| Not Yet Recruiting | Immune Checkpoint Inhibitor (ICI)-Drug-Drug Interaction (DDI) Study NCT07389525 | Indiana University | EARLY_Phase 1 |
| Recruiting | Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy NCT07222800 | Pfizer | Phase 3 |
| Recruiting | A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors Aft NCT07218926 | GlaxoSmithKline | Phase 3 |
| Recruiting | A Real-World Study of Fecal Transplants for Cancer Therapy Side Effects NCT07319364 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 1 |
| Recruiting | A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants Wi NCT06885034 | GlaxoSmithKline | Phase 1 / Phase 2 |
| Recruiting | Impact of Oral Versus Intravenous 5-FU-Based Adjuvant Regimens on Sleep Quality and Depression in Patients Wit NCT06996483 | Ankara Etlik City Hospital | — |
| Not Yet Recruiting | Feasibility and Prospective Study of a Dynamic Traction Device for Use During ESD NCT06747988 | Baylor College of Medicine | — |
| Recruiting | A Study of JNJ-89402638 for Metastatic Colorectal and Gastric Cancers NCT06663319 | Janssen Research & Development, LLC | Phase 1 |
| Enrolling By Invitation | Longitudinal Study on the Evolution Trend and Influencing Factors of Postoperative Reflux of Esophageal Cancer NCT06509022 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | — |
| Unknown | Endostar Combined With SBRT and Envafolimab in the Treatment of Advanced Gastrointestinal Tumors NCT06301828 | Nanjing First Hospital, Nanjing Medical University | Phase 2 |
| Recruiting | Evaluate the Efficacy of Adding Intraluminal Brachytherapy After CCRT for Local-regional Thoracic Esophageal C NCT06365866 | Taipei Veterans General Hospital, Taiwan | N/A |
| Recruiting | SGM-101 in Colorectal Brain Metastases. NCT04755920 | Leiden University Medical Center | Phase 2 |
| Active Not Recruiting | Avatrombopag vs. Placebo for CIT in GI Malignancies NCT05772546 | Hanny Al-Samkari, MD | Phase 2 |
| Recruiting | PPG vs. ICG in Gastrointestinal Resections NCT06222645 | Saint Petersburg State University, Russia | N/A |
| Completed | Pilot Study to Determine Pro-Inflammatory Cytokine Kinetics During Immune Checkpoint Inhibitor Therapy NCT05707286 | Indiana University | — |
| Terminated | Study of EO-3021 in Adult Patients With Solid Tumors Likely to Express CLDN18.2 NCT05980416 | Elevation Oncology | Phase 1 |
| Active Not Recruiting | Multidisciplinary Approach to Nutritional Support for Oncological Patients - NUTRACARE PROJECT NCT06869707 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Unknown | Application of IPC During Surgery to Prevent Venous Thrombosis in Gastrointestinal Surgery Patients. NCT06260150 | Feng Tian | N/A |
| Completed | A Comparative Study of CCI, EmSFI, and FTRST Scoring Systems NCT06943924 | Dr. Lutfi Kirdar Kartal Training and Research Hospital | — |
| Completed | A Prospective, Multicenter Randomized Controlled Study of the Application of Preoperative FOLFOXIRI Chemothera NCT06048146 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | N/A |
| Unknown | Effects of Different Doses of Vitamin D on Cancer-related Cognitive Impairment in Patients With Gastrointestin NCT05552729 | Yangzhou University | Phase 1 / Phase 2 |
| Active Not Recruiting | CRC Detection Reliable Assessment With Blood NCT05551052 | New Day Diagnostics | — |
| Completed | Cost-effective Analysis of Two Approximation Devices in Closure of Gastrointestinal Defects NCT05163665 | Baylor College of Medicine | N/A |
| Recruiting | First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal T NCT05489237 | IDRX, Inc., a wholly owned subsidiary of GSK, LLC | Phase 1 |
| Withdrawn | Gastrointestinal Anastomosis Using MonoPlus® Suture NCT04811833 | Aesculap AG | — |
| Recruiting | Anlotinib Hydrochloride Capsules Combined With TQB2450 Injection in Esophageal Squamous Cell Carcinoma Patient NCT05252078 | Jiangxi Provincial Cancer Hospital | Phase 2 |
| Unknown | PTC in Personalizing Neoadjuvant Therapy for Patients With Advanced Gastrointestinal Tumor NCT05280210 | Peking University | N/A |
| Recruiting | XELOX Combined With Anlotinib and Penpulimab vs XELOX as Adjuvant Therapy in ctDNA Positive Gastric and Esopha NCT05494060 | The First Affiliated Hospital with Nanjing Medical University | Phase 2 |
| Unknown | Endoscopic Vital Nerve Staining in Gastrointestinal Diseases NCT05232357 | Affiliated Hospital to Academy of Military Medical Sciences | EARLY_Phase 1 |
| Active Not Recruiting | Monopolar Current Cutting Knife vs Bipolar RFA Knife NCT04919824 | Baylor College of Medicine | N/A |
| Completed | Clinical Study on Continuous Suture of Endoscopic Mucosal Defects NCT05190042 | Affiliated Hospital to Academy of Military Medical Sciences | N/A |
| Terminated | A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST) NCT05160168 | Theseus Pharmaceuticals | Phase 1 / Phase 2 |
| Unknown | Remote Real-Time Guidance System in Home Care of Patients With PICC or PORT NCT05106244 | First Affiliated Hospital Xi'an Jiaotong University | N/A |
| Unknown | Defining Robust Predictors of Chemotherapy Related Cardiotoxicity NCT05159479 | University College, London | — |
| Recruiting | Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes NCT04907643 | Cedars-Sinai Medical Center | N/A |
| Recruiting | Evaluation of Neoplasia With Artificial Intelligence in Gastrointestinal Endoscopy NCT04937647 | Portsmouth Hospitals NHS Trust | — |
| Completed | Retrospective Review of Gastrointestinal System Endoscopy Procedures NCT05012527 | Istanbul Sultanbeyli State Hospital | — |
| Completed | ConMed Beamer Study NCT04752670 | Baylor College of Medicine | — |
| Terminated | A Home-Based Approach Study to Evaluate the Efficacy and Safety of Alectinib in Locally-Advanced or Metastatic NCT04644315 | Hoffmann-La Roche | Phase 2 |
| Recruiting | Spanish Series of Patients Treated With the Radionuclide Lutetium177 NCT04949282 | Sociedad Española de Medicina Nuclear e Imagen Molecular | — |
| Completed | Usefulness of GI-GENIUS in FIT-based Colorectal Cancer Screening Program. NCT04673136 | Asociación Española de Gastroenterología | N/A |
| Recruiting | Interaction Between Host, Microenvironment and Immunity on Gastrointestinal Neoplasms NCT04363983 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | The Use of a OCT Probe in Assessment of Endoscopic and Surgical Resection Specimen of Gastrointestinal Tract NCT04670718 | Chinese University of Hong Kong | N/A |
| Active Not Recruiting | Assessing Durvalumab and FLOT Chemotherapy in Resectable Gastric and Gastroesophageal Junction Cancer NCT04592913 | AstraZeneca | Phase 3 |
| Unknown | Palliative Primary Tumor Resection in Minimally Symptomatic Patients With Colorectal Cancer and Synchronous Un NCT05322486 | State Scientific Centre of Coloproctology, Russian Federation | — |
| Completed | Artificial Intelligence in Colonic Polyp Detection NCT05178095 | Sahlgrenska University Hospital | N/A |
| Completed | Utility of OverStitch Sx After ESD NCT04361227 | Baylor College of Medicine | — |
| Completed | A Study of Metastatic Gastrointestinal Cancers Treated With Tumor Infiltrating Lymphocytes in Which the Gene E NCT04426669 | Intima Bioscience, Inc. | Phase 1 / Phase 2 |
| Completed | Ulixertinib (BVD-523) and Hydroxychloroquine in Patients W Advanced MAPK-Mutated Gastrointestinal Adenocarcino NCT04145297 | University of Utah | Phase 1 |
| Completed | A Study to Find a Safe and Effective Dose of BI 905711 in Patients With Advanced Gastrointestinal Cancer NCT04137289 | Boehringer Ingelheim | Phase 1 |
| Active Not Recruiting | ctDNA-guided Surveillance for Stage III CRC, a Randomized Intervention Trial NCT04084249 | Claus Lindbjerg Andersen | N/A |
| Completed | Anlotinib Hydrochloride Capsules Combined With CAPEOX in RAS and BRAF Wild-type mCRC Patients NCT04080843 | Zhejiang University | Phase 2 |
| Completed | Telephone Support for Advanced Gastrointestinal Cancer Patients and Caregivers NCT04010227 | Indiana University | N/A |
| Unknown | The Maintenance Treatment of Apatinib/Capecitabine Versus Observation in Advanced Gastric Cancer NCT03889626 | Fudan University | Phase 3 |
| Unknown | FOLFIRINOX vs FLOT Chemotherapy for Resectable Gastric or Esophagogastric Junction Adenocarcinoma NCT04393584 | Blokhin's Russian Cancer Research Center | Phase 2 / Phase 3 |
| Completed | Evaluation of Ocoxin®-Viusid® in Metastatic Colorectal Adenocarcinoma NCT03559543 | Catalysis SL | Phase 2 |
| Completed | Evaluation of Ocoxin®-Viusid® in Advanced Stomach Cancer and Gastric Esophagogastric Junction NCT03549494 | Catalysis SL | Phase 2 |
| Unknown | Indocyanine Green Fluorescence Imaging in Prevention of Colorectal Anastomotic Leakage NCT03602677 | Oulu University Hospital | N/A |
| Completed | A Study of RGX-202-01 (Ompenaclid) as Combination Therapy in RAS Mutant Advanced Colorectal Cancer NCT03597581 | Inspirna, Inc. | Phase 1 |
| Unknown | Apatinib Versus Bevacizumab in Second-line Therapy for Colorectal Cancer(ABST-C) NCT03271255 | Shenzhen People's Hospital | Phase 2 |
| Completed | The Effect of Blood Pressure on Cerebral Blood Flow During Propofol Anesthesia NCT03309917 | Rigshospitalet, Denmark | N/A |
| Unknown | Clinical Trial of Electroacupuncture Stimulation on Prevention and Treatment of Oxaliplatin Neurotoxicity NCT03330964 | The First Affiliated Hospital of Dalian Medical University | N/A |
| Completed | A Study of IMU-131(HER-Vaxx) and Chemotherapy Compared to Chemotherapy Only in Patients With HER2 Positive Adv NCT02795988 | Imugene Limited | Phase 1 / Phase 2 |
| Unknown | Radiomics for Prediction of Lymph Node Metastasis in Gastric Cancer（RPLNM）(GIPMCS-1701) NCT03488446 | Nanfang Hospital, Southern Medical University | — |
| Terminated | Study of Lanreotide in Patients With Metastatic Gastrointestinal Neuroendocrine Tumors Who Are Undergoing Live NCT02859064 | SCRI Development Innovations, LLC | Phase 2 |
| Completed | Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Can NCT03037385 | Hoffmann-La Roche | Phase 1 / Phase 2 |
| Unknown | Endoscopic Resection Multicenter Registry NCT03065257 | Weill Medical College of Cornell University | — |
| Terminated | EUS-Endodrill vs. EUS-FNA for Diagnosis of Submucosal Tumors in the Upper GI Tract NCT02744651 | Region Skane | N/A |
| Completed | Cerebral Blood Flow During Propofol Anaesthesia NCT02951273 | Rigshospitalet, Denmark | — |
| Unknown | Clinical Trial on Acupuncture Therapy in Patients With Gastrointestinal Neoplasms Laparoscopic Surgery NCT02871245 | Xiaonan Cui | N/A |
| Completed | Outcomes of Side-to-end Versus End-to-end Colorectal Anastomosis in Non-emergent Sigmoid and Rectal Cancers: R NCT04694521 | Zagazig University | N/A |
| Unknown | Clinical Trial of Cinobufacini Injection Combined With Oxaliplatin Regimen on Gastrointestine Carcinoma NCT02860429 | Xiaonan Cui | Phase 4 |
| Terminated | Hemostatic Powder Versus Clinical Management for the Treatment of Upper Gastrointestinal Bleeding From Tumor L NCT02820077 | Instituto do Cancer do Estado de São Paulo | N/A |
| Unknown | Clinical Trial on Ganoderma Spore Lipids Combined With Chemo in Patients With G.I. Cancers NCT02785523 | Xiaonan Cui | Phase 3 |
| Unknown | EUS-FNB vs. Single-incision Needle-knife (SINK) Biopsy for Gastrointestinal SELs NCT02866045 | Unity Health Toronto | Phase 3 |
| Unknown | Oncogeriatric Intervention and Follow-up at Home NCT02837679 | Aarhus University Hospital | N/A |
| Unknown | Tamoxifen in Patients With Oesophageal Cancer NCT02513849 | University of Nottingham | Phase 1 |
| Completed | Comparison of Thromboembolic Events in Patients Undergoing Thromboprophylactic Treatment With ENOXA® vs Loveno NCT02444572 | Les Laboratoires des Médicaments Stériles | Phase 4 |
| Unknown | Novel Endoscopic Imaging Methods for the Evaluation of Blood Vessels in Gastrointestinal Cancers NCT02672774 | University of Medicine and Pharmacy Craiova | N/A |
| Completed | Aprepitant Triple Therapy for the Prevention of CINV in Nondrinking and Young Women Who Received Moderately Em NCT03674294 | Sun Yat-sen University | Phase 3 |
| Completed | Evaluating Strategies to Present Colon Cancer Screening Information NCT02485561 | Washington University School of Medicine | N/A |
| Completed | Study of PRoliferation and Apoptosis in Rectal Cancer, Predictive & Prognostic biOmarkers: Histopathology and NCT02486094 | Royal Marsden NHS Foundation Trust | — |
| Unknown | Afatinib and Selumetinib in Advanced KRAS Mutant and PIK3CA Wildtype Non-small Cell Lung Cancer NCT02450656 | The Netherlands Cancer Institute | Phase 1 / Phase 2 |
| Terminated | AZD9150, a STAT3 Antisense Oligonucleotide, in People With Malignant Ascites NCT02417753 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Transvaginal Versus Transabdominal Extraction of Laparoscopically-excised Specimen NCT05113134 | Seoul National University Bundang Hospital | N/A |
| Unknown | Improvement of Colonoscopy Preparation by New Media (APP) NCT02512328 | Technical University of Munich | Phase 1 |
| Unknown | Safety Study of Combining Ultrasound Microbubbles and Chemotherapy to Treat Malignant Neoplasms of Digestive S NCT02233205 | Peking University Cancer Hospital & Institute | Phase 1 / Phase 2 |
| Terminated | Probiotic LGG for Prevention of Side Effects in Patients Undergoing Chemoradiation for Gastrointestinal Cancer NCT01790035 | Washington University School of Medicine | Phase 1 |
| Unknown | Study of Autologous Tumor Lysate-pulsed D-CIK Combined With Chemotherapy for Gastric Cancer NCT02215837 | Shenzhen Hornetcorn Bio-technology Company, LTD | Phase 2 |
| Completed | Mesenteric Traction Syndrome During Upper Gastrointestinal Surgery NCT02507414 | Rigshospitalet, Denmark | N/A |
| Terminated | An International, Multicentric, Prospective, Observational Study to Evaluate Monosyn® Suture Material for Anas NCT02080702 | Aesculap AG | — |
| Unknown | Intestinal Microflora in Colorectal Cancer (CRC) After Chemotherapy NCT02169388 | Shandong University | Phase 1 |
| Unknown | Endoscopic Ultrasound in Detailed T-staging of Upper GI Malignancies in Vitro NCT02226224 | Peking University Cancer Hospital & Institute | — |
| Completed | A Phase III Study of 2nd-line XELIRI ± Bevacizumab vs. FOLFIRI ± Bevacizumab in mCRC NCT01996306 | Epidemiological and Clinical Research Information Network | Phase 3 |
| Completed | Intervention to Motivate Standing &Walking in Gastrointestinal Cancer Surgical Patients NCT01982994 | Milton S. Hershey Medical Center | N/A |
| Completed | Functional MRI of Hypoxia-mediated Rectal Cancer Aggressiveness NCT01816607 | University Hospital, Akershus | — |
| Completed | Induction Chemotherapy, Chemoradiotherapy and Surgery in Locally Advanced Gastric Cancer Patients NCT02454647 | Clinica Universidad de Navarra, Universidad de Navarra | — |
| Active Not Recruiting | Crossover Trial of Systemic Chemotherapy in Patients With Metastatic Well-Differentiated Mucinous Appendiceal NCT01946854 | M.D. Anderson Cancer Center | N/A |
| Unknown | Molecular, Pathologic and MRI Investigation of the Prognostic and Redictive Importance of Extramural Venous In NCT01995942 | Royal Marsden NHS Foundation Trust | — |
| Unknown | Efficacy and Safety of Endoscopic Resection NCT03050333 | EDUARDO ALBENIZ | — |
| Terminated | Mithramycin for Lung, Esophagus, and Other Chest Cancers NCT01624090 | National Cancer Institute (NCI) | Phase 2 |
| Completed | S-1, Oxaliplatin, and Irinotecan for Advanced Gastrointestinal Cancer NCT01693445 | Hallym University Medical Center | Phase 1 |
| Unknown | A Study of 2nd-line FOLFIRI ± Bevacizumab vs. Irinotecan ± Bevacizumab in mCRC NCT03303495 | Sun Yat-sen University | Phase 3 |
| Recruiting | Clinical Outcomes of the Endoscopic Resection of Premalignant and Malignant Gastrointestinal Lesions NCT01750619 | California Pacific Medical Center Research Institute | — |
| Completed | Phase II Study of Everolimus Combined With Octreotide LAR to Treat Advanced GI NET NCT01567488 | Grupo Espanol de Tumores Neuroendocrinos | Phase 2 |
| Withdrawn | Acupuncture for the Immune System in Radiation Cancer Patients NCT01422928 | British Columbia Cancer Agency | Phase 3 |
| Completed | A Phase I Study of S-1 in Combination With Radiotherapy in Locally Advanced or Recurrent Gastric Cancer NCT01291407 | Chinese Academy of Medical Sciences | Phase 1 |
| Unknown | Los Angeles Prospective GI Biliary and EUS Series NCT02196935 | University of Southern California | — |
| Completed | Endoscopic Submucosal Dissection Registry NCT01415609 | Mayo Clinic | — |
| Terminated | Prospective Randomized Trial of Anterograde Single Balloon Versus Spirus Enteroscopy NCT01853241 | Johns Hopkins University | — |
| Withdrawn | Collection of Biospecimen & Clinical Information in Patients w/ Gastrointestinal Cancers NCT01031056 | Stanford University | — |
| Unknown | Optimum Timing for Surgery After Pre-operative Radiotherapy 6 vs 12 Weeks NCT01037049 | Royal Marsden NHS Foundation Trust | Phase 2 |
| Terminated | Permission to Collect Blood Over Time for Research NCT00767234 | Stanford University | — |
| Completed | A Phase 2 Study of XL820 in Adults With Advanced GIST Resistant to Imatinib and/or Sunitinib NCT00570635 | Exelixis | Phase 2 |
| Unknown | Low Rectal Cancer Study (MERCURY II) NCT02005965 | Royal Marsden NHS Foundation Trust | — |
| Unknown | Bone Marrow-derived Cells' Contribution to Tumor Formation and Inflammation NCT00452205 | Komagome Hospital | — |
| Completed | Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Cisplatin for Children With Peritoneal Cancer NCT00436657 | M.D. Anderson Cancer Center | Phase 1 |
| Completed | Endoscopic Stenting of Gastrointestinal Cancer NCT00422409 | Ullevaal University Hospital | N/A |
| Terminated | Study of BMS-582664 in Combination With Either FOLFIRI or FOLFOX for Gastrointestinal (GI) Malignancies NCT00300027 | Bristol-Myers Squibb | Phase 1 |
| Completed | High Dose Somatostatin Analogues in Neuroendocrine Tumors NCT00990535 | Federico II University | Phase 2 |
| Completed | The Impact of Low Calorie and Low Nitrogen Parenteral Nutrition Support on the Clinical Outcome of Postoperati NCT00247338 | Sino-Swed Pharmaceutical Corporation | Phase 4 |
| Completed | Effect of an Antioxidant on Cancer-Cachectic Patients Undergoing Exercise Training NCT00196885 | German Cancer Research Center | Phase 2 |
| Completed | Low Dose Upper Abdominal Radiation Therapy (LD-UART) + Gemcitabine in Patients With Advanced, Unresectable Pan NCT00390182 | University of Maryland, Baltimore | Phase 1 / Phase 2 |
| Completed | Phase 2 Study on Use of a Combination of Pemetrexed in Patients With Advanced Gastric Carcinoma NCT00190801 | Eli Lilly and Company | Phase 2 |
| Completed | Magnetic-Targeted Doxorubicin in Treating Patients With Cancer Metastatic to the Liver NCT00041808 | FeRx | Phase 1 / Phase 2 |
| Completed | Study With Mitomycin c/5-FU/FA in Pretreated Gastrointestinal Cancer Patients With Metastases (>= Second-line NCT00289445 | University Hospital Tuebingen | Phase 1 / Phase 2 |
| Completed | A Phase I Trial of Gemcitabine and Radiation in Locally Advanced Unresectable Cancer of the Pancreas NCT00001431 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Study of Motexafin Gadolinium and Docetaxel for Advanced Cancer NCT00120939 | Pharmacyclics LLC. | Phase 1 |