NCT05159479

Defining Robust Predictors of Chemotherapy Related Cardiotoxicity

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 600 (estimated)
• Sponsor: University College, London · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

Observational prospective cohort study designed for patients with gastrointestinal cancers receiving a fluoropyrimidine based chemotherapy regimen.

Detailed description

All enrolled participants will undergo baseline cardiovascular risk assessment (using QRISK3 and SCORE 2 risk calculators), cardiac, oncological and medication history. All participants will have serial cardiac symptom assessment, 12 lead ECG and cardiac biomarker assessments(high sensitivity troponin T and NT pro BNP) at baseline, on completion of the first cycle of treatment and post completion of treatment. Participants will be followed up for the development of cardiotoxicity.

Conditions

• Cardiotoxicity
• Gastrointestinal Neoplasms

Timeline

• Start date: 2021-10-13
• Primary completion: 2024-04-01
• Completion: 2024-07-01
• First posted: 2021-12-16
• Last updated: 2023-09-21

Locations

1 site across 1 country: United Kingdom