NCT04694430

A Multi-center Study to Determine the Prevalence and Influence of Pertussis on COPD Exacerbation in Shenzhen

A Integration of Respiratory Medicine and Prevention Multi-center Study to Determine the Prevalence and Influence of Pertussis on Chronic Obstructive Pulmonary Disease Exacerbation in Shenzhen by National Respiratory Diseases Clinical Medicine Research Center

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: Shenzhen People's Hospital · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

A prospective, multi-center, observational clinical trail. Aim to evaluate the real incidence of chronic obstructive pulmonary disease (COPD) pertussis and the impact of pertussis on COPD exacerbation.

Detailed description

1. Investigate the incidence and epidemiological characteristics of pertussis infection in COPD population. 2. To explore the relationship between pertussis infection and COPD exacerbation.

Conditions

• COPD Exacerbation
• Pertussis

Interventions

Type	Name	Description
PROCEDURE	Blood sample	2 ml venous blood was collected and separated into serum.
OTHER	Data collection	1. Whether the patient has been vaccinated with DPT vaccine and record the time of vaccination; 2. Medication situation of patients in the past year, including rescue drugs, antitussive and expectorant drugs, inhaled corticosteroids and antibiotics; 3. Assess COPD using ABCD assessment tool.
PROCEDURE	Throat swab	Before the collection of oropharyngeal swabs, instruct the patient to wash the mouth or gargle, fix the patient's head, open the mouth and expose the throat. If necessary, use a tongue depressor to gently press the tongue. Use the swab to wipe the secretion on both sides of the palatal arch, pharynx and tonsil with a sensitive and gentle action, and quickly withdraw the swab to avoid contacting other parts of the mouth. Put the swab in the sterile test tube, plug the opening with cotton ball, and send it for inspection and registration in time.

Timeline

• Start date: 2021-01-01
• Primary completion: 2021-06-30
• Completion: 2021-12-31
• First posted: 2021-01-05
• Last updated: 2021-01-05

Locations

27 sites across 1 country: China