NCT05512611

Photoplethysmography for Diagnose Incipient Hypovolemia

Photopletysmography Detects Early Acute Blood Loss in Compensated Blood Donor Volunteers

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Hospital Privado de Comunidad de Mar del Plata · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Hypovolemia caused by acute bleeding increased morbi-mortality in emergency and operatin rooms. Precise real-time diagnosis of incipient acute hypovolemia is lacking at the bedside. We hypothesize that the infrared-red signals of pulse oximetry are sensitive to acute changes in patient's volemia. We aimed to test this hypothesis in a cohort of healthy blood donors as a model of simulated acute hypovolemia.

Detailed description

This is a prospective and observational study designed to determine if the changes observed in finger photoplethysmographic waveform can detect incipient hypovolemia. The investigators will studied 60 blood donor volunteers as a model of slight hypovolemia (8-10% of the volemia). Vital signs and photoplethysmography will be recorded in the thumb of the tested hand during a standard blood donation protocol. Recorded data will be analyzed and compared before and after blood donation .

Conditions

• Hypovolemia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Finger photoplethysmography	Finger photoplethysmography in tested hand, noninvasive blood pressure and heart rate during blood donation.

Timeline

• Start date: 2022-08-15
• Primary completion: 2023-02-28
• Completion: 2023-02-28
• First posted: 2022-08-23
• Last updated: 2023-03-01

Locations

1 site across 1 country: Argentina