Clinical Trials Directory

Trials / Completed

CompletedNCT03443479

Comparison of High-flow Oxygen vs. BiPAP in Type II (Hypercapnic) Respiratory Failure

Retrospective Cohort Study of Patients With Type II (Hypercapnic) Respiratory Failure Treated With High-flow Oxygen Therapy Versus Non-invasive Ventilation With BiPAP

Status
Completed
Phase
—
Study type
Observational
Enrollment
324 (actual)
Sponsor
Hôpital de Verdun · Academic / Other
Sex
All
Age
18 Years
Healthy volunteers
Not accepted

Summary

A retrospective cohort study of all patients treated for type II (hypercapnic) respiratory failure with either High-Flow Oxygen Therapy or Non-Invasive Ventilation in a general adult hospital.

Detailed description

We will compare various clinically relevant outcomes in patients treated for type II (hypercapnic) acute respiratory failure (ARF) with either High-Flow Nasal Cannula (HFNC) or Non-Invasive Ventilation (NIV) in a general adult hospital. All patients treated with HFNC were treated with an Optiflow device (Fisher\&Paykel). Various Bilevel positive airway pressure (BiPAP) devices were used during the study period. All ventilatory parameters were set according to the treating physicians' preferences.

Conditions

Interventions

TypeNameDescription
DEVICENon-Invasive VentilationTreatment with Non-Invasive Ventilation by BiPAP. Different BiPAP models are in use. Ventilation parameters set at the discretion of the treating physician.
DEVICEHigh-Flow Nasal CannulaTreatment with a High-Flow Nasal Cannula. The Optiflow device by Fisher\&Paykel used in all cases. Flow and fraction of inspired oxygen (FiO2) parameters at the discretion of the treating physician.

Timeline

Start date
2015-04-01
Primary completion
2019-07-01
Completion
2019-07-01
First posted
2018-02-23
Last updated
2020-07-28

Locations

1 site across 1 country: Canada

Regulatory

Source: ClinicalTrials.gov record NCT03443479. Inclusion in this directory is not an endorsement.