Trials / Recruiting
RecruitingNCT07464080
Advanced Brain Imaging-TKA (fMRI-TKA)
Brain Network-based Precision Medicine to Predict Dissatisfaction Following Total Knee Arthroplasty
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- Sponsor
- Ottawa Hospital Research Institute · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities. Currently, clinicians cannot reliably predict which patients will experience these challenges. This study uses MRI scan of the brain to investigate whether specific patterns of brain activity can predict patient satisfaction after total knee arthroplasty (TKA). By comparing brain networks before surgery and afterward, and linking these changes to patient-reported pain and function, we aim to identify brain-based markers that can help predict outcomes, to improve satisfaction after knee replacement surgery.
Conditions
- Knee Osteoarthritis (Knee OA)
- Knee Pain Chronic
- Brain Network Connectivity
- Patient Satisfaction
- Brain MRI
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | fMRI Brain Scan | A research brain MRI scan will be performed on a 3T scanner. The MRI session will take approximately 50 minutes of scanning time. The MRI scan will be repeated again 2 months after surgery. |
Timeline
- Start date
- 2026-04-01
- Primary completion
- 2027-12-31
- Completion
- 2028-12-31
- First posted
- 2026-03-11
- Last updated
- 2026-03-11
Locations
1 site across 1 country: Canada
Source: ClinicalTrials.gov record NCT07464080. Inclusion in this directory is not an endorsement.