| Not Yet Recruiting | A Repeat Ascending Dosing Study of the Safety and Clinical Activity of R-3750 in Patients With Mild to Moderat NCT07076290 | Rise Therapeutics LLC | Phase 1 |
| Recruiting | Emotional-distress-based Integrated Care Programme in Patients With an Acute Exacerbation of COPD NCT07351929 | University of Zurich | N/A |
| Not Yet Recruiting | The COPD CARE Study: Evaluating the Impact of a Virtual-First COPD Service on Major Cardiac and Respiratory Ev NCT06379529 | NuvoAir Medical PC | N/A |
| Enrolling By Invitation | Study on Home Obstructive Respiratory Exacerbations NCT06544928 | Strados Labs, Inc. | — |
| Recruiting | High-intensity Resistance Training in Post-exacerbation COPD NCT07302425 | Istituti Clinici Scientifici Maugeri SpA | N/A |
| Recruiting | Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease NCT05703919 | Central Denmark Region | Phase 4 |
| Enrolling By Invitation | Telehealth Education Leveraging Electronic Transitions Of Care for COPD Patients NCT05897125 | University of Chicago | N/A |
| Recruiting | Supported Rescue Packs Post-discharge in Chronic Obstructive Pulmonary Disease NCT06347536 | Guy's and St Thomas' NHS Foundation Trust | Phase 3 |
| Not Yet Recruiting | Study of Sleep Quality in the Intensive Care Unit and Association with Weaning from Invasive Ventilation in Pa NCT06653933 | University Hospital, Grenoble | — |
| Recruiting | Role of Oral Care in Prevention of Nosocomial Pneumonia Among COPD Patients NCT06691399 | Assiut University | N/A |
| Completed | The Effect of Stress Ball on COPD Patients Receiving Noninvasive Mechanical Ventilation Support NCT06461169 | Kafkas University | N/A |
| Completed | Impulse Oscillometry in COPD Exacerbation NCT07185581 | Deniz Bilici | — |
| Recruiting | Impact of Continuous Positive Airway Pressure on the Occurrence of Acute Exacerbations of COPD in Patients Wit NCT05958563 | University Hospital, Angers | N/A |
| Unknown | Comfort of Patients Under Non Invasive Ventilation According to the Mask NCT06212180 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | A Study Evaluating the Use of ResAppDx v2.0 as an Aid to Diagnose Respiratory Disease in Adolescent and Adult NCT06156462 | ResApp Health Limited | — |
| Unknown | Exacerbantes Study NCT06147206 | Sociedad Española de Neumología y Cirugía Torácica | — |
| Unknown | Prehospital Non-invasive Ventilation for Acute Exacerbation of Chronic Obstructive Pulmonary Disease NCT06211920 | Central Denmark Region | N/A |
| Completed | PSV Versus ASV With Intellisync Mode for Delivery of NIV in AECOPD NCT06160687 | Post Graduate Institute of Medical Education and Research, Chandigarh | N/A |
| Unknown | Ultrasonographic Evaluation of Diaphragm and Quadriceps in Chronic Obstructive Pulmonary Disease (COPD) Patien NCT04509128 | IRCCS San Raffaele Roma | — |
| Unknown | Ferroptosis in Patients With COPD COPD With/Without Risk of Cardiovascular Events. Pathophysiological Implicat NCT06102993 | Hospital Universitario Marqués de Valdecilla | — |
| Unknown | Physiological and Environmental Data in a Remote Setting to Predict Exacerbation Events in Patients With Chron NCT06118632 | Chelsea and Westminster NHS Foundation Trust | — |
| Recruiting | Telehealth and Onsite Maintenance Exercise in Chronic Lung Disease NCT06304207 | MGH Institute of Health Professions | N/A |
| Recruiting | Predicting Adverse Outcomes Using Machine Learning of COPD Patients in Hong Kong NCT05825014 | Chinese University of Hong Kong | — |
| Recruiting | DUET Versus Standard Interface for Hypercapnic COPD Patients NCT05829083 | Larissa University Hospital | N/A |
| Completed | Comparison of Multiple Oxygenation Targets With Different Oximeters in Chronic Obstructive Pulmonary Disease ( NCT05819164 | Laval University | N/A |
| Recruiting | Non-contact Proactive Remote Monitoring of COPD Exacerbations NCT05598983 | Life Detection Technologies | — |
| Unknown | Clinical Study for the Effectiveness of Roflumilast Treatment in COPD Greek Patients Based on Standard Clinica NCT05426915 | Elpen Pharmaceutical Co. Inc. | — |
| Unknown | Exploring Clinical Predictors of COPD Exacerbation in a Community Cohort NCT05762861 | University of Minho | N/A |
| Unknown | The Addition of Inhaled Furosemide to Standard Treatment of COPD Exacerbation NCT05769738 | American University of Beirut Medical Center | Phase 3 |
| Unknown | Multi-omics Studies of Host-microbiome Interaction in Chronic Obstructive Pulmonary Disease and Bronchiectasis NCT05738044 | Ruijin Hospital | — |
| Unknown | Effect of Noninvasive High Frequency Oscillatory Ventilation on Improving CO2 Clearance in COPD Patients NCT05721833 | Guangzhou Institute of Respiratory Disease | N/A |
| Terminated | Early Extubation by ECCO2R Compared to IMV in Patients with Severe Acute Exacerbation of COPD NCT03584295 | Xenios AG | N/A |
| Recruiting | Effect of Home Based Pulmonary Rehabilitation on Exacerbation and Hospital Admission in Severe COPD NCT05738720 | Saglik Bilimleri Universitesi | N/A |
| Unknown | Risk Stratifying COPD Exacerbations NCT05852327 | Pamela Youde Nethersole Eastern Hospital | — |
| Completed | Once Daily Long-Acting Muscarinic Antagonists Administered in the Evening for Prevention of Chronic Obstructiv NCT05563675 | Chronic Obstructive Pulmonary Disease Trial Network, Denmark | Phase 4 |
| Enrolling By Invitation | Advancing Health Information Exchange (HIE) During Inter-hospital Transfer (IHT) to Improve Patient Outcomes NCT05443321 | Brigham and Women's Hospital | N/A |
| Recruiting | Effects of Blocking TSLP on Airway Inflammation and the Epithelial Immune-response to Exacerbation Triggers in NCT05507242 | Asger Sverrild | Phase 2 |
| Recruiting | Patients With Severe Acute Exacerbation of COPD Ans Admitted in ICU Register. NCT06257329 | Alexis FERRE | — |
| Completed | Study to Identify the Reduction of Exacerbations Resulting in Hospital Admission in Patients With COPD. NCT05440188 | Universidad Autonoma de Madrid | — |
| Unknown | Evaluation of Home-based Sensor System to Detect Health Decompensation in Elderly Patients With History of CHF NCT05865184 | Sensorum Health Inc. | — |
| Completed | Healthy At Home Pilot NCT06000696 | University of Massachusetts, Worcester | — |
| Completed | Pulmonary Rehabilitation for COPD Patients: Can Performance Predict Exacerbation? NCT05492149 | Groupe Hospitalier du Havre | — |
| Unknown | Evaluation of the Efficacy of Different Nebulization Techniques NCT05507060 | Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey | N/A |
| Unknown | Effect of Cough Assist Device in COPD Patients Admitted to Respiratory Intensive Care Unit at Assiut Universit NCT05491408 | Assiut University | — |
| Unknown | Markers of COPD Exacerbations NCT05315674 | Center of Expertise for Chronic Organ Failure | — |
| Unknown | Performance of Novel Bed Side Scores as Predictors of Hospital Outcome in Acute Exacerbation of Chronic Obstru NCT05370664 | Assiut University | — |
| Recruiting | Virtual Reality in COPD Exacerbation NCT05687396 | Pamukkale University | N/A |
| Completed | Cough Monitoring in COPD NCT07098793 | Hull University Teaching Hospitals NHS Trust | — |
| Completed | A Study Comparing Efficacy, Safety and Tolerability of the Fixed Dose Triple Combination CHF 5993 With the Fix NCT04320342 | Chiesi Farmaceutici S.p.A. | Phase 3 |
| Completed | Use of ΔIVC for Early Diagnosis of AHF in AECOPD NCT05327374 | University of Monastir | — |
| Terminated | Clinical Feasibility of a Non-invasive Wearable Acoustic Device for Measuring Air Trapping in COPD NCT04450368 | Respira Labs, Inc | — |
| Unknown | Inhaled Amikacin in Preventing AECOPD NCT05213507 | Shanghai Zhongshan Hospital | Phase 3 |
| Unknown | Short-course Antibiotic Treatment in AECOPD: a Meta-analysis of Double-blind Studies NCT05380375 | University of Monastir | — |
| Recruiting | Atorvastatin Effect on Reduction of COPD Exacerbations NCT04789057 | Medical University of Bialystok | Phase 4 |
| Completed | Enhancing Muscle Function After Exacerbations of COPD to Limit Its Impact on Physical Activity Decline NCT05233137 | KU Leuven | N/A |
| Completed | Use of PARniv for Early Diagnosis of LVF in AECOPD NCT05189119 | University of Monastir | — |
| Unknown | Eosinophil-driven Corticotherapy for Patients Hospitalized for COPD Exacerbation NCT04234360 | University Hospital, Montpellier | Phase 3 |
| Completed | Testing a Prediction Algorithm Into a Running Telehealth System for Patients With COPD NCT05218525 | Aalborg University | N/A |
| Recruiting | Multidisciplinary Management of Severe COPD NCT04860375 | Vastra Gotaland Region | N/A |
| Completed | The Effect of Incentive Spirometry Added to Routine Physiotherapy Program on Hemodynamic Responses and Hospita NCT04170361 | Bezmialem Vakif University | N/A |
| Unknown | FreeO2 PreHospital - Automated Oxygen Titration vs Manual Titration According to the BLS-PCS NCT03696563 | François Lellouche | N/A |
| Unknown | PCT-guided Treatment Regarding Antibiotic Use for Acute COPD Exacerbations NCT05854901 | Erasmus Medical Center | N/A |
| Unknown | Drivers of Eosinophilic COPD Exacerbations NCT04961060 | University Medical Center Groningen | — |
| Completed | Eosinophil-guided Reduction of Inhaled Corticosteroids NCT04481555 | Chronic Obstructive Pulmonary Disease Trial Network, Denmark | Phase 4 |
| Completed | Effectiveness of Low-Dose Theophylline for the Management of Biomass-Associated COPD NCT03984188 | University of Miami | Phase 3 |
| Completed | Study of Physiological Signals During and After COPD Exacerbations NCT04034901 | Biosency | N/A |
| Unknown | Non-inferiority Evaluation of Trimbow in Critically Ill Patients Admitted in ICU Compared to Standard of Care NCT04737655 | PARZIBUT Gilles | Phase 4 |
| Unknown | Chronic Obstructive Pulmonary Disease (COPD) Monitoring NCT04671888 | Medtronic BRC | N/A |
| Terminated | AIRVO Device Intervention for Moderate to Severe COPD NCT04576936 | Renown Health | N/A |
| Unknown | A Multi-center Study to Determine the Prevalence and Influence of Pertussis on COPD Exacerbation in Shenzhen NCT04694430 | Shenzhen People's Hospital | — |
| Unknown | Feasibility, Safety and Efficacy of Nebulized Long-Acting Bronchodilators (Formoterol and Revefenacin) vs. Sho NCT04655170 | University of Tennessee Graduate School of Medicine | Phase 4 |
| Completed | Increasing Adherence to Pulmonary Rehabilitation After COPD Related Hospitalizations (Study 2) NCT04521608 | Mayo Clinic | N/A |
| Completed | Molecular Breath Print of COPD Patients With Exacerbations Despite Triple Inhalational Therapy NCT04638920 | Malcolm Kohler | — |
| Completed | A Feasibility Study of Wearable Device in Assessing Respiratory Condition Change of Patients With Exacerbation NCT05153122 | NanoVation | N/A |
| Unknown | Mitoquines in COPD NCT04449419 | Hospital Universitario Marqués de Valdecilla | — |
| Completed | Development and Evaluation of Clinical Pharmacy Services in Respiratory Diseases NCT05564156 | Bezmialem Vakif University | N/A |
| Terminated | The Effects of Enoximone in Acute Exacerbation COPD NCT04420455 | Rijnstate Hospital | Phase 4 |
| Unknown | COPD in the Time of COVID-19 NCT04407598 | University of Leicester | — |
| Active Not Recruiting | Predictors of Acute Exacerbation in Patients With COPD - an Observational Study NCT04140097 | Schön Klinik Berchtesgadener Land | — |
| Terminated | Comparing Mortality for Low vs High Peripheral Oxygen Saturation in COPD-patients With Acute Exacerbation NCT04223050 | Esbjerg Hospital - University Hospital of Southern Denmark | Phase 4 |
| Terminated | Effects of High Flow Nasal Cannula on Sputum Clearance in Acute Exacerbation of Chronic Obstructive Pulmonary NCT04217746 | Tufts Medical Center | N/A |
| Unknown | Physical Activity Barriers in AECOPD NCT04162392 | Universidad de Granada | N/A |
| Unknown | Physiotherapy in Hypoxic AECOPD Patients NCT04295655 | Universidad de Granada | N/A |
| Terminated | COPD Exacerbation Alert System With urinE anaLysis Using the HEADSTART Device NCT04296318 | Mologic Ltd | — |
| Recruiting | Influence of FreeO2 on Percentage of Time Within Oxygen Saturation Target Using Noninvasive Ventilation (NIV) NCT04136717 | François Lellouche | N/A |
| Unknown | Breath-actuated Nebulizers in Acute COPD Exacerbations NCT03985748 | Rhode Island Hospital | N/A |
| Completed | Weight Training With VR in Out-Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease NCT04880486 | National Cheng-Kung University Hospital | N/A |
| Unknown | The Effect of Long Term Therapy With High Flow Humidification Compared to Usual Care in Patients With Bronchie NCT04142827 | Dr. Giuseppe Fiorentino | N/A |
| Unknown | Predictability of Echographic Excursion of the Diaphragm for Intubation in COPD- Patients With Acute Respirato NCT04591509 | European Georges Pompidou Hospital | — |
| Recruiting | Respiratory Support in Chronic Obstructive Pulmonary Disease (COPD) Patients NCT03890224 | Clinact | N/A |
| Completed | Nurse-led Integrated Care in COPD Patients With a Pulmonary Exacerbation NCT04011332 | University of Zurich | N/A |
| Unknown | Borg Score Outcomes in Respiratory Compromised Acute Exacerbating Chronic Obstructive Pulmonary Disease (COPD) NCT04181073 | NHS Greater Clyde and Glasgow | N/A |
| Terminated | Health Literacy Activation RCT Among the COPD Patients and Designated Support Dyad NCT03721315 | Albert Einstein Healthcare Network | N/A |
| Unknown | Mechanisms of COPD Exacerbation Recurrence NCT04024735 | University College, London | — |
| Completed | A Retrospective rEal-life daTa Study to Assess the exaceRbations and Lung functIon in Chronic Obstructive Pulm NCT03858348 | Elpen Pharmaceutical Co. Inc. | — |
| Unknown | Isolation of Circulating Pulmonary Cells in COPD and Its Relationship With Clinical Relevant Outcomes (IbICEnC NCT03591978 | Universidad de Granada | — |
| Unknown | Evaluation of Eosinophil Phenotype in COPD Patients NCT04494308 | IRCCS San Raffaele Roma | — |
| Unknown | Heated High Humidity After COPD Exacerbation NCT03772626 | McMaster University | N/A |
| Recruiting | Mast Cells and Its Proteases in COPD NCT06392334 | Voronezh N.N. Burdenko State Medical Academy | N/A |
| Unknown | Telemonitoring System for Early Diagnosis of COPD Exacerbations. NCT03739957 | Laboratori di Informatica Applicata | N/A |
| Unknown | Evaluation of the Multidimensional Dyspnea Profile (MDP) NCT04090671 | Institut für Pneumologie Hagen Ambrock eV | N/A |
| Completed | A Cross Sectional, Diagnostic Accuracy Study to Validate the Use of a New Device(Inflammacheck™) in Diagnosing NCT04024657 | Portsmouth Hospitals NHS Trust | — |
| Terminated | Automated Adjustment of Oxygen on Patient With Acute COPD Exacerbation - FreeO2 HypHop NCT03835741 | Laval University | N/A |
| Completed | Oxygen Control and Weaning by O2matic to Patients Admitted With an Exacerbation of COPD NCT03661086 | Hvidovre University Hospital | N/A |
| Completed | Anti-ST2 (MSTT1041A) in COPD (COPD-ST2OP) NCT03615040 | University of Leicester | Phase 2 |
| Recruiting | Nasal High-Flow in COPD NCT03564236 | Marieke Duiverman | N/A |
| Unknown | Pulmonary Rehabilitation Innovation and Microbiota in Exacerbations of COPD NCT03701945 | Aveiro University | N/A |
| Unknown | Pattern of Admitted Cases in Respiratory Intensive Care Unit at Assiut University Hospitals NCT03296215 | Assiut University | — |
| Completed | Nurse-led COPD Self-management Intervention NCT04459546 | Pamukkale University | N/A |
| Completed | HFNC and Acute Hypercapnic Respiratory Failure NCT04109560 | Argentinian Intensive Care Society | — |
| Unknown | The Role of Congenital Mucosal Immune System in the Airways of Patients With Chronic Obstructive Pulmonary Dis NCT04061122 | Medical University of Lodz | — |
| Recruiting | FreeDom: Innovative Strategy for the Management of COPD Exacerbations NCT03396172 | Laval University | N/A |
| Completed | Automated Oxygen Delivery by O2matic to Patients Admitted With an Exacerbation in COPD NCT03464695 | Hvidovre University Hospital | N/A |
| Completed | HOT HMV 2: A Phase 4 Study NCT04272879 | Guy's and St Thomas' NHS Foundation Trust | — |
| Completed | Biomarker of Acute Exacerbation of COPD NCT04963244 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Terminated | Sevoflurane in Chronic Obstructive Pulmonary Disease Exacerbation NCT03460015 | University Hospital, Montpellier | N/A |
| Completed | High Flow Nasal Therapy Versus Noninvasive Ventilation in COPD Exacerbation NCT03370666 | Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo | N/A |
| Completed | Study to Explore the Relationship Between the Level of Exhaled Breath Condensate Hydrogen Peroxide (EBC H2O2) NCT04061291 | Portsmouth Hospitals NHS Trust | — |
| Completed | The Impact of Sarcopenia on COPD Exacerbation Admission Outcome and Further Exacerbation Risk NCT04885933 | Far Eastern Memorial Hospital | — |
| Completed | Increasing Adherence to Pulmonary Rehabilitation After COPD Related Hospitalizations (Pilot Study) NCT03865329 | Mayo Clinic | N/A |
| Completed | Acupuncture Treatment of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation NCT03398213 | Bnai Zion Medical Center | N/A |
| Completed | COPD Care Model on Clinical and Patient-Reported Outcomes NCT03332394 | Ottawa Hospital Research Institute | — |
| Completed | mRNA and miRNA Airway Inflammatory Markers NCT03924843 | University Medical Center Groningen | — |
| Unknown | Physical Activity in Chronic Obstructive Pulmonary Disease(COPD) Acute Exacerbation Patients NCT03437252 | Samsung Medical Center | — |
| Completed | Stratified TreAtment to Reduce Risk in COPD NCT04458636 | University of Oxford | Phase 4 |
| Completed | iVAPS vs. S/T Modes as Non-invasive Weaning Strategy in COPD Patients NCT03222271 | Assiut University | N/A |
| Completed | Effectiveness of Vibrating Mesh Versus Small Volume Nebuliser in Chronic Obstructive Pulmonary Disease (COPD) NCT03286855 | Beaumont Hospital | N/A |
| Terminated | Nebulizer Versus Dry Powdered Inhalers for Chronic Obstructive Pulmonary Disease (COPD) NCT03219866 | Wake Forest University Health Sciences | Phase 4 |
| Completed | Prevalence, Associated Factors Points and Implementation of Care Procedures of Chronic Obstructive Pulmonary D NCT05682404 | University Hospital, Grenoble | — |
| Completed | Outgoing Lung Team - a Cross-sectorial Intervention in Patients With COPD NCT04119856 | University of Aarhus | N/A |
| Unknown | Palliative Outcome Evaluation Muenster I NCT03286127 | University Hospital Muenster | — |
| Unknown | Changes in Microcirculation and Functional Status During Exacerbation of COPD NCT03250000 | Hasselt University | — |
| Completed | Effect of High Flow Nasal During Exercise in COPD Patients NCT03058081 | Groupe Hospitalier du Havre | N/A |
| Unknown | Steroid Resistance During COPD Exacerbations With Respiratory Failure NCT03680495 | University of Colorado, Denver | — |
| Unknown | The Appropriate Anticoagulation Duration for Chronic Obstructive Pulmonary Disease With Pulmonary Thromboembol NCT03185845 | Chinese Academy of Medical Sciences, Fuwai Hospital | N/A |
| Completed | Telehealth Pulmonary Rehabilitation for Hispanic and African-American Patients Admitted With Exacerbation of C NCT03007485 | Northwell Health | N/A |
| Completed | Salvational Intervention for Reducing AECOPD Under Severe Air Pollution NCT03083067 | Peking University First Hospital | N/A |
| Completed | Clinical Evaluation of FreeO2 (Version 4) in All Patients Receiving Oxygen NCT03119727 | Laval University | N/A |
| Completed | Influence of Respiratory Mechanics on Diaphragmatic Dysfunction in COPD Patients Who Have Failed NIV (RHYDIAN) NCT03852394 | University of Modena and Reggio Emilia | — |
| Unknown | High Flow Nasal Cannula vs NPPV in Moderate Chronic Obstructive Pulmonary Disease Exacerbation NCT03014869 | China-Japan Friendship Hospital | N/A |
| Unknown | Respiratory Support in Severe Chronic Obstructive Pulmonary Disease Exacerbation NCT03020394 | China-Japan Friendship Hospital | — |
| Unknown | HFNC vs Nasal Cannula in Mild Chronic Obstructive Pulmonary Disease Exacerbation NCT03003559 | China-Japan Friendship Hospital | N/A |
| Unknown | Extracorporeal Carbon Dioxide Removal in Severe Chronic Obstructive Pulmonary Disease Exacerbation NCT03692117 | China-Japan Friendship Hospital | — |
| Terminated | Palliation of Dyspnea With Mouth Piece Ventilation in AECOPD NCT03025425 | Tampere University Hospital | N/A |
| Unknown | Platelet Activation and Reactivity in Acute Exacerbations of COPD NCT03017625 | Radboud University Medical Center | — |
| Completed | Change in Breathing Pattern on Non-invasive Ventilation of COPD Patients Under Home Mechanical Ventilation NCT03018470 | University Hospital, Rouen | — |
| Completed | Phenotypic Measurements and Their Relation to Disease Exacerbation in COPD Patients NCT03300739 | Massachusetts General Hospital | — |
| Unknown | Structured Discharge and Follow-up Protocol for COPD Patients Receiving LTOT and NIV NCT03499470 | Dokuz Eylul University | N/A |
| Completed | Shared Decision Making in Hospitalized AECOPD NCT03772639 | Universidad de Granada | N/A |
| Completed | Domiciliary Monitoring to Predict Exacerbations of COPD NCT03003702 | University College, London | N/A |
| Completed | NIV - NAVA vs NIV - PS for COPD Exacerbation NCT02912689 | All India Institute of Medical Sciences | N/A |
| Unknown | Innate Immunity in Ozone-induced Airway Inflammation in COPD NCT04669743 | University of California, San Francisco | N/A |
| Completed | nCD64 vs. Neutrophil/Lymphocyte Ratio for Predicting In-hospital Outcome in AE-COPD NCT03146611 | Assiut University | — |
| Completed | The Oral Microbiota as Reservoir for Systemic Opportunistic Pathogens NCT02619903 | Malmö University | N/A |
| Completed | Project to Improve the Diagnosis and Treatment Ability of Adult Severe Community Acquired Lower Respiratory Tr NCT04959955 | Peking University Third Hospital | — |
| Completed | Comparison of High-flow Oxygen vs. BiPAP in Type II (Hypercapnic) Respiratory Failure NCT03443479 | Hôpital de Verdun | — |
| Unknown | High Flow Oxygen Therapy in Patients Suffering From Chronic Obstructive Pulmonary Disease Exacerbation: Effect NCT02371564 | University Hospital, Angers | N/A |
| Completed | COPD Aerosol Study Comparing the Efficacy of Nebulizers Versus Dry Powder Inhalers NCT02291016 | University of Tennessee Graduate School of Medicine | N/A |
| Withdrawn | Evaluation of Lung Doppler Signals in Patients Presenting to EMD NCT01961141 | Echosense Ltd. | — |
| Unknown | Low-dose CT for Diagnosis of Pneumonia in COPD Exacerbations and Comparison of the Inflammatory Profile. NCT02264483 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | — |
| Completed | Using Mobile Health to Respond Early to Acute Exacerbations of COPD in HIV NCT01892566 | Johns Hopkins Bloomberg School of Public Health | N/A |
| Completed | Comparative Effectiveness of Symbicort vs. Spiriva Among COPD Patients NCT01917643 | AstraZeneca | — |
| Completed | Effects of Physical Activity Counseling After an Exacerbation in COPD NCT02223962 | KU Leuven | N/A |
| Completed | Efficacy of Varenicline on Smoking Cessation at the Acute Phase of an Exacerbation of Chronic Obstructive Pulm NCT01694732 | University Hospital, Brest | Phase 3 |
| Completed | Early Assisted Discharge for COPD Exacerbations With Telemonitoring. NCT01951261 | Dr. López Viña | N/A |
| Completed | Comparison of Two Ventilator Mode During the Night: New Strategy of Mechanical Ventilation Weaning NCT01573481 | Centre Hospitalier Universitaire, Amiens | N/A |
| Completed | Cough Frequency in Chronic Obstructive Pulmonary Disease NCT01405222 | Hull University Teaching Hospitals NHS Trust | — |
| Completed | Ceftidoren Versus Levofloxacin in the Treatment of Patients With Acute Exacerbations of Chronic Bronchitis (AE NCT01467297 | University of Milan | Phase 4 |
| Completed | Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Dose Combinations of L NCT01443845 | AstraZeneca | Phase 4 |
| Unknown | Using a Closed-loop System for Oxygen Delivery (FreeO2) to Optimize Oxygentherapy in Patients With COPD Exacer NCT01393015 | Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec | N/A |
| Completed | Extracorporeal CO2 Removal in COPD Exacerbation NCT01422681 | University of Turin, Italy | Phase 2 |
| Completed | Valsalva Manœuvre in the Diagnosis of Left Ventricular Failure in Chronic Obstructive Pulmonary Disease Exacer NCT01619540 | University of Monastir | N/A |
| Unknown | Evaluation of Utility Quadriceps Magnetic Stimulation in COPD (Chronic Obstructive Pulmonary Disease) Patients NCT01264978 | Hospital de Cruces | Phase 3 |
| Completed | Oral Prednisolone in Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) NCT01353235 | Fekri Abroug | Phase 3 |
| Completed | Comparison Between Levofloxacin and Prulifloxacin, in Internal Medicine Patients With Acute Exacerbation of CO NCT01710488 | Fadoi Foundation, Italy | Phase 4 |
| Completed | TNF-alpha Antagonists for AECOPD: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial NCT00789997 | Ottawa Hospital Research Institute | Phase 2 / Phase 3 |
| Completed | Chronic Obstructive Pulmonary Disease: CT Features of Severe Exacerbation NCT01922180 | Erasme University Hospital | — |
| Unknown | Swiss Chronic Obstructive Pulmonary Disease (COPD) Management Cohort NCT02065921 | Prof. Dr. Jörg Leuppi | — |
| Completed | Magnesium Sulfate Versus Ipratropuim Bromide in Acute Exacerbation of Chronic Obstructive Pulmonary Disease NCT01136421 | University of Monastir | Phase 3 |
| Completed | Hospitalization at Home of Elderly Patients With Exacerbated COPD NCT00369083 | Azienda Ospedaliera San Giovanni Battista | N/A |