| Recruiting | Renal and Hepatic Abnormal Doppler Patterns in Trauma NCT07492511 | Azienda Usl di Bologna | — |
| Not Yet Recruiting | Evaluate Recombinant Human Serum Albumin From Oryza Sativa In Patients With Hypoalbuminemia and/or Hypovolemia NCT07435922 | Healthgen Biotechnology Corp. | — |
| Not Yet Recruiting | Role of End-Tidal CO2 During Passive Leg Raising to Predict Fluid Responsiveness in ICU NCT07304648 | Izmir Katip Celebi University | — |
| Not Yet Recruiting | Comparison of PPV and LVOT VTI During Passive Leg Raising to Predict Fluid Responsiveness NCT07304661 | Izmir Katip Celebi University | — |
| Not Yet Recruiting | IVC Ultrasound Versus Central Venous Pressure for Early Detection of Hypovolemia in Shock Patients NCT07206732 | Assiut University | — |
| Active Not Recruiting | Reliability of Internal Jugular Ultrasound : an Observational Transversal Study Conducted Using Images Registe NCT06591234 | Maggiore Bellaria Hospital, Bologna | — |
| Recruiting | A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients Wit NCT06072430 | Vivacelle Bio | Phase 3 |
| Completed | Ultrasound Guided Fluid Loading Before Spinal Anesthesia NCT07108881 | University Tunis El Manar | Phase 4 |
| Unknown | Acetated Ringer´s Solution in Experimental Hypovolemia NCT05705115 | Oslo University Hospital | Phase 4 |
| Recruiting | Hemodynamic Monitoring During Craniosynostosis Surgery: Comparing Traditional and Newer Technology Monitors (C NCT06263075 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Recruiting | Early Initiated Vasopressor Therapy in the Emergency Department NCT05931601 | Odense University Hospital | Phase 3 |
| Completed | Use of Heart-lung Interaction to Predict Haemodynamic Tolerance to the Open Lung Approach With Individualised NCT06123039 | Hospital Universitario La Fe | — |
| Completed | Arterial Pressure Derived Dynamic Parameters to Detect Preload Responsiveness in Spontaneously Breathing Patie NCT06480942 | CHU de Reims | — |
| Recruiting | Effectiveness of the Pressure Recording Analytical Method in Predicting Fluid Responsiveness in Pediatric Crit NCT04186416 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Fluid Responsiveness Tests in Critically Ill Patients During Admission to the Intensive Care Unit NCT06729268 | Uniwersytecki Szpital Kliniczny w Opolu | — |
| Completed | Interest of the Pleth Variability Index in Neurosurgery NCT06624891 | National Institute of Neurology, Tunisia | N/A |
| Unknown | Assessment of Fluid Responsiveness in Septic Shock Patients, Can End-tidal co2 Measurement Help? NCT05557461 | Bozyaka Training and Research Hospital | — |
| Completed | Photoplethysmography for Diagnose Incipient Hypovolemia NCT05512611 | Hospital Privado de Comunidad de Mar del Plata | — |
| Completed | Effect of Preoperative Fluid Therapy on Post-induction Hypotension NCT06231472 | Mustafa Burgac | N/A |
| Completed | Supplemental Oxygen in Hypovolemia NCT05150418 | Oslo University Hospital | Phase 1 |
| Completed | Effects of Different Fluid Transfusion Regimens On Glycocalyx In Patients Undergoing Thoracic Surgery. NCT07192523 | Kocaeli Derince Education and Research Hospital | N/A |
| Unknown | Predicting Fluid Responsiveness in Mechanically Ventilated Critically Ill Children Using Transthoracic Echocar NCT05054452 | Assistance Publique - Hôpitaux de Paris | N/A |
| Unknown | Analysis of Passive Leg Raise Test on Blood Pressure in Critically Ill Patients. NCT05554783 | Medical University of Gdansk | — |
| Completed | Spectral Analysis of Central Venous Pressure Waveform NCT04733547 | JongHae Kim | — |
| Completed | Ultrasound Assessment of the Subclavian Vein for Predicting Hypotension in Children After Anaesthesia Inductio NCT04573842 | Karolinska Institutet | — |
| Completed | Methoxyflurane and Fentanyl in LBNP NCT04641949 | Oslo University Hospital | Phase 4 |
| Withdrawn | Monitoring Noninvasively for Infusion and Transfusion Optimization NCT04388722 | Masimo Corporation | N/A |
| Completed | Prediction of the Effect of Fluid Administration Using Arterial Pressure and Ventilator Data During Abdominal NCT04298931 | University of Aarhus | — |
| Unknown | VBI-S for the Treatment of Hypotension in Hypovolemic Septic Shock Patients NCT04257136 | Vivacelle Bio | Phase 2 |
| Completed | Dynamic Parameters in Evaluation of Fluid Responsiveness NCT04283851 | Charles University, Czech Republic | — |
| Completed | Changes in Serum Creatinine Levels Can Help Distinguish Hypovolemic From Euvolemic Hyponatremia NCT04744987 | Hospital San Carlos, Madrid | — |
| Completed | Ventricular Stimulation as Predictor of Hypovolemia After Cardiac Surgery NCT03926910 | CMC Ambroise Paré | N/A |
| Completed | Clinical Validation of Algorithms for Mean Systemic Filling Pressure and Automated Cardiac Output NCT04202432 | Catharina Ziekenhuis Eindhoven | — |
| Completed | Autonomic Challenges From Mild Hypovolemia and Mechanical Ventilation NCT03244891 | ASST Fatebenefratelli Sacco | N/A |
| Completed | Determination of Analgesic Equipotent Doses of Inhaled Metoxyflurane vs. Intravenous Fentanyl NCT03894800 | Oslo University Hospital | Phase 4 |
| Completed | Bedside Resources to Gauge Intravascular Volume Status NCT03915587 | University of Colorado, Denver | N/A |
| Terminated | Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervol NCT03736421 | Beth Israel Deaconess Medical Center | — |
| Completed | Perioperative Fluid Therapy Optimization in Spinal Surgery NCT03644654 | University Hospital Hradec Kralove | N/A |
| Completed | The Use of an External Ultrasound Fixator (ProbeFixR) on Intensive Care Patients NCT03497754 | Rijnstate Hospital | N/A |
| Completed | Detection of Hypovolemia in the Elderly Patient Undergoing Surgery NCT06229938 | Amsterdam UMC, location VUmc | — |
| Unknown | Hemodynamic Changes Induced by Alveolar Recruitment Maneuver With Respect to Volemic State in Colon Surgery NCT03468764 | IRCCS San Raffaele | — |
| Completed | Prevalence of Hypovolemia and Heart Failure in Non-cardiac Surgery NCT03349593 | Umeå University | — |
| Withdrawn | Impact of GDT in Robot-assisted Laparoscopic Urological Surgery for Low to Moderate Risk Patients NCT03213574 | Loma Linda University | N/A |
| Recruiting | Hemodynamics Monitoring During Lower Body Negative Pressure (LBNP) Induced Controlled Hypovolemia NCT03592290 | Yale University | — |
| Completed | Plasma-Lyte 148® versUs Saline Study NCT02721654 | The George Institute | Phase 4 |
| Completed | Lung Recruitment Maneuver for Predicting Fluid Responsiveness in Children NCT03184961 | Seoul National University Hospital | N/A |
| Completed | Fluid Responsiveness Using Forehead Sensor in Children NCT03132480 | Seoul National University Hospital | N/A |
| Unknown | A Prospective Observational Study of the Expectations and Physiological Effects of Fluid Bolus Therapy NCT03178578 | Karolinska Institutet | — |
| Completed | Prediction of Fluid Responsiveness in Children Undergoing Major Surgery NCT02952651 | Seoul National University Hospital | N/A |
| Unknown | Diagnosis Accuracy of Abdominal Compression and Hemoconcentration to Detect Diuretic Induced Fluid Removal Int NCT03145935 | Hopital Louis Pradel | — |
| Unknown | Pilot Validation of a Hemodilution Technique to Estimate Blood Volume in Vivo NCT03031600 | Uniformed Services University of the Health Sciences | N/A |
| Completed | Hemodynamic Effects of Cold Versus Warm Fluid Bolus NCT03209271 | Karolinska Institutet | N/A |
| Completed | Prediction of Fluid Responsiveness in Children With Single Ventricle NCT02826135 | Seoul National University Hospital | N/A |
| Unknown | Diagnosis Accuracy of Hemoconcentration to Detect Hypovolemia During CRRT NCT03144349 | Hopital Louis Pradel | — |
| Completed | Validation of Epworth Richmond's Echocardiography Education Focused Year NCT02961439 | Epworth Healthcare | — |
| Completed | Predicting Fluid Responsiveness in on Pump Coronary Artery Bypass Graft Using Extra Systoles NCT02903316 | University of Aarhus | — |
| Withdrawn | Influence of Mechanical Ventilation Mode on Arterial Pressure Variations- a Pilot Study NCT03246425 | State University of New York - Upstate Medical University | N/A |
| Suspended | Hemodynamic Assessment During Spinal Anesthesia Using Transthoracic Echocardiography' NCT02315937 | Catharina Ziekenhuis Eindhoven | — |
| Unknown | Patient Controlled Fluid Administration NCT03176043 | University College, London | EARLY_Phase 1 |
| Completed | Assessment of Arterial Dynamic Elastance as a Function Variable of Arterial Load NCT02774304 | Universitair Ziekenhuis Brussel | N/A |
| Completed | Comparison of the Effects of an Hypertonic Solution With Ringer Lactate on Right Ventricular Function Followin NCT02782520 | University Hospital, Grenoble | Phase 3 |
| Completed | Non-invasive Cardiac Output Monitor in Young Adults NCT02813915 | Indiana University | — |
| Completed | Study on the Efficacy and Safety of Gelaspan NCT02808325 | B. Braun Medical LLC | Phase 3 |
| Completed | Focused Assessed Echocardiography to Predict Fluid Responsiveness NCT03044405 | Lithuanian University of Health Sciences | N/A |
| Terminated | Gelatin in ICU and Sepsis NCT02715466 | B. Braun Melsungen AG | Phase 4 |
| Completed | Fluid Responsiveness After CArdiac Surgery Study NCT02841943 | South West Sydney Local Health District | — |
| Completed | Preload Dependency Evaluation With Stroke Volume Variation During Alveolar Recruitment Manoeuvres NCT02678559 | University Hospital, Clermont-Ferrand | N/A |
| Terminated | RApid Fluid Volume EXpansion in Patients in Shock After the Initial Phase of Resuscitation. NCT02645851 | Centre Hospitalier Régional d'Orléans | N/A |
| Completed | The Impact of Focused Transthoracic Echocardiography in Urgent Abdominal Surgery for Septic Patients NCT02846948 | Lithuanian University of Health Sciences | N/A |
| Completed | Cerebral Oximetry in Lower Body Negative Pressure NCT03009305 | Oslo University Hospital | N/A |
| Completed | Study on Prediction of Fluid Responsiveness Using an Abdominal Compression-induced Change of Blood Pressure in NCT02471534 | Seoul National University Hospital | N/A |
| Terminated | Safety Study of Kedbumin 25% Versus Normal Saline in the Treatment of Post-Surgical Hypovolemia in Pediatric P NCT01531803 | Kedrion S.p.A. | Phase 4 |
| Completed | Influence of Variations of Systemic Venous Return on Analgesia Nociception Index (ANI) During General Anaesthe NCT02193412 | University Hospital, Lille | N/A |
| Completed | Comparison of Non-Invasive Methods of Assessing Fluid Responsiveness in ED and ICU Patients NCT02679625 | Olive View-UCLA Education & Research Institute | — |
| Unknown | Correlation Between ΔPP/HR and ΔSV During Fluid Challenge. NCT02439242 | University Hospital, Caen | — |
| Completed | The Importance of Albumin Infusion Rate for Plasma Volume Expansion Following Major Abdominal Surgery NCT02728921 | Region Skane | Phase 4 |
| Completed | Response of Pulse Pressure Variation in PA Catheter Tracing to IV Fluid Bolus in the ICU NCT02419404 | University of Virginia | — |
| Unknown | Central Venous and Abdominal Pressures and the Inferior Vena Cava NCT01840670 | Catholic University of the Sacred Heart | — |
| Completed | Observational Study of Oxygen Delivery During a Fractional Fluid Expansion NCT01826253 | University Hospital, Caen | — |
| Completed | Validation of Capnography as a Predictor of Cardiac Output Change as Measured by FloTrac NCT01880684 | Montreal Heart Institute | — |
| Completed | Preoperative Volume Substitution in Elective Surgery Patients NCT01811966 | Philipps University Marburg | N/A |
| Unknown | Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients W NCT01763853 | University Hospital, Clermont-Ferrand | Phase 4 |
| Unknown | Goal-directed Therapy in High-risk Surgery NCT01681238 | Guangzhou First People's Hospital | N/A |
| Unknown | Evaluation of Hemodynamics and Amount of Blood Flowing Through the Kidneys by Measuring Some Physiological Sub NCT01650103 | Azienda Ospedaliera di Padova | — |
| Completed | Comparison of Two Gelatine Solutions NCT01515397 | B. Braun Melsungen AG | Phase 3 |
| Completed | Comparison of Cardiac Output Measurement Between Transpulmonary Thermodilution and Photoplethysmography NCT01535703 | University Hospital, Caen | — |
| Completed | Detection of Hypovolemia Using Pleth Variability Index (PVI) NCT01456559 | University Hospital, Linkoeping | — |
| Completed | Detecting a Volume Deficit During Spontaneous Breathing NCT02549482 | Aalborg University Hospital | N/A |
| Completed | Predicting Volume Response Study NCT01656954 | University of Pennsylvania | — |
| Completed | Echocardiographic Assessment of Volume Variation Secondary to Preoperative Fasting NCT01258361 | Centre Hospitalier Universitaire de Nīmes | — |
| Completed | Trauma Heart to Arm Time NCT01210417 | Niguarda Hospital | — |
| Completed | Vasopressin in Traumatic Hemorrhagic Shock Study NCT00379522 | Volker Wenzel | Phase 2 / Phase 3 |
| Unknown | Neuroaxial Blokade and Blood Pressure NCT00435422 | Rigshospitalet, Denmark | N/A |
| Completed | Trial of 6% HES130/0.4 NCT01010022 | Fresenius Kabi Japan | Phase 3 |
| Terminated | Intraoperative Hypovolemia and Fluid Therapy NCT00852449 | University Hospital, Clermont-Ferrand | Phase 4 |
| Completed | Volume Deficit Prior to Surgery NCT00380107 | Rigshospitalet, Denmark | — |
| Completed | Comparison of Monitors of Fluid Therapy NCT00286338 | Rigshospitalet, Denmark | — |
| Unknown | Bedside Ultrasound Measurement of the Inferior Vena Cava Correlates to Central Venous Pressure NCT00596921 | Brooke Army Medical Center | — |