| Not Yet Recruiting | FEAR of HYPOGLYCEMIA in PATIENTS WITH DIABETES NCT07329985 | Bilecik Seyh Edebali Universitesi | — |
| Recruiting | Monitoring Exhaled Breath to Noninvasively Detect Glycemic Events NCT06893341 | Indiana University | N/A |
| Recruiting | "Sexual Activity and Hypoglycemia Risk in Adults With Type 1 or Type 2 Diabetes Using Insulin Therapy and Cont NCT07286500 | Medical University of Warsaw | — |
| Recruiting | External Carotid Blood Flow in Individuals With Post-Bariatric Hypoglycemia NCT07082478 | Joslin Diabetes Center | — |
| Recruiting | A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 NCT06575426 | Otsuka Pharmaceutical Factory, Inc. | Phase 1 / Phase 2 |
| Enrolling By Invitation | Frequency of Hypoglycemia in Children With Beta-blocker Treated Long QT-syndrome NCT07233421 | Helsinki University Central Hospital | N/A |
| Active Not Recruiting | Glucagon Dose-Response in Patients With Post-Bariatric Hypoglycemia NCT06986603 | Joslin Diabetes Center | Phase 4 |
| Withdrawn | CGM/Clarity Use, Glycemic Control and Clinical Outcomes NCT03827434 | University of Maryland, Baltimore | N/A |
| Recruiting | Continuous Glucose Monitoring in HIE NCT06563687 | University of Campania Luigi Vanvitelli | N/A |
| Withdrawn | Diabetes Islet Preservation Immune Treatment NCT02586831 | Camillo Ricordi and Jay Skyler | Phase 1 / Phase 2 |
| Recruiting | Effect of C-peptide on Hypoglycemic Counterregulation NCT06470295 | University of Cincinnati | EARLY_Phase 1 |
| Completed | Study of a Primary Care Hypoglycemia Prevention Program NCT06353217 | Johns Hopkins University | N/A |
| Recruiting | Safer Aging With Diabetes Monitoring NCT06296485 | Kaiser Permanente | N/A |
| Completed | Postprandial Hypotension and Insulin Levels NCT06657287 | Ankara Yildirim Beyazıt University | — |
| Recruiting | Impact of MEnstruation on Glycemic Response and Exercise In Females With Type 1 Diabetes NCT06297980 | University of Colorado, Denver | N/A |
| Completed | Hypoglycemia Biomarkers to Predict Timing of a Hypoglycemic Event NCT06652867 | Royal College of Surgeons in Ireland - Medical University of Bahrain | — |
| Suspended | Concordance of Hypoglycemia Measurement With Simultaneous Use of Two Devices for Continuous Glucose Measuremen NCT06246578 | Central Jutland Regional Hospital | N/A |
| Completed | The Construction and Validation of a Risk Prediction Model for Perioperative Hypoglycemia in Digestive Endosco NCT07132476 | Ningbo No. 1 Hospital | — |
| Completed | Role of Adrenaline in in the Inflammatory Response in Diabetes NCT05990933 | Cees Tack | N/A |
| Recruiting | Continuous Subcutaneous Glucose Monitoring in Critical Patients NCT06234787 | Universidad Europea de Madrid | — |
| Recruiting | A Study of Glycemic Control in Left Ventricular Assist NCT05933161 | Mayo Clinic | — |
| Completed | Pilot Feasibility Study for HypoPals, a Mobile Health Program for Improving Hypoglycemia Management. NCT05916131 | University of Michigan | N/A |
| Unknown | Nurse Coaching the Effect of on Glycemic Control, Fear of Hypoglycemia and Risk Perception in Adults With Type NCT05870280 | Tuğba Bilgehan | N/A |
| Completed | Effects of a Health Intervention on Hypoglycemic Coping : a Pilot Study NCT06384118 | Yating Liu | N/A |
| Withdrawn | Slow Digestible Carbohydrates and Exercise in Adolescents With Type 1 Diabetes NCT05540132 | State University of New York at Buffalo | N/A |
| Recruiting | CGM-Assisted Management of PN NCT05902104 | Boston Children's Hospital | — |
| Recruiting | Enhancing Shared Decision-making to Guide Care for People With Dementia and Diabetes NCT05643144 | Indiana University | N/A |
| Completed | A Study to Inv. Safety, Efficacy & PD of Dasiglucagon as Hypoglycemia Rescue Therapy in Children <6 Years With NCT05378672 | Zealand Pharma | Phase 3 |
| Completed | Stimulated Glucagon as a Biomarker of Hypoglycemic Risk in Type 1 Diabetes NCT05616273 | University of Exeter | — |
| Completed | Continuous Glucose Monitoring for Hyperglycemia in Critically Ill Patients NCT05442853 | Malcom Randall VA Medical Center | N/A |
| Withdrawn | Micro Glucagon During Exercise in Type 1 Diabetes NCT04192019 | Insel Gruppe AG, University Hospital Bern | EARLY_Phase 1 |
| Unknown | Continuous Glucose Monitoring for Emergency Laparotomy NCT05641792 | Medical University of Gdansk | N/A |
| Completed | Continous Glucose Monitoring in Neonates at Risk of Hypoglycaemia- a Feasibility Study NCT07375615 | Sykehuset Innlandet HF | — |
| Completed | Investigating the Relationship Between Nocturnal Glucose Levels and Motion During Sleep NCT05609175 | University of Bern | — |
| Withdrawn | Efficacy and Safety of Dasiglucagon for Treatment of Post-bariatric Hypoglycemia in Roux-en-Y Gastric Bypass ( NCT04824872 | Zealand Pharma | Phase 2 |
| Recruiting | Endoscopic Ultrasound-guided Large Diameter Lumen-apposing Metal Stent Gastro-gastrostomy for Bypass Reversal NCT05640947 | University Hospital, Ghent | N/A |
| Completed | GLUCOSAFE 2 - A New Tool for Nutritional Management and Insulin-therapy in the Intensive Care Unit (ICU) NCT03890432 | HEIDEGGER CP | N/A |
| Unknown | Remote Glucose Monitoring in Hospital Settings NCT04797208 | Manchester University NHS Foundation Trust | N/A |
| Completed | The Effect of Physical Activity in Individuals With Post-bariatric Hypoglycemia NCT05560789 | Joslin Diabetes Center | N/A |
| Unknown | Galactose - the Ideal Carbohydrate Supplement for Exercise in Type 1 Diabetes NCT05557227 | University of Aarhus | N/A |
| Completed | Prehospital Provider Training With Augmented Reality (AR) NCT05686590 | Thomas Caruso | N/A |
| Completed | Neuronostatin - a Glucagonotropic Agent in Humans? NCT06143267 | University Hospital, Gentofte, Copenhagen | N/A |
| Completed | The HypoVoice Study NCT05569876 | Insel Gruppe AG, University Hospital Bern | N/A |
| Completed | Glucagon and Advanced HCL System to Prevent Exercise-Induced Hypoglycaemia in People With Type 1 Diabetes NCT05379686 | Steno Diabetes Center Copenhagen | N/A |
| Completed | The SHINE Study: Safety of Implant and Preliminary Performance of the SHINE SYSTEM in Diabetic Subjects NCT05597605 | Indigo Diabetes NV | N/A |
| Unknown | FreeStyle Libre 2 Discharge Trial NCT05822232 | Palo Alto Medical Foundation | N/A |
| Completed | The Effect of Glucose-dependent Insulinotropic Polypeptide on the Alpha Cell Response to Hypoglycaemia in Pati NCT06137586 | University Hospital, Gentofte, Copenhagen | N/A |
| Recruiting | Diabetes Clinical Decision Support NCT05447806 | Milton S. Hershey Medical Center | N/A |
| Unknown | Acute Changes in Plasma Glucose and Cardiovascular Disease in Diabetes NCT05500352 | Steno Diabetes Center Copenhagen | N/A |
| Completed | Continuous Glucose Monitoring (CGM) in Long Term Care (LTC) Facilities NCT05711108 | Joslin Diabetes Center | — |
| Completed | Low-dose Glucagon for Prevention of Exercise-Induced Hypoglycemia in People With Type 1 Diabetes NCT05076292 | Steno Diabetes Center Copenhagen | N/A |
| Unknown | Suspicion of Hypoglycemic Effect of mRNA Based Covid-19 Vaccines (Polyethylene Glycol) Will Happen , Observati NCT05087225 | Ministry of Health, Saudi Arabia | — |
| Completed | The Effectiveness of Multimedia Education on Hypoglycemic Management. NCT06516705 | Kaohsiung Medical University Chung-Ho Memorial Hospital | N/A |
| Unknown | Electronic Platform for Diabetic Patients Activation NCT04595383 | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana | N/A |
| Completed | The SMART B Exercise Study :''The SMART Study'' NCT05133765 | Steno Diabetes Center Copenhagen | N/A |
| Completed | The Effect of 'Medical Nutrition Therapy' on Post-bariatric Hypoglycemia 2-4 Years After Gastric Bypass Surger NCT05011682 | Helse Nord-Trøndelag HF | N/A |
| Completed | Maximising Time With a Normal Blood Glucose to Restore the Glucagon Response in Type 1 Diabetes NCT04614168 | University of Edinburgh | N/A |
| Completed | The Effect of Motivational Interviewing in Children With Type 1 Diabetes NCT06424574 | Yuzuncu Yil University | N/A |
| Completed | Analysis of Related Risk Factors of Hypoglycemia Consciousness Disorder NCT04971070 | Chongqing Renji Hospital, University of Chinese Academy of Sciences | — |
| Terminated | Effect of ZT-01 on Glucagon During Hypoglycemia in Type 1 Diabetes Mellitus NCT05007977 | Zucara Therapeutics Inc. | Phase 1 |
| Suspended | A Study to Improve Diabetes Management Among Adults Experiencing Severe Hypoglycemia NCT04874532 | Mayo Clinic | N/A |
| Active Not Recruiting | Cardiac Arrhythmia in Patients with End-Stage Renal Disease NCT04841304 | Rigshospitalet, Denmark | — |
| Completed | Pen-Administered Low-Dose Dasiglucagon for Prevention and Treatment of Hypoglycemia in People With Type 1 Diab NCT04764968 | Steno Diabetes Center Copenhagen | Phase 2 |
| Terminated | Continuous Glucose Monitoring Initiation at Hospital Discharge NCT04854135 | Washington University School of Medicine | N/A |
| Completed | Comparison of Ease of Use and Acceptability of Intranasal and Injectable Glucagon Among Providers Administerin NCT05395000 | CHU de Quebec-Universite Laval | N/A |
| Completed | EFFECTS OF MOXIFLOXACIN AND GEMIFLOXACIN ON BLOOD GLUCOSE AND ECG MORPHOLOGY OF EUGLYCEMICS:A CLINICAL STUDY NCT04692623 | Shaheed Benazir Bhutto University Sheringal Dir Upper | Phase 1 |
| Completed | CGM Use in Poorly Controlled Youth With Type 1 Diabetes NCT04721145 | Johns Hopkins University | N/A |
| Unknown | Diabetes Type One in Pregnancy and Continuos Glucose Monitoring NCT04997460 | Clinical Hospital Centre Zagreb | — |
| Completed | Reducing Treatment Risk in Older Adults With Diabetes NCT04585191 | Kaiser Permanente | N/A |
| Completed | Hypo-METRICS: Hypoglycaemia - Measurement, ThResholds and ImpaCtS NCT04304963 | King's College London | — |
| Recruiting | DiGESTnewborn Study NCT04192422 | Cambridge University Hospitals NHS Foundation Trust | — |
| Completed | Impact of Glycemic Control After Reperfusion on Acute Kidney Injury in Living Donor Liver Transplantation NCT06320730 | Asan Medical Center | — |
| Completed | Evaluating Glial Acetate Metabolism as a Biomarker of Hypoglycemic Complications in Diabetic Patients NCT04430660 | Pennington Biomedical Research Center | N/A |
| Completed | Glycemic Control Before, During and After the 2016 Paris Marathon NCT04926298 | University Hospital, Brest | — |
| Active Not Recruiting | Mechanisms of Hypoglycemia in Patients Without Diabetes NCT04428723 | Joslin Diabetes Center | — |
| Completed | Cognition in Patients With Hypoglycemia, Without Diabetes NCT04430582 | Joslin Diabetes Center | — |
| Completed | Assessing Insulin Turnover Using an In-vivo Deuterated Water Experiment. NCT04332289 | Lia Bally | — |
| Completed | Low-dose Dasiglucagon for Prevention of Insulin-Induced Hypoglycemia in People With Type 1 Diabetes NCT04449692 | Steno Diabetes Center Copenhagen | Phase 2 |
| Completed | Wireless Assessment of Respiratory and Circulatory Distress - Continuous Glucose Monitoring NCT04473001 | University Hospital Bispebjerg and Frederiksberg | — |
| Recruiting | French National Cohort of People With Type 1 Diabetes NCT04657783 | Fondation Francophone pour la Recherche sur le Diabete | — |
| Terminated | Effects of a Hypoglycemia Protocol With Glucose Gel on Neonatal Intensive Care Unit (NICU) Admission NCT04085978 | Pediatrix | — |
| Unknown | Mechanisms of Post-Bariatric Hypoglycemia NCT04428866 | Joslin Diabetes Center | — |
| Completed | A Study of Tirzepatide in Participants With Type 2 Diabetes Mellitus NCT04050553 | Eli Lilly and Company | Phase 1 |
| Recruiting | Evaluating Glial Acetate Metabolism as a Biomarker of Hypoglycemic Counterregulation NCT04207619 | Pennington Biomedical Research Center | N/A |
| Completed | Investigating Novel Predictions of Hypoglycemia Occurrence in Real-world Models NCT04219514 | Stewart Harris | — |
| Unknown | Continuous Glucose Monitoring (CGM) After Surgical Variations of the Roux-en-y Gastric Bypass NCT04172116 | Medical University of Vienna | — |
| Completed | Hypoglycemia and Glucagon Response in CF NCT05700604 | Marmara University | — |
| Recruiting | Effect of Fasting on Hypoglycemic Counterregulation in Type 1 Diabetes NCT05973799 | University of Cincinnati | N/A |
| Completed | The Functional Neuroanatomy of the Human Physiological Stress Response NCT03867344 | Brigham and Women's Hospital | N/A |
| Terminated | Insulin Tolerance Test Study in Patients With Type 1 Diabetes NCT04026750 | High Point Clinical Trials Center | Phase 1 |
| Completed | 24/7 Closed-loop in Older Subjects With Type 1 Diabetes NCT04025762 | University of Cambridge | N/A |
| Withdrawn | Introducing CGM at Type 1 Diabetes Diagnosis NCT03736083 | University of Florida | N/A |
| Completed | Glucagon Ready-to-Use (RTU) for Prevention of Exercise-Induced Hypoglycemia During Aerobic Exercise in Adults NCT03841526 | Xeris Pharmaceuticals | Phase 2 |
| Completed | Consequences of Hypoglycaemia on Cardiovascular and Inflammatory Responses NCT03976271 | Radboud University Medical Center | N/A |
| Completed | Dual-hormone Closed-loop Glucose Control in Type 1 Diabetes NCT04053712 | Steno Diabetes Center Copenhagen | Phase 4 |
| Unknown | Prevention of Hypoglycemia Among Diabetes Patients Admitted to Internal Medicine Departments With Nutritional NCT03802942 | Eyal Leibovitz | Phase 3 |
| Completed | The Role of Glucose-Dependent Insulinotropic Polypeptide in the Pathological Glucose Homeostasis Of Type 1 Dia NCT03734718 | Steno Diabetes Center Copenhagen | N/A |
| Completed | Effect of Fasting on Insulin-induced Hypoglycemia Counterregulation in Healthy Humans NCT04392843 | University of Cincinnati | N/A |
| Completed | Exercise-Induced Hypoglycemia Prevention in Adults With Type 1 Diabetes Using an Artificial Pancreas NCT03859401 | Marc Breton | N/A |
| Completed | A Trial to Compare the Efficacy and Safety of 2 Different Batches of Subcutaneous Dasiglucagon in Patients Wit NCT03895697 | Zealand Pharma | Phase 3 |
| Completed | Continuous Glucose Monitoring to Reduce Hypoglycemia and Improve Safety After Gastric Surgery NCT03353415 | Joslin Diabetes Center | N/A |
| Active Not Recruiting | Hypoglycemia and the Gut Microbiome NCT03385707 | Joslin Diabetes Center | — |
| Completed | The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism NCT03868657 | Signe Torekov | N/A |
| Terminated | Novel Approach for the Prevention of Hypoglycemia Associated Autonomic Failure (HAAF) NCT03608163 | Albert Einstein College of Medicine | Phase 4 |
| Terminated | Assessment of the Impact of Real-Time Continuous Glucose Monitoring on People Presenting With Severe Hypoglyca NCT03748433 | Imperial College London | N/A |
| Completed | Hypoglycemia and Cardiac Arrhythmias in Type 1 Diabetes NCT03956173 | Steno Diabetes Center Copenhagen | — |
| Completed | Effect of Dapagliflozin on IAH in T1DM NCT03556033 | Radboud University Medical Center | Phase 2 |
| Completed | Evaluation of the Safety, Tolerability and Bioavailability of Dasiglucagon Following Subcutaneous (SC) Compare NCT03735225 | Zealand Pharma | Phase 1 |
| Completed | Trial to Confirm the Clinical Efficacy and Safety of Dasiglucagon in the Treatment of Hypoglycemia in Subjects NCT03688711 | Zealand Pharma | Phase 3 |
| Completed | Correlation Between Exercise and Insulin Dose in a Camp for Pediatric Type 1 Patients NCT03725657 | University of Campania Luigi Vanvitelli | — |
| Completed | Prediction and Prevention of Nocturnal Hypoglycemia in Persons With Type 1 Diabetes Using Machine Learning Tec NCT03711656 | Hospital Clinic of Barcelona | N/A |
| Completed | Prevention Through Intervention: Telehealth Solution to Deter 911 Calls Due to Hypoglycemia NCT03665870 | University of Alabama at Birmingham | N/A |
| Completed | Role of CGMS Usage in Predicting Risk for Hypoglycemia NCT03481530 | University of Minnesota | — |
| Unknown | Antenatal Betamethasone and the Risk of Neonatal Hypoglycemia NCT03702959 | Rambam Health Care Campus | — |
| Completed | Trial to Confirm the Efficacy and Safety of Dasiglucagon in the Treatment of Hypoglycemia in T1DM Children NCT03667053 | Zealand Pharma | Phase 3 |
| Completed | Pilot Study of OMEGA-3 and Vitamin D in High-Dose in Type I Diabetic Patients NCT03406897 | Rodolfo Alejandro | Phase 1 / Phase 2 |
| Active Not Recruiting | Continuous Glucose Monitoring Devices in Hospitalized Veterans With Diabetes NCT03508934 | VA Office of Research and Development | N/A |
| Completed | Telemedicine Monitoring of Nocturnal Incidents NCT04328896 | University of Southern California | N/A |
| Unknown | Diabetes and Cognitive Functions in Middle Age NCT05919927 | Tampere University Hospital | — |
| Completed | Lipohypertrophy Monitoring Study NCT04659330 | University Hospital, Antwerp | N/A |
| Completed | Biomarkers in Exhaled Breath of Glucose Fluctuation in Type 1 Diabetes NCT03435198 | East Tennessee State University | — |
| Unknown | A Combined Biofeedback-virtual Reality System for Reduction of Fear of Hypoglycemia NCT02380339 | Hadassah Medical Organization | N/A |
| Completed | Impact of Hypoglycaemia in Patients With Diabetes Mellitus Type 2 on Platelet Activation NCT03460899 | Medical University of Graz | N/A |
| Completed | A Trial to Confirm the Efficacy and Safety of Dasiglucagon in the Treatment of Hypoglycemia in Type 1 Diabetes NCT03378635 | Zealand Pharma | Phase 3 |
| Terminated | Frequency of Hypoglycemia in Patients With Type 2 Diabetes Under Insulin Therapy Older Than 75 Years in Real L NCT03020264 | Nantes University Hospital | N/A |
| Completed | A Study of Nasal Glucagon in Participants With Type 1 Diabetes Mellitus NCT03339453 | Eli Lilly and Company | Phase 1 |
| Completed | Hypoglycemia and Autonomic Nervous System Function- B2 NCT03422471 | Brigham and Women's Hospital | N/A |
| Completed | Hybrid Closed Loop Insulin Delivery System in Hypoglycemia NCT03215914 | University of Pennsylvania | N/A |
| Completed | A Trial to Evaluate the Immunogenicity of Dasiglucagon and GlucaGen in Patients With Type 1 Diabetes Mellitus NCT03216226 | Zealand Pharma | Phase 3 |
| Completed | FreeStyle Libre FGM During Summer Camp for Children With Type 1 Diabetes NCT03182842 | University of Ljubljana, Faculty of Medicine | N/A |
| Completed | Effects of Mild Hypoglycaemia on Cognitive Function in Type 2 Diabetes NCT03014011 | Bispebjerg Hospital | N/A |
| Completed | Exercise Physiology Study NCT03090451 | Oregon Health and Science University | N/A |
| Completed | Insulin Management for Exercise in Patients With Type 1 Diabetes NCT03130101 | York University | N/A |
| Completed | Technological Advances in Glucose Management in Older Adults NCT03078491 | Joslin Diabetes Center | N/A |
| Terminated | Quantitative Assessment of Sucking for Early Diagnosis of Brain Injury in Infants at High Risk NCT03246243 | Boston Children's Hospital | — |
| Completed | Safety and Efficacy of G-Pen Compared to Lilly Glucagon for Hypoglycemia Rescue in Adult Type 1 Diabetics NCT02656069 | Xeris Pharmaceuticals | Phase 3 |
| Completed | Hypoglycaemia Awareness Restoration Programme NCT02940873 | King's College London | N/A |
| Completed | Comparison Between Hypoglycemic Counter Regulatory Responses in Type 1 Diabetics vs Control Subjects NCT03034226 | University of Aarhus | N/A |
| Completed | Exenatide and Impaired Hypoglycaemic Awareness in Type 1 Diabetes NCT02735031 | Radboud University Medical Center | Phase 2 / Phase 3 |
| Active Not Recruiting | Adrenergic System in Islet Transplantation NCT03079921 | University of Pennsylvania | EARLY_Phase 1 |
| Completed | Hypoglycemia Prediction Model NCT03006510 | University of California, San Francisco | N/A |
| Completed | Identifying the Brain Substrates of Hypoglycemia Unawareness in Type 1 Diabetes NCT02866435 | University of Minnesota | EARLY_Phase 1 |
| Completed | Malglycemia in the Pediatric Hematopoietic Stem Cell Transplant Population NCT03482154 | University of Colorado, Denver | — |
| Unknown | Dose Response Oxidation of a Sweet-corn Derived Sugar (PhytoSpherix) During Exercise in Endurance Trained Athl NCT02909881 | University of Western Ontario, Canada | N/A |
| Completed | Post Bariatric Closed Loop Glucagon Trial NCT02966275 | Massachusetts General Hospital | N/A |
| Completed | The Late Effects of Ethanol Intake on the Glucose Response to Subcutaneous Glucagon in Type 1 Diabetes NCT02881060 | Hvidovre University Hospital | Phase 4 |
| Completed | Dextrose Gel Does Not Prevent Neonatal Hypoglycemia NCT02523222 | Baylor College of Medicine | Phase 2 / Phase 3 |
| Terminated | T1 Diabetes Hypoglycemia Prevention Pilot NCT02682940 | InSpark Technologies, Inc. | N/A |
| Completed | Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms, Pump Suspension NCT02714972 | Jaeb Center for Health Research | Phase 2 |
| Terminated | A Pilot Study of Nocturnal Hypoglycemia Prevention in Type 1 Diabetes Using the Vigilant Diabetes Management C NCT02906891 | InSpark Technologies, Inc. | N/A |
| Unknown | GLP1R-imaging in Hypoglycemia NCT03182192 | Radboud University Medical Center | Phase 1 |
| Completed | An Open-Label Study of XOMA 358 in Patients With Hypoglycemia After Gastric Bypass Surgery NCT02772718 | XOMA (US) LLC | Phase 2 |
| Completed | Continuous Glucose Monitoring in New Mothers With Type 1 Diabetes NCT02898428 | Steno Diabetes Center Copenhagen | — |
| Completed | Delivery of G-Pump™ (Glucagon Infusion) From an OmniPod® to Prevent Hypoglycemia in Post-Bariatric Surgery Pat NCT02733588 | Xeris Pharmaceuticals | Phase 2 |
| Completed | Effect of Hypoglycemia on Sleep NCT02687893 | Oregon Health and Science University | N/A |
| Completed | Testing Glial Pathways to HAAF in Human Subjects Using Carbon 13 Magnetic Resonance Spectroscopy NCT02690168 | Pennington Biomedical Research Center | — |
| Completed | Primary Care Clinicians' Responses to a Hypoglycemia Risk Calculator for Diabetes Mellitus in Ambulatory Care NCT04177147 | Indiana University | N/A |
| Completed | Single Doses of ZP4207 Adm. sc to Hypoglycemic TD1 pt. to Describe the PK and PD of ZP4207 as Comp. to Markete NCT02660008 | Zealand Pharma | Phase 2 |
| Completed | Simplification of Complex Insulin Regimens With Preserving Good Glycemic Control in Type 2 Diabetes NCT04020445 | Bekes County Central Hospital | — |
| Completed | Outcomes Study of MTM in a Medicare ACO NCT02875925 | HealthEast Care System | N/A |
| Completed | Treatment of Hypoglycemia Following Gastric Bypass Surgery NCT02527993 | Zealand University Hospital | Phase 4 |
| Completed | Glucagon Efficiency After High and Low Carbohydrate Diet NCT02578498 | Hvidovre University Hospital | Phase 4 |
| Withdrawn | How to be Safe With Alcoholic Drinks in Diabetes NCT02518022 | Kinderkrankenhaus auf der Bult | N/A |
| Recruiting | Differing Levels of Hypoglycemia NCT02445781 | University of Maryland, Baltimore | EARLY_Phase 1 |
| Completed | Multiple Ascending Doses of ZP4207 Administered to HV to Evaluate the Safety, Tolerability, PKs and PDs of ZP4 NCT02390141 | Zealand Pharma | Phase 1 |
| Completed | G-Pen™ for Hypoglycemia Rescue in T1D Patients NCT02423980 | Xeris Pharmaceuticals | Phase 2 |
| Completed | Clinical Usability of Nasal Glucagon in Treatment of Hypoglycemia in Children and Adolescents NCT02402933 | Eli Lilly and Company | Phase 3 |
| Completed | Hypoglycemia (Low Blood Sugar) and the Heart NCT01980914 | University of British Columbia | N/A |
| Terminated | Efficacy of Continuous Glucose Monitoring in Neonates With Hypoglycemia NCT02300285 | Boston Children's Hospital | N/A |
| Completed | Suspending Basal Insulin Levels for Exercise in Adults With Type 1 Diabetes NCT03034798 | York University | — |
| Completed | Safety and Efficacy of ZP-Glucagon to Injectable Glucagon for Hypoglycemia NCT02459938 | Zosano Pharma Corporation | Phase 1 |
| Completed | Multi-Center Study Comparing Efficacy and Safety of Frequently Modified Insulin Therapy NCT02424500 | Hygieia Research LLC | N/A |
| Completed | Single Ascending Doses of ZP4207 Administered in HV and in T1D to Evaluate Safety, Tolerability PKs and PDs of NCT02367053 | Zealand Pharma | Phase 1 |
| Completed | Pharmacokinetics and Pharmacodynamics of BIOD-961 vs. Marketed Glucagons NCT02403648 | Biodel | Phase 1 |
| Completed | Allogeneic Islet Cells Transplanted Onto the Omentum NCT02213003 | Rodolfo Alejandro | Phase 1 / Phase 2 |
| Completed | Hypoglycemia in Hospitalized Patients NCT02228642 | University of Pittsburgh | — |
| Completed | Comparison of the Effect of a Novel Starch (Glycosade) Versus Gastrostomy Tube-Dextrose Infusion on Overnight NCT02176096 | University of Manitoba | N/A |
| Completed | Clinical Usability of Intranasal Glucagon in Treatment of Hypoglycemia NCT02171130 | Eli Lilly and Company | Phase 3 |
| Completed | Safety and Efficacy Study of Mini-Dose Glucagon (G-Pen Mini) in Patients With Type 1 Diabetes NCT02081014 | Xeris Pharmaceuticals | Phase 2 |
| Completed | PK/PD Study With G-Pump (Glucagon Infusion) in T1DM Patients NCT02081001 | Xeris Pharmaceuticals | Phase 2 |
| Completed | Impact of Physical Activity on Blood Glucose Stability and Energy Stores in Individuals With Type 1 Diabetes NCT02068638 | Insel Gruppe AG, University Hospital Bern | N/A |
| Terminated | CREON for the Treatment of Post-RYGB Hypoglycemia NCT02733848 | East Carolina University | Phase 1 |
| Terminated | Role of GLP-1 in Hyperinsulinemic Hypoglycemia Post-bariatric Surgery NCT02550145 | Tracey McLaughlin | Phase 1 |
| Completed | Multicentre LOGIC-Insulin Algorithm-guided Versus Nurse-directed Blood Glucose Control During Critical Illness NCT02056353 | KU Leuven | N/A |
| Completed | Glycemic Excursions in Type 2 Diabetic Patients With Vildagliptin and Metformin Versus Vildagliptin and Glimep NCT02007278 | Novartis Pharmaceuticals | Phase 4 |
| Completed | Insulin Dosing in Diabetic Patients With End Stage Renal Disease (ESRD) or Hemodialysis NCT02083133 | Cook County Health | — |
| Completed | Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) Study of G-Pen(TM) (Glucagon Injection) to NCT01972152 | Xeris Pharmaceuticals | Phase 2 |
| Completed | Intracellular Counter-regulatory Mechanisms Following Low Blood Glucose NCT01919788 | University of Aarhus | N/A |
| Completed | Hypoglycemia and Autonomic Nervous System Function-B NCT03429946 | Brigham and Women's Hospital | Phase 4 |
| Completed | Hypoglycemia in Prader-Willi Syndrome NCT01897363 | University of Florida | — |
| Completed | Etiology, Assessment and Treatment of Post-gastric Bypass Severe Hypoglycemia NCT01865760 | University of Aarhus | N/A |
| Completed | Brain Ketone Metabolism in Type 1 Diabetes NCT02471040 | Yale University | Phase 1 |
| Completed | Hippocampal Metabolism and Function in Patients With Type 1 Diabetes NCT01852968 | University of Minnesota | — |
| Completed | Bioequivalence of Fresenius Kabi USA, LLC Glucagon for SC Injection Compared to Glucagon for Injection (Bedfor NCT02086227 | Fresenius Kabi USA, LLC | Phase 1 |
| Completed | The Effect of Glucomannan Soluble Fiber on Glucose Homeostasis in Patients With Roux En Y (RNY) Gastric Bypass NCT02336438 | Bassett Healthcare | Phase 4 |
| Terminated | Monitoring Glucose Levels in Patients With Myocardial Infarction NCT03107806 | Lars Ryden | N/A |
| Completed | Hypoglycemia Requiring Emergency Services Intervention: Patient Characteristics, Outcome and Cardiovascular Ri NCT04422145 | University of Leeds | N/A |
| Completed | Hypoglycaemia in People With Type 2 Diabetes in Primary Care NCT02666521 | University of Leicester | — |
| Completed | GIP and GLP-1 in Type 1 Diabetes NCT01739283 | Mikkel Christensen | N/A |
| Completed | Safety and Efficacy of a Novel Glucagon Formulation in Type 1 Diabetic Patients Following Insulin-induced Hypo NCT01556594 | Eli Lilly and Company | Phase 2 |
| Unknown | Affect of RT-CGMS as Part of Clinical Care in Type 1 Diabetes Mellitus Patients NCT01525784 | Assaf-Harofeh Medical Center | — |
| Completed | Identifying Driving Risk Factors in Type 1 Diabetes and Their Reduction Via Internet Program (DiabetesDriving. NCT01563887 | University of Virginia | N/A |
| Completed | Acute Maternal and Fetal Effects of Exercise in Pregnancy NCT01383889 | Instituto Materno Infantil Prof. Fernando Figueira | N/A |
| Completed | Effect of Different Plasma Insulin Levels on the Accuracy of Continuous Subcutaneous Glucose Monitoring NCT01714895 | Fundación para la Investigación del Hospital Clínico de Valencia | N/A |
| Completed | Effect of Naltrexone on Counterregulatory Mechanisms in Hypoglycemia NCT01462227 | Yale University | N/A |
| Withdrawn | Lactate to Treat Hypoglycemia NCT01387477 | Institut d'Anesthesiologie des Alpes Maritimes | Phase 4 |
| Completed | Evaluation of the Effect of Hypoglycemia With PET and a Norepinephrine Transporter Ligand NCT02056249 | Yale University | — |
| Completed | Dipeptidyl Peptidase-4 Inhibitors and Alpha-cell Recovery NCT01272583 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Completed | Maternal Lifestyle and Neonatal Hypoglycemia NCT01409382 | Hospital dos Servidores do Estado do Rio de Janeiro | N/A |
| Unknown | Pilot Study of Intensive Care Unit Continuous Glucose Monitoring NCT01301053 | University of Virginia | N/A |
| Completed | Blood/Interstitial Glucose Measurements and Cognitive Function During Hypoglycemia and Recovery NCT01283126 | Joslin Diabetes Center | N/A |
| Completed | Hypoglycemia and the Mineralocorticoid Receptor NCT01394627 | Brigham and Women's Hospital | N/A |
| Terminated | Evaluation of Hypo-Safe Hypoglycaemia Alarm Device - a Pilot Study NCT01238016 | UNEEG Medical A/S | N/A |
| Completed | Hypoglycemia: Physician and Patient Perspectives NCT01176656 | AstraZeneca | — |
| Completed | Vildagliptin and the Glucagon Response to Hypoglycemia in Type 1 Diabetes NCT01147276 | Lund University | Phase 4 |
| Completed | Cognitive Function and Electrocardiogram (ECG) During Hypoglycemia and Blockade of the Renin-angiotensin Syste NCT01116180 | Louise Faerch | N/A |
| Completed | Pramlintide (Symlin) for the Treatment of Hypoglycemia Following Gastric Bypass Surgery NCT01841359 | Joslin Diabetes Center | Phase 4 |
| Completed | Identification of Inpatients at Risk for Poor Glycemic Control NCT01043042 | Vanderbilt University Medical Center | — |
| Recruiting | Role of Neural and Hormonal Regulation Factors on Insulin Secretion After Gastric Bypass Surgery NCT00992901 | The University of Texas Health Science Center at San Antonio | EARLY_Phase 1 |
| Unknown | Diazoxide In the Management Of Hypoglycemic Neonates NCT00994149 | University of Saskatchewan | Phase 2 / Phase 3 |
| Completed | Comparison Between Pyloric Preserving and Non-Pyloric Preserving Bariatric Surgery With Glucose Challenge NCT00998374 | Medtronic - MITG | — |
| Terminated | Glycemic Effects of Morning Only, Evening Only or Twice Daily Insulin Glargine in Patients With Type 1 Diabete NCT00869414 | Johns Hopkins University | N/A |
| Completed | Intravenous Exenatide (Byetta) During Surgery NCT00882050 | Thomas Jefferson University | Phase 1 / Phase 2 |
| Completed | Associated Factors in Perioperative Hypoglycemia in Patients With Diabetes NCT00826007 | Corewell Health East | — |
| Completed | Idiopathic Reactive Hypoglycaemia and Treatment With Fructo-Oligosaccharide NCT00802971 | Asker & Baerum Hospital | N/A |
| Terminated | The Efficacy of Glucagon Like Peptide (GLP) - 1(7-36) Amide for Glycemic Control in Critically Ill Patients NCT00798590 | Johns Hopkins University | Phase 2 |
| Completed | GLP 1 for Intraoperative Glycemic Control NCT00882492 | University of Pennsylvania | Phase 1 |
| Completed | Investigating the Accuracy of the Home Glucose Monitors in Hypoglycemia NCT01013402 | Gulhane School of Medicine | Phase 4 |
| Completed | Real-time Continuous Glucose Monitoring in Very Low Birth Weight Neonates NCT01942239 | University Hospital, Tours | N/A |
| Completed | International Navigator Hypoglycaemia Study NCT00843609 | University Medical Centre Ljubljana | N/A |
| Terminated | Tight Glycaemic Control During Cardiac Surgery NCT01225159 | Prince of Songkla University | N/A |
| Terminated | Sitagliptin Versus Sulphonylurea in Type 2 Diabetes During Ramadan NCT00766441 | University of Manchester | Phase 4 |
| Completed | Treatment With Erythropoietin and Cognition During Hypoglycaemia NCT00615368 | Hillerod Hospital, Denmark | N/A |
| Unknown | Mechanisms of Hypoglycemia Associated Autonomic Failure NCT00678145 | Albert Einstein College of Medicine | Phase 2 |
| Completed | Computer Decision Support to Achieve Glycemic Control in the ICU NCT00589589 | United States Army Institute of Surgical Research | Phase 1 |
| Unknown | Inpatient Self Monitoring and Administration Study (ISMAS) NCT00506272 | Atlanta VA Medical Center | N/A |
| Completed | Glucagon in the Treatment of Hypoglycemia in Newborn Infants of Diabetic Mothers NCT00434772 | Shaare Zedek Medical Center | Phase 2 |
| Unknown | Observational Study of Infants Born at 34 to 37 Weeks of Gestation Until the Age of 1 Year NCT00550069 | Sheba Medical Center | — |
| Terminated | Raptiva and Sirolimus in Islet Transplantation for Type 1 Diabetes NCT00672204 | University of Minnesota | Phase 1 / Phase 2 |
| Completed | Whole Body 111In-exendin-4 Imaging Study in Insulinoma Patients NCT00937079 | University Hospital, Basel, Switzerland | — |
| Completed | Pharmacokinetics (PK) and Pharmacodynamics (PD) of Mayne Glucagon for Injection Compared With Glucagen® (Novo NCT00745186 | Hospira, now a wholly owned subsidiary of Pfizer | Phase 1 |
| Completed | Influence of Dietary Fiber-rich Meals on Gene Expression and Postprandial Glucose and Lipid Response NCT01005342 | Lund University | N/A |
| Completed | Effect of Continuous Glucose Monitoring on Course of Glucose in Type 1 Diabetes NCT00467688 | Forschungsinstitut der Diabetes Akademie Mergentheim | N/A |
| Completed | EEG-Changes During Insulininduced Hypoglycemia in Type 1 Diabetes NCT00810420 | UNEEG Medical A/S | — |
| Withdrawn | Effects of Pulsatile Intravenous Insulin Delivery on Hypoglycemic Unawareness NCT01029639 | Florida Atlantic University | Phase 2 / Phase 3 |
| Completed | Bedtime Insulins and Oral Antihyperglycemic Drugs in Type 2 Diabetes NCT00641407 | University of Campania Luigi Vanvitelli | Phase 4 |
| Completed | Using Glucose Sensors to Prevent Hypoglycemia NCT00554281 | University of Alberta | Phase 3 |
| Completed | Phase 1 Study of BHT-3021 in Subjects With Type 1 Diabetes Mellitus NCT00453375 | Bayhill Therapeutics | Phase 1 |
| Completed | Adrenaline Injections to Children Born at Elective CS NCT00322660 | Hvidovre University Hospital | N/A |
| Terminated | Hypoglycemia Counterregulation and Symptom Perception With Insulin Detemir NCT00490893 | University Hospital Tuebingen | Phase 4 |
| Withdrawn | Blood Sugars in Children With Idiopathic Seizures. NCT00279851 | Children's Mercy Hospital Kansas City | — |
| Completed | The Impact of Renin-angiotensin System on Brain Activation During Hypoglycaemia in Healthy Men, a PET Study NCT00264641 | Hypoglycaemia Research Group | N/A |
| Completed | MGA031, Sirolimus and Tacrolimus in Islet Transplantation NCT00265473 | University of Minnesota | Phase 1 / Phase 2 |
| Completed | Study of How Low Blood Sugar Affects the Way Blood Vessels Work NCT00373854 | Ohio State University | — |
| Completed | Impact of Hypoglycemia Unawareness on Brain Metabolism Cognition in T1DM NCT00575783 | Yale University | — |
| Completed | Octreotide for the Treatment of Sulfonylurea-Associated Hypoglycemia NCT00804297 | Albert Einstein Healthcare Network | Phase 3 |
| Completed | NAET® Testing Devices in Detection of Hypersensitivity to Cane Sugar NCT00292578 | Nambudripad's Allergy Research Foundation | Phase 1 / Phase 2 |
| Completed | Carnitine Levels and Carnitine Supplementation in Type I Diabetes NCT00351234 | Children's Mercy Hospital Kansas City | — |
| Completed | Hypoglycemia and Autonomic Nervous System Function NCT01816893 | Brigham and Women's Hospital | N/A |
| Completed | Skittles(TM) Effective for Treating Hypoglycemia in Children With Type 1 Diabetes NCT00706693 | University of Calgary | N/A |
| Completed | Islet Allotransplantation With Steroid Free Immunosuppression NCT00446264 | University Hospital, Lille | Phase 2 |
| Completed | Anti-Thymocyte Globulin, Cyclosporine, and RAD in Islet Transplantation NCT00286624 | University of Minnesota | Phase 1 / Phase 2 |
| Completed | Late Night Snack and Insulin Glargine NCT02871180 | Diabeteszentrum Bad Lauterberg im Harz | N/A |
| Completed | Investigation Into the Effects Upon Brain Response to Change in Circulating Glucose Levels in Diabetes Mellitu NCT00580710 | Yale University | — |
| Completed | Delayed Mycophenolate Mofetil in Single-Donor Islet Allotransplantation in Type 1 Diabetes NCT00285233 | University of Minnesota | Phase 1 / Phase 2 |
| Completed | hOKT3γ1 (Ala-Ala) Combined With Sirolimus and Delayed Tacrolimus in Type 1 Diabetic Islet Allograft Recipients NCT00285194 | University of Minnesota | Phase 1 / Phase 2 |
| Recruiting | Diagnosing and Treating Low Blood Sugar Levels NCT00001276 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | — |
| Completed | Disorders of Systemic Glucose Balance NCT00006508 | National Center for Research Resources (NCRR) | N/A |
| No Longer Available | Islet Transplant for Type 1 or Surgical Diabetes NCT01606475 | University of Minnesota | — |