NCT07492511

Renal and Hepatic Abnormal Doppler Patterns in Trauma

Renal and hEpatiC abnoRmal dopplEr pAtterns iN Trauma: a Multicentre Prospective Observational Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 350 (estimated)
• Sponsor: Azienda Usl di Bologna · Other Government
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to learn about renal and hepatic blood flow abnormalities detected by bedside ultrasound in adult patients admitted to the intensive care unit (ICU) following major trauma. The main questions it aims to answer are: * How reliably can trained operators measure renal Doppler and venous congestion scores (RDRI and VExUS) across different hospitals? * How common are abnormal kidney and liver blood flow patterns in major trauma patients during the first 72 hours of ICU admission? * Are these abnormal patterns associated with acute kidney injury or the need for mechanical ventilation? Participants admitted to ICUs or high-dependency units (HDUs) with major trauma (Injury Severity Score \>15) will undergo non-invasive bedside ultrasound assessments at admission and at 24, 48, and 72 hours. No additional treatments or interventions will be given as part of this study. Kidney function will also be checked at 6 months after hospital discharge.

Conditions

• Trauma (Including Fractures)
• Trauma Patients
• Kidney Disease
• Hypovolemia
• Hypervolemia
• Kidney Failure

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Point of care ultrasound	Non-invasive bedside ultrasound assessment (renal Doppler and VExUS score) performed at baseline (≤6h from ICU admission), 24h, 48h, and 72h. No intervention is administered.

Timeline

• Start date: 2026-03-01
• Primary completion: 2029-12-31
• Completion: 2030-06-30
• First posted: 2026-03-25
• Last updated: 2026-03-25

Locations

1 site across 1 country: Italy