Trials / Unknown
UnknownNCT04061122
The Role of Congenital Mucosal Immune System in the Airways of Patients With Chronic Obstructive Pulmonary Disease
The Role of Congenital Mucosal Immune System in the Airways of Patients With COPD
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 40 (estimated)
- Sponsor
- Medical University of Lodz · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
The purpose of the study is to explore the role of congenital mucosal immune system in the airways of patients with COPD including the impact of ILCs (Innate lymphoid cells) on metabolism of epithelial cells.During the research the following methods will be applied: measurement of Volatile Organic Compounds (VOCS), airway epithelial cytology and culture.
Detailed description
ILCs profiles, epithelium metabolism measured by VOCS and microbiome profiling (specific 16S rRNA-16S ribosomal RNA gene-targeted qPCR) will by determined in the airways of patients with COPD after the exacerbation. Microbiome profiling will be based on next generation sequencing (NGS) of the 16S rRNA encoding region.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | airway epithelial smear test | all patients will be subjected to all scheduled procedures: airways epithelial smear test, measurement of VOCs in exhaled air and airways slide sample culture |
Timeline
- Start date
- 2018-07-04
- Primary completion
- 2020-01-30
- Completion
- 2020-06-30
- First posted
- 2019-08-19
- Last updated
- 2019-08-19
Locations
1 site across 1 country: Poland
Source: ClinicalTrials.gov record NCT04061122. Inclusion in this directory is not an endorsement.