial Resurfacing Knee Implant IDE NCT06915363 | BioPoly LLC | N/A |
| Recruiting | Efficacy of Microparticle Geniculate Artery Embolization in Total Knee Prosthesis Patients With Pain Resistant NCT06466330 | Societe Francaise de Rhumatologie | N/A |
| Active Not Recruiting | Association Of Knee Pain With High-Impact Workouts Among Gym Participants: A Cross-Sectional Study NCT07055750 | Superior University | — |
| Withdrawn | Genicular Artery Embolization (GAE) for Osteoarthritic Knee Pain NCT04472091 | Andrew Picel | N/A |
| Completed | The Acute Effects of Ankle Exercises on Knee Proprioception NCT07194031 | Gaziantep Islam Science and Technology University | N/A |
| Completed | Two-level ESPB in Total Knee Arthroplasty NCT06470542 | Poznan University of Medical Sciences | Phase 4 |
| Completed | Effects of UC-II, Glucosamine and Curcumin Supplementation on Knee Pain and Inflammation. NCT06581094 | Taipei Medical University | N/A |
| Recruiting | Evaluation Study for the "Jockey Club E-Generation: Impact Extension Project for Chronic Knee Pain Management" NCT06569836 | The University of Hong Kong | N/A |
| Completed | Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Knee Arthroplasty NCT06470100 | Poznan University of Medical Sciences | Phase 4 |
| Completed | Dexamethasone for iPACK Block With ACB in Total Knee Arthroplasty NCT06470204 | Poznan University of Medical Sciences | Phase 4 |
| Completed | Computer-guided Action Planning to Support Physical Activity (CAPPA) for Employees With Chronic Knee Symptoms NCT06734052 | Marquette University | N/A |
| Not Yet Recruiting | Evaluation of the Effectiveness of Genicular Block in Postoperative Analgesia in Patients Undergoing Knee Arth NCT06413446 | Başakşehir Çam & Sakura City Hospital | — |
| Recruiting | Transcranial Direct Current Stimulation in Conjunction with Individualized Physical Therapy for Individuals wi NCT06132412 | University of Illinois at Chicago | N/A |
| Recruiting | Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty NCT06123715 | University Health Network, Toronto | Phase 2 |
| Unknown | ESPB vs iPACK+ACB in Total Knee Arthroplasty NCT06302218 | Poznan University of Medical Sciences | Phase 4 |
| Completed | NLR and PLR Levels Following IPACK Block in Knee Arthroplasty NCT06304298 | Poznan University of Medical Sciences | Phase 4 |
| Completed | Erector Spinae Plane Block Vs. IPACK Block with Adductor Canal Block for Total Knee Arthroplasty NCT06233630 | Poznan University of Medical Sciences | Phase 4 |
| Completed | Effects of IASTM With and Without CT on Pain, ROM, and Functional Disability in Post-Operative Knee Stiffness NCT06551922 | University of Lahore | N/A |
| Completed | Ultrasound-Guided Adductor Canal Block for Total Knee Arthroplasty Surgery NCT06084403 | Bursa City Hospital | N/A |
| Recruiting | Optimizing Pain Self-Management in Total Knee Arthroplasty NCT06038240 | University of Virginia | N/A |
| Recruiting | RFA or Chemical Neurolysis of the Genicular Nerves Compared to Conservative Treatment for Knee Pain Caused by NCT06094660 | Dijklander Ziekenhuis | N/A |
| Recruiting | Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis NCT06105788 | University of Texas, El Paso | N/A |
| Not Yet Recruiting | Finding the Optimal Aim of Correction in Opening Wedge High Tibial Osteotomy NCT06134050 | Vestre Viken Hospital Trust | N/A |
| Withdrawn | Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis NCT05742763 | QC Kinetix LLC | Phase 1 / Phase 2 |
| Unknown | Comparison of Concentric-eccentric Exercises in Patellofemoral Pain Syndrome NCT06197958 | Riphah International University | N/A |
| Recruiting | The Effect of RF Genicular Nerve Block Applied in the Preoperative Period on Fast-track Total Knee Arthroplast NCT06239649 | Pamukkale University | — |
| Completed | The Cartilage and Muscle Thickness on Knee Pain in Patients With Rheumatoid Arthritis NCT05999266 | Sisli Hamidiye Etfal Training and Research Hospital | — |
| Completed | Paraffin Wax Bath With Joint Mobilization Technique in Post-traumatic Stiff Knee NCT06049303 | Riphah International University | N/A |
| Unknown | Effects of Virtual Reality Rehabilitation and Muscle Energy Technique in Patients With Patellofemoral Pain Syn NCT05971966 | Riphah International University | N/A |
| Active Not Recruiting | Cemented vs Cementless Persona Keel RCT NCT05630053 | Zimmer Biomet | N/A |
| Unknown | Vastus Medialis Activation During McMurray's Test NCT05965804 | Ahram Canadian University | — |
| Recruiting | Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty) NCT05787821 | Zimmer Biomet | — |
| Withdrawn | A Randomized Controlled Trial for Partial Knee Arthroplasty NCT05037734 | Zimmer Biomet | N/A |
| Active Not Recruiting | Maximizing Patient Goal Attainment NCT05652270 | Dartmouth-Hitchcock Medical Center | N/A |
| Completed | The Effectiveness of Using a Clinical Support Tool in Managing Adolescents With Non-Traumatic Knee Pain NCT05791513 | Aalborg University | N/A |
| Completed | Efficacy of Genicular Nerve Alcohol Neurolysis in Knee Osteoarthritis Pain NCT06060678 | Diskapi Teaching and Research Hospital | — |
| Unknown | Effects of Multi Radiance Medical® Super Pulsed Laser on Chronic Knee Pain NCT05830344 | University of Nove de Julho | N/A |
| Active Not Recruiting | HFIT Versus TENS Study for Chronic Low Back and Knee Pain NCT05821530 | Hinge Health, Inc | N/A |
| Unknown | Prevention, Management and Rehabilitation of Knee Osteoarthritis at the Workplace NCT05822401 | National Research Centre for the Working Environment, Denmark | N/A |
| Recruiting | Intra-Operative Adductor Canal Blocks NCT05601427 | Ottawa Hospital Research Institute | N/A |
| Completed | Quantum Molecular Resonance (QMR) Rehabiltative Treatment of Knee Osteoarthritis NCT06239805 | G. d'Annunzio University | N/A |
| Completed | The Relationship of the Medial Longitudinal Arch Height With Clinical Features of Knee Osteoarthritis NCT05656014 | Gazi University | — |
| Unknown | Cryoneurolysis for TKA - a Pilot Study NCT05286996 | Unity Health Toronto | N/A |
| Recruiting | Focused Extracorporeal Shockwave Therapy for Knee Arthritis NCT05596591 | Kessler Foundation | N/A |
| Unknown | Genicular RFT vs Phenol Management in Patients With Knee Osteoarthritis NCT05908942 | Diskapi Teaching and Research Hospital | — |
| Withdrawn | Genicular Artery Embolization (GAE) for the Treatment of Chronic Post Knee Arthroplasty Pain NCT05248308 | Brigham and Women's Hospital | N/A |
| Withdrawn | Can Simplified and More Detailed Instructions Affect Post-Operative Narcotic Consumption NCT03534102 | Brigham and Women's Hospital | Phase 4 |
| Completed | A Study of the Feasibility of Using the Dietary Supplement "ARTNEO" in Patients With Osteoathritis NCT05975879 | NPO Petrovax | N/A |
| Unknown | The Effect of PEMF for Patients With Knee OA NCT05548712 | Chinese University of Hong Kong | N/A |
| Recruiting | SMART Embedded Intervention for Military Postsurgical Engagement Readiness NCT05050409 | University of Utah | N/A |
| Unknown | Outcome Measures of Pulsed Radiofrequency of the Genicular Nerves When Performed With and Without Concomitant NCT04940832 | Sheba Medical Center | N/A |
| Unknown | The Effect of Physical Therapy Modalities and Kinesio Taping in Patients With Knee Osteoarthritis NCT05211544 | Abant Izzet Baysal University | N/A |
| Active Not Recruiting | Dorsal Root Ganglion Stimulation for the Treatment of Arthritic Knee Pain NCT05103527 | Kenneth B Chapman | N/A |
| Completed | Lyophilized and Micronized Particulate Human Amniotic and Umbilical Cord (TTAX03) for KL Grade 3-4 Knee OA NCT05079035 | BioTissue Holdings, Inc | Phase 2 |
| Unknown | Study to Evaluate Intra-articular Resiniferatoxin to Treat Moderate to Severe Pain From Knee Osteoarthritis NCT04885972 | Sorrento Therapeutics, Inc. | Phase 2 |
| Unknown | Phenol Neurolysis of Genicular Nerves for Osteoarthritic Knee Pain NCT04989660 | Kessler Foundation | Phase 4 |
| Unknown | Clinical Applications of Blood Flow Restriction and Rehabilitation Outcomes NCT04989023 | Aspetar | N/A |
| Unknown | The Effects of Home Use of Transcutaneous Electrical Nerve Stimulation on People With Knee OA and or Chronic K NCT05062499 | Omron Healthcare Co., Ltd. | N/A |
| Withdrawn | Using Peripheral Nerve Stimulation (PNS) to Treat Chronic Post-surgical Pain (CPSP) After Knee Surgery NCT04670042 | Stanford University | N/A |
| Active Not Recruiting | Persona Ti-Nidium Post-Market Clinical Follow-up NCT04817969 | Zimmer Biomet | N/A |
| Completed | The Use of Venlafaxine in Reducing Pain in Primary Total Knee Replacement NCT05023278 | University of California, San Francisco | Phase 4 |
| Withdrawn | Study to Evaluate Resiniferatoxin in Patients With Knee Osteoarthritis Whose Total Knee Replacement Surgery is NCT04386980 | Sorrento Therapeutics, Inc. | Phase 3 |
| Completed | A Comparison of Ultrasound Guided Genicular Nerve Blockade Using Current Versus Revised Anatomical Targets NCT05073887 | Diskapi Teaching and Research Hospital | N/A |
| Completed | Maladaptive Psychosocial Beliefs and Adolescents With Patellofemoral Pain NCT04752501 | Nationwide Children's Hospital | N/A |
| Recruiting | Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Tot NCT04814082 | LifeBridge Health | N/A |
| Completed | Femoral Rotation and Patellar Positioning After TKA NCT05871112 | Medical University of Warsaw | — |
| Withdrawn | A Phase 3 Study to Evaluate the Efficacy and Safety of Resiniferatoxin for Pain Due to Osteoarthritis of the K NCT04044742 | Sorrento Therapeutics, Inc. | Phase 3 |
| Completed | Robotic-assisted Total Knee Arthroplasty vs. Conventional One NCT04611815 | Medical University of Warsaw | N/A |
| Completed | Molecular Pathways Involved in Knee Pain NCT04443452 | University of Nottingham | — |
| Completed | Chronic Pain and Functional Prognosis After Total Knee Replacement: Continuous Locoregional Analgesia by Cathe NCT03998813 | Centre Hospitalier Departemental Vendee | N/A |
| Completed | ROMTECH PortableConnect Rehabilitation Device Usage Post Unilateral Total Knee Arthroplasty (TKA) NCT04497129 | ROM Technologies, INC | N/A |
| Completed | Gold Factor on Knee Joint Health and Function NCT05347602 | 4Life Research, LLC | N/A |
| Completed | Pain Management After Adductor Canal Block for Total Knee Arthroplasty NCT06086483 | Poznan University of Medical Sciences | Phase 4 |
| Unknown | iPACK Block for Total Knee Arthroplasty NCT06087562 | Poznan University of Medical Sciences | Phase 4 |
| Completed | Efficacy of High and Low Intensity Percutaneous Electrolysis for the Treatment of Myofascial Pain Syndrome NCT04390438 | Universidad Francisco de Vitoria | N/A |
| Active Not Recruiting | Prophylactic Infrapatellar Saphenous Neurectomy in Primary Total Knee Arthroplasty NCT04028947 | Mayo Clinic | N/A |
| Withdrawn | Ultrasound-Guided Adductor Canal Block for Total Knee Arthroplasty Surgery NCT04189640 | Medipol University | N/A |
| Withdrawn | Kinematic Alignment vs Mechanical Alignment for Total Knee Arthroplasty NCT05461638 | Medacta USA | N/A |
| Completed | Pulsed Radiofrequency and Osteoarthritic Chronic Knee Pain NCT04454710 | University of Rome Tor Vergata | N/A |
| Unknown | Rate of Torque Development and Voluntary Quadriceps Activation in Patients With Knee Osteoarthritis: A Quantit NCT04234282 | Jennifer Moreno Clinic | N/A |
| Unknown | Effectiveness of Curcumin-based Food Supplement in Reducing Pain and Inflammatory Component in Osteoarthritis NCT04207021 | KOS Care SRL - Istituto di Riabilitazione Santo Stefano | N/A |
| Terminated | Cognition, Pain and Wellbeing NCT04620525 | University of Nottingham | — |
| Unknown | Effectiveness of a Walking Intervention on Impact Loading and Pain NCT04148807 | Northeastern University | N/A |
| Completed | Effect of Short-term Motor Training on Accuracy and Precision of Knee Movement in Human With and Without Knee NCT04146311 | Aalborg University | N/A |
| Completed | Dutch Version Fear-Avoidance Component Scale (FACS) NCT03994861 | Hasselt University | N/A |
| Completed | Cognitive Flexibility Training for Persistent Pain: Neuroimaging Pilot (COFLEX-i) NCT03720821 | Washington University School of Medicine | N/A |
| Terminated | NEAT!2 Sedentary Behavior Reduction for Individuals With Past or Present Knee Symptoms, Injuries, or Surgeries NCT03987932 | University of South Carolina | N/A |
| Completed | Evaluation of NMES for Reducing Pain and Improving Functional Outcomes in Knee OA Patients NCT03980964 | CyMedica Orthopedics, Inc | N/A |
| Terminated | NUsurface Implant Registry NCT03953846 | Active Implants | — |
| Completed | Effects of Internet / Web-based Exercises on the Population With Knee Arthritis NCT03545048 | University of Nottingham | N/A |
| Unknown | Knee Arthritis Treatment With Autologous Fragmented Adipose Tissue and PRP - Comparison of Two Treatment Metho NCT04321629 | Rehasport Clinic | Phase 2 |
| Completed | Ultrasound-guided Genicular Nerve Block for Total Knee Arthroplasty (GenTKR) NCT04024319 | Hospital Clinic of Barcelona | — |
| Completed | Gabapentin Regimens and Their Effects on Opioid Consumption NCT03334903 | Brigham and Women's Hospital | Phase 4 |
| Unknown | Effect of Buglossoides Oil on Recent Chronic Non-injurious Hip and Knee Pain NCT03576625 | Réseau de Santé Vitalité Health Network | Phase 1 |
| Completed | Impact of Home Exercise Delivery on Compliance & Outcomes for Musculoskeletal Pain NCT03470753 | Dan Rhon | N/A |
| Completed | Effect of Implanting Allogenic Cytokines Derived From Human Amniotic Membrane (HAM) and Mesenchymal Stem Cells NCT03337243 | Sport and Spine Rehab Clinical Research Foundation | N/A |
| Active Not Recruiting | Performance of MOTO Medial® Unicompartmental Knee Arthroplasty NCT03211663 | Medacta USA | — |
| Completed | Arthroscopic Versus Conservative Treatment of Degenerative Meniscal Tear in Middle Aged Patients in Regard to NCT04313569 | Hawler Medical University | N/A |
| Withdrawn | Platelet-rich Plasma Injections for Persistent Medial Knee Pain After Total Knee Arthroplasty NCT03225092 | Ohio State University | EARLY_Phase 1 |
| Completed | AP-003-C Study to Confirm the Efficacy of Ampion™ in Adults With Pain Due to Severe Osteoarthritis of the Knee NCT03182686 | Ampio Pharmaceuticals. Inc. | Phase 3 |
| Completed | Subchondroplasty® Knee RCT NCT03112200 | Zimmer Biomet | N/A |
| Unknown | Adolescent Anterior Knee Pain: ARP Wave Therapy vs. Physical Therapy NCT03225014 | Rady Children's Hospital, San Diego | N/A |
| Completed | Clinical Outcome of Arthroscopic Lateral Release for Lateral Patellar Compression Syndrome NCT04313556 | Hawler Medical University | N/A |
| Completed | Outcome After Total Knee Arthroplasty Under General or Spinal Anesthesia NCT03364088 | Riku Antero Palanne | N/A |
| Completed | Anterior Knee Pain Between Unisex Knee Prosthesis VS Gender Specific Knee Prosthesis Following MIS TKA NCT05045651 | Thammasat University | N/A |
| Unknown | Shock Wave Therapy Versus Neuromuscular Training in Women With Patellofemoral Pain NCT03324204 | Medical University of Silesia | N/A |
| Active Not Recruiting | Persona Total Knee Arthroplasty Outcomes Study NCT02255383 | Zimmer Biomet | N/A |
| Unknown | Treatment of Knee Pain With Topical Diclofenac Cream 8% or Diclofenac Gel 1% NCT02068859 | FPR Specialty Pharmacy | Phase 3 |
| Completed | Supporting Decision Making for Musculoskeletal Preference-Sensitive Care NCT01345123 | Health Dialog | N/A |
| Completed | Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Knee Pain NCT01351805 | Brigham and Women's Hospital | N/A |
| Completed | Knee Pain After Intramedullary Nailing in the Tibia NCT03649360 | Copenhagen University Hospital, Hvidovre | — |
| No Longer Available | Individual Patient Expanded Access IND of Autologous HB-adMSCS for the Treatment of Bilateral Knee Pain. NCT04604288 | Hope Biosciences Research Foundation | — |