| Not Yet Recruiting | A Randomized Trial of Botulinum Toxin A vs Strabismus Surgery for Esotropia >10 to ≤30PD Esotropia | Phase 3 | 2027-01-01 |
| Not Yet Recruiting | Omega-3 Supplementation vs Demodex vs Eyelid Cleanser for Pediatric Chalazia Pediatric Chalazia | Phase 2 | 2026-06-01 |
| Not Yet Recruiting | Longitudinal Natural History Study of Retinal Function in Eyes of Patients With Diabetes Diabetic Retinal Disease | — | 2026-05-02 |
| Not Yet Recruiting | A RCT of Spectacles With Aspherical Lenslets or 0.05% Atropine for Myopia Control Myopia | Phase 3 | 2026-05-01 |
| Not Yet Recruiting | A Study of Uveitis in Children <18 Years of Age Uveitis | — | 2026-04-01 |
| Recruiting | Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM) Cystic Fibrosis (CF), Cystic Fibrosis-related Diabetes, Diabetes | — | 2025-09-18 |
| Withdrawn | Bifocal Spectacles vs. Single Vision Spectacles for Esotropia Greater at Near Esotropia | Phase 3 | 2025-09-01 |
| Recruiting | Faricimab + PRP vs. Vitrectomy + Endolaser for Treatment of PDR Proliferative Diabetic Retinopathy (PDR) | Phase 3 | 2025-08-04 |
| Recruiting | Effect of Inhaled Technosphere Insulin vs RAA Insulin on Exercise-Induced Hypoglycemia in Adults With T1D Usin Diabetes Mellitus, Type 1 | N/A | 2025-06-05 |
| Recruiting | CGM for the Early Detection and Management of Hyperglycemia in Pregnancy Gestational Diabetes Mellitus in Pregnancy | N/A | 2025-05-27 |
| Recruiting | Inhaled Insulin vs Rapid-acting Injections for Post-meal Glucose Control in Women With Gestational Diabetes Diabetes, Gestational, Pregnancy Complications, Glucose Metabolism Disorders | Phase 2 / Phase 3 | 2025-05-01 |
| Recruiting | T1D Pregnancy & Me Diabetes Mellitus, Type 1, Pregnancy in Diabetics, Pregnancy, High-Risk | — | 2025-04-25 |
| Recruiting | Dichoptic Treatment for Amblyopia in Children 8 to 12 Years of Age Amblyopia | Phase 3 | 2024-10-22 |
| Recruiting | Bionic Pancreas in CFRD Cystic Fibrosis-related Diabetes | Phase 3 | 2024-09-24 |
| Recruiting | Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age Amblyopia | Phase 3 | 2024-07-01 |
| Active Not Recruiting | Gyrate Atrophy Ocular and Systemic Study Gyrate Atrophy, Gyrata of Choroid and Retina; Atrophy, Ornithine-δ-aminotransferase | — | 2023-11-21 |
| Recruiting | Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Radiation Retinopathy, Visual Impairment | Phase 3 | 2023-11-21 |
| Recruiting | Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD Neovascular Age-related Macular Degeneration | Phase 3 | 2023-11-09 |
| Completed | Loop T2D Observational Study Diabetes Mellitus, Type 2 | — | 2023-06-20 |
| Recruiting | Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Di Inherited Retinal Degeneration, Retinitis Pigmentosa | — | 2023-05-11 |
| Active Not Recruiting | Evaluation of Tonabersat for DME Diabetic Macular Edema | Phase 2 | 2023-05-02 |
| Active Not Recruiting | Strength and Muscle Related Outcomes for Nutrition and Lung Function in CF Cystic Fibrosis | — | 2023-04-20 |
| Completed | Full-Time Occlusion Therapy for Intermittent Exotropia in Children Intermittent Exotropia | Phase 3 | 2022-11-01 |
| Completed | Time in Glucose Hospital Target Diabetes Mellitus, Type 2 | N/A | 2022-05-10 |
| Active Not Recruiting | Bevacizumab Treatment For Type 1 ROP Retinopathy of Prematurity | Phase 2 | 2022-05-01 |
| Terminated | A Randomized Trial of Low-Dose Bevacizumab vs Laser for Type 1 ROP Retinopathy of Prematurity | Phase 3 | 2022-04-27 |
| Recruiting | Randomized Trial Comparing Immediate vs. Deferred Surgery for Symptomatic ERM Epiretinal Membrane | N/A | 2022-02-22 |
| Active Not Recruiting | Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F Retinal Degeneration, Retinitis Pigmentosa, Eye Diseases, Hereditary | — | 2021-06-08 |
| Unknown | Hybrid Closed Loop Therapy and Verapamil for Beta Cell Preservation in New Onset Type 1 Diabetes (CLVer): Exte Type1 Diabetes | — | 2021-05-07 |
| Recruiting | Fenofibrate for Prevention of DR Worsening Diabetic Retinopathy | Phase 3 | 2021-03-05 |
| Recruiting | A Randomized Trial to Evaluate Sequential vs Simultaneous Patching Amblyopia | Phase 3 | 2020-12-08 |
| Completed | Automated Insulin Delivery in Elderly With Type 1 Diabetes (AIDE T1D) Type 1 Diabetes Mellitus | Phase 4 | 2020-09-28 |
| Completed | Virtual Diabetes Specialty Clinic: A Study Evaluating Remote Initiation of Continuous Glucose Monitoring Type 1 Diabetes, Type 2 Diabetes | N/A | 2020-08-24 |
| Completed | Hybrid Closed Loop Therapy and Verapamil for Beta Cell Preservation in New Onset Type 1 Diabetes Type1 Diabetes | Phase 3 | 2020-07-09 |
| Withdrawn | Excimer Laser Surgery for Anisometropic Amblyopia Anisometropic Amblyopia, Refractive Errors | N/A | 2020-06-01 |
| Completed | The Insulin-Only Bionic Pancreas Pivotal Trial Diabetes Mellitus, Type 1 Diabetes, Diabetes Mellitus, Type 1 | N/A | 2020-03-31 |
| Active Not Recruiting | Rate of Progression in EYS Related Retinal Degeneration Retinitis Pigmentosa, Eye Diseases | — | 2020-02-25 |
| Completed | Base-in Prism Spectacles for Intermittent Exotropia Exotropia Intermittent | N/A | 2019-09-01 |
| Completed | A Pilot Study Evaluating Photobiomodulation Therapy for Diabetic Macular Edema Diabetic Macular Edema | N/A | 2019-04-10 |
| Terminated | Surgical Idiopathic Intracranial Hypertension Treatment Trial Idiopathic Intracranial Hypertension | Phase 3 | 2019-02-06 |
| Completed | The Loop Observational Study Diabetes Mellitus, Type 1 | — | 2019-01-17 |
| Completed | Effects of Pneumatic Vitreolysis on Macular Hole Vitreomacular Traction (VMT), Full-thickness Macular Holes (MH) | N/A | 2018-11-14 |
| Completed | Effects of Pneumatic Vitreolysis on Vitreomacular Traction Vitreomacular Traction | Phase 3 | 2018-10-16 |
| Completed | Low-Dose Atropine for Treatment of Myopia Myopia | Phase 3 | 2018-06-01 |
| Completed | CGM Intervention in Teens and Young Adults With Type 1 Diabetes (T1D) Type 1 Diabetes Mellitus | Phase 3 | 2018-01-25 |
| Terminated | PROMINENT-Eye Ancillary Study (Protocol AD) Diabetic Retinopathy, Diabetic Macular Edema | Phase 3 | 2018-01-15 |
| Completed | DRCR.Net Aflibercept vs. Bevacizumab + Deferred Aflibercept for the Treatment of CI-DME Diabetic Macular Edema | Phase 3 | 2017-12-07 |
| Completed | Wireless Innovation for Seniors With Diabetes Mellitus Type 1 Diabetes Mellitus | N/A | 2017-09-26 |
| Active Not Recruiting | Rate of Progression in USH2A-related Retinal Degeneration Usher Syndrome, Type 2A, Retinitis Pigmentosa 39 | — | 2017-08-11 |
| Completed | Day and Night Closed-loop in Young People With Type 1 Diabetes Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders | N/A | 2017-05-12 |
| Completed | Binocular Dig Rush Game Treatment for Amblyopia Amblyopia | N/A | 2017-03-02 |
| Completed | Strategies to Enhance New CGM Use in Early Childhood (SENCE) Type 1 Diabetes Mellitus | N/A | 2017-01-30 |
| Completed | Trial of Overminus Spectacle Therapy for Intermittent Exotropia Intermittent Exotropia | N/A | 2017-01-16 |
| Completed | Anti-VEGF vs. Prompt Vitrectomy for VH From PDR Proliferative Diabetic Retinopathy, Vitreous Hemorrhage | Phase 2 / Phase 3 | 2016-11-01 |
| Completed | Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms, Pump Suspension Type 1 Diabetes, Hypoglycemia, Hyperglycemia | Phase 2 | 2016-05-01 |
| Completed | The Use of Mini-dose Glucagon to Prevent Exercise-induced Hypoglycemia in Type 1 Diabetes Diabetes Mellitus, Type 1 | Phase 2 | 2016-01-01 |
| Completed | Anti-VEGF Treatment for Prevention of PDR/DME Diabetic Retinopathy, Diabetic Macular Edema | Phase 3 | 2016-01-01 |
| Completed | Mini-Dose Glucagon to Treat Non-Severe Hypoglycemia Diabetes Mellitus, Type 1 | Phase 2 | 2015-09-01 |
| Completed | A Prospective Observational Study of Adult Strabismus Convergence Insufficiency, Divergence Insufficiency, Hypertropia | — | 2015-08-17 |
| Completed | Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms Type 1 Diabetes | Phase 2 | 2015-06-01 |
| Completed | Phase 1 Trial of Bevacizumab Treatment for Severe Retinopathy of Prematurity Retinopathy of Prematurity | Phase 1 | 2015-04-28 |
| Completed | A Trial Comparing Continuous Glucose Monitoring With and Without Routine Blood Glucose Monitoring in Adults Wi Type 1 Diabetes | N/A | 2015-03-01 |
| Completed | A Pilot Clinical Trial of Overminus Spectacle Therapy for Intermittent Exotropia Intermittent Exotropia | N/A | 2014-12-01 |
| Completed | Study of Binocular Computer Activities for Treatment of Amblyopia Amblyopia | N/A | 2014-09-11 |
| Completed | Pilot Study 3 of Outpatient Control-to-Range: Safety and Efficacy With Day-and-Night In-Home Use Type 1 Diabetes | N/A | 2014-08-01 |
| Completed | Phase II Combination Steroid and Anti-VEGF for Persistent DME Diabetic Macular Edema | Phase 2 | 2014-02-01 |
| Completed | Insulin Clamp Ancillary Study for Assessment of Insulin Resistance Type 1 Diabetes | Phase 3 | 2014-01-01 |
| Completed | Treatment for CI-DME in Eyes With Very Good VA Study Diabetic Macular Edema | Phase 3 | 2013-10-01 |
| Completed | Metformin Therapy for Overweight Adolescents With Type 1 Diabetes Type 1 Diabetes | Phase 3 | 2013-09-01 |
| Completed | Outpatient Reduction of Nocturnal Hypoglycemia by Using Predictive Algorithms and Pump Suspension in Children Type 1 Diabetes | Phase 2 | 2013-05-01 |
| Completed | Outpatient Pump Shutoff Pilot Feasibility and Efficacy Study Type 1 Diabetes | Phase 2 | 2012-11-01 |
| Completed | Comparative Effectiveness Study of Intravitreal Aflibercept, Bevacizumab, and Ranibizumab for Diabetic Macular Diabetic Macular Edema | Phase 3 | 2012-08-01 |
| Completed | Convergence Insufficiency Treatment Study (CITS) Convergence Insufficiency | N/A | 2012-06-01 |
| Completed | Prompt Panretinal Photocoagulation Versus Ranibizumab+Deferred Panretinal Photocoagulation for Proliferative D Proliferative Diabetic Retinopathy | Phase 3 | 2012-03-01 |
| Completed | Hyperopia Treatment Study 1 (HTS1) - Glasses vs Observation Hyperopia | N/A | 2012-02-23 |
| Completed | An Outpatient Pump Shutoff Pilot Feasibility and Safety Study Type 1 Diabetes | Phase 2 | 2012-01-01 |
| Completed | Effect of Diabetes Education During Retinal Ophthalmology Visits on Diabetes Control Diabetes, Diabetic Retinopathy | Phase 3 | 2011-10-01 |
| Completed | NSAID Phase II for Non-central Involved Diabetic Macular Edema (DME) Diabetic Macular Edema | Phase 2 | 2011-05-01 |
| Completed | Inpatient Evaluation of an Automated Closed-Loop Control-to-Range System Type 1 Diabetes | Phase 1 | 2011-03-01 |
| Completed | Randomized Trial to Assess Efficacy and Safety of Continuous Glucose Monitoring in Children 4-<10 Years With T Diabetes Mellitus, Type 1 | Phase 3 | 2010-09-01 |
| Completed | Levodopa for the Treatment of Residual Amblyopia Amblyopia | Phase 3 | 2010-09-01 |
| Terminated | Effect of Metabolic Control at Onset of Diabetes on Progression of Type 1 Diabetes Type 1 Diabetes | Phase 2 / Phase 3 | 2010-09-01 |
| Completed | Intravitreal Ranibizumab for Vitreous Hemorrhage Due to Proliferative Diabetic Retinopathy (N) Vitreous Hemorrhage, Proliferative Diabetic Retinopathy | Phase 2 / Phase 3 | 2010-06-01 |
| Completed | Bilateral Lateral Rectus Recession Versus Unilateral Recess-Resect for Intermittent Exotropia Exotropia | N/A | 2010-06-01 |
| Completed | Observation Versus Occlusion Therapy for Intermittent Exotropia Exotropia | N/A | 2010-01-01 |
| Completed | Augmenting Atropine Treatment for Amblyopia in Children 3 to < 8 Years Old Amblyopia | Phase 3 | 2009-08-01 |
| Completed | Increasing Patching for Amblyopia in Children 3 to < 8 Years Old Amblyopia | Phase 3 | 2009-08-01 |
| Completed | Pilot Study to Evaluate Levodopa as Treatment for Residual Amblyopia Amblyopia | Phase 2 | 2009-01-01 |
| Completed | Immediate Office Probing vs Deferred Facility Probing for Nasolacrimal Duct Obstruction in Children 6 to <10 M Nasolacrimal Duct Obstruction | Phase 3 | 2008-10-01 |
| Completed | Continuous Glucose Sensor Profiles in Non-Diabetic Subjects Healthy Subjects Without Type 1 Diabetes | Phase 4 | 2008-07-01 |
| Completed | Observational Study of Optical Correction for Strabismic Amblyopia in Children 3 to <7 Years Old Amblyopia | — | 2008-05-01 |
| Terminated | Trial Comparing Patching With Active Vision Therapy to Patching With Control Vision Therapy as Treatment for A Amblyopia | Phase 3 | 2008-04-01 |
| Completed | A Pilot Study to Evaluate the Safety of Terbutaline in Children With Type 1 Diabetes Type 1 Diabetes | Phase 1 | 2008-02-01 |
| Completed | Full-time Bangerter Filters Versus Part-time Daily Patching for Moderate Amblyopia in Children Amblyopia | Phase 3 | 2007-11-01 |
| Terminated | Combined Patching-Atropine for Residual Amblyopia Amblyopia | Phase 3 | 2007-10-01 |
| Completed | Laser-Ranibizumab-Triamcinolone for Diabetic Macular Edema Diabetic Retinopathy, Diabetic Macular Edema | Phase 3 | 2007-03-01 |
| Completed | Laser-Ranibizumab-Triamcinolone for Proliferative Diabetic Retinopathy Proliferative Diabetic Retinopathy, Diabetic Macular Edema | Phase 3 | 2007-03-01 |
| Completed | The Course of Response to Focal Photocoagulation for DME Diabetic Retinopathy, Diabetic Macular Edema | — | 2007-01-01 |
| Completed | Hormone Responses During Hypoglycemia and the Accuracy of Continuous Glucose Monitors Type 1 Diabetes | — | 2006-12-01 |
| Completed | Randomized Study of Real-Time Continuous Glucose Monitors (RT-CGM) in the Management of Type 1 Diabetes Type 1 Diabetes | Phase 3 | 2006-12-01 |
| Completed | A Phase 2 Evaluation of Anti-VEGF Therapy for Diabetic Macular Edema: Bevacizumab (Avastin) Diabetic Retinopathy | Phase 2 | 2006-06-01 |
| Completed | Effect of the Fat Content of the Bedtime Snack on Overnight Hypoglycemia Diabetes Mellitus, Type I | — | 2006-03-01 |
| Completed | Observational Study of DME Following Scatter Laser Photocoagulation Diabetic Macular Edema | N/A | 2005-09-01 |
| Completed | Pilot Study of the Navigator Continuous Glucose Monitor Diabetes Mellitus, Insulin-Dependent | Phase 2 / Phase 3 | 2005-08-01 |
| Completed | Trial Comparing Patching Versus Atropine for Amblyopia in 7 to < 13 Year Olds Amblyopia | Phase 3 | 2005-08-01 |
| Completed | Evaluation of Vitrectomy for Diabetic Macular Edema Diabetic Retinopathy, Diabetic Macular Edema | — | 2005-07-01 |
| Completed | The Effect of Insulin During Exercise on the Development of Low Blood Sugar in Individuals With Type I Diabete Diabetes Mellitus, Type I | — | 2005-05-01 |
| Completed | Correction of Myopia Evaluation Trial 2 Myopia | Phase 3 | 2005-04-01 |
| Completed | Study of Surgical Procedures for Treatment of Persistent Nasolacrimal Duct Obstruction in Children < 4 Years O Nasolacrimal Duct Obstruction | — | 2005-02-01 |
| Completed | Trial Comparing Near Versus Distance Activities While Patching for Amblyopia in Children 3 to <7 Years Old Amblyopia | Phase 3 | 2005-02-01 |
| Completed | Trial Comparing Atropine to Atropine Plus a Plano Lens for the Sound Eye for Amblyopia in Children 3 to <7 Yea Amblyopia | Phase 3 | 2005-02-01 |
| Completed | Study of Primary Surgical Treatment of Nasolacrimal Duct Obstruction in Children Less Than Four Years Old Nasolacrimal Duct Obstruction | — | 2005-02-01 |
| Completed | A Pilot Study of Peribulbar Triamcinolone Acetonide for Diabetic Macular Edema Diabetic Macular Edema | Phase 2 | 2004-12-01 |
| Completed | Bilateral Refractive Amblyopia Treatment Study Bilateral Refractive Amblyopia | — | 2004-08-01 |
| Completed | Intravitreal Triamcinolone Acetonide Versus Laser for Diabetic Macular Edema Diabetic Macular Edema | Phase 3 | 2004-07-01 |
| Completed | Study to Determine the Relationship Between Exercise and Hypoglycemia in Children With Type 1 Diabetes Diabetes Mellitus, Type I | — | 2004-06-01 |
| Completed | An Observational Study of Infantile, Acquired Non-accommodative, and Acquired Partially-accommodative Esotropi Infantile Esotropia, Acquired Non-accommodative Esotropia, Acquired Partially Accommodative Esotropia | — | 2004-06-01 |
| Completed | Trial to Evaluate 2 Hours of Daily Patching for Amblyopia in Children Amblyopia | Phase 3 | 2004-02-01 |
| Completed | Randomized Clinical Trial to Assess the Effectiveness of the GlucoWatch Biographer Diabetes Mellitus, Insulin-Dependent | Phase 4 | 2003-07-01 |
| Completed | A Pilot Study of Laser Photocoagulation for Diabetic Macular Edema Diabetic Macular Edema | Phase 2 | 2003-07-01 |
| Completed | Pilot Study of the GlucoWatch G2 Biographer for the Management of Type 1 Diabetes in Children Diabetes Mellitus, Insulin-Dependent | Phase 4 | 2003-02-01 |
| Completed | An Evaluation of Treatment of Amblyopia in Children 7 To <18 Years Old Amblyopia | Phase 3 | 2002-10-01 |
| Completed | Assessing Continuous Glucose Monitors in Healthy Children Diabetes Mellitus | Phase 4 | 2002-08-01 |
| Completed | Trial Comparing Daily Atropine Versus Weekend Atropine Amblyopia | Phase 4 | 2002-06-01 |
| Completed | Continuous Glucose Monitors for Children With Diabetes Mellitus Diabetes Mellitus, Insulin-Dependent | Phase 4 | 2002-05-01 |
| Completed | Trial Comparing Part-time Versus Minimal-time Patching for Moderate Amblyopia Amblyopia | Phase 3 | 2001-05-01 |
| Completed | Trial Comparing Part-time Versus Full-time Patching for Severe Amblyopia Amblyopia | Phase 3 | 2001-05-01 |
| Completed | Occlusion Versus Pharmacologic Therapy for Moderate Amblyopia Amblyopia | Phase 3 | 1999-04-01 |