| Not Yet Recruiting | Evaluation of Skin Tests in Biotherapy Allergies NCT06971848 | University Hospital, Angers | N/A |
| Recruiting | Measurement of MMP-14 Protein, a Potential New Marker for Colorectal Cancer Detection, in Plasma Vesicles Name NCT06955767 | CHU de Reims | N/A |
| Recruiting | A Feasibility Study of Mass-Based Response Drug Screening to Guide Personalized Hyperthermic Intraperitoneal C NCT07291180 | Yale University | N/A |
| Not Yet Recruiting | Study Comparing the Quality of Colon Cleanliness With Prepackaged LRD (Low-residue Diet) vs. Guided (POG). NCT07361575 | Clinique Paris-Bercy | N/A |
| Not Yet Recruiting | Family Communications After Genetic Testing NCT07143487 | Alliance for Clinical Trials in Oncology | N/A |
| Recruiting | Upfront Trastuzumab-Deruxtecan Plus Capecitabine and Bevacizumab for Patients With HER-2 Positive Metastatic C NCT07407465 | Gruppo Oncologico del Nord-Ovest | Phase 2 |
| Not Yet Recruiting | Evaluation of Tumor Budding In Colorectal Adenocarcinoma NCT07003776 | Sohag University | — |
| Recruiting | A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors NCT07020117 | Aktis Oncology, Inc. | Phase 1 |
| Recruiting | AK112 and Chemotherapy in First-line Metastatic Colorectal Cancer NCT06951503 | Akeso | Phase 3 |
| Recruiting | A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With S NCT06682793 | A2 Biotherapeutics Inc. | Phase 1 / Phase 2 |
| Recruiting | AK129 Combination Therapy for Advanced Solid Tumors NCT06943820 | Akeso | Phase 1 / Phase 2 |
| Recruiting | Fluoxetine for the Modification of Colorectal Tumor Immune Cells Before Surgery in Patients With Colorectal Ca NCT06225011 | Jonsson Comprehensive Cancer Center | Phase 1 |
| Recruiting | A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation NCT06778863 | Clasp Therapeutics, Inc. | Phase 1 |
| Not Yet Recruiting | Robotic Right Hemicolectomy Versus Laparoscopic Right Hemicolectomy NCT06067620 | Jeremy Meyer | N/A |
| Recruiting | Encorafenib + Cetuximab Beyond Progression in Combination With FOLFIRI in Patients With BRAF V600E Mutated Met NCT06640166 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Phase 2 |
| Enrolling By Invitation | The Effect of Minimally Invasive Surgery on Systemic Inflammatory Response in Rectal Cancer NCT06540027 | Başakşehir Çam & Sakura City Hospital | — |
| Recruiting | A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With So NCT06051695 | A2 Biotherapeutics Inc. | Phase 1 / Phase 2 |
| Recruiting | A Randomized, Multicenter Phase II Basket Study of Hypofractionated Radiotherapy/Stereotactic Body Radiotherap NCT06349044 | Zhejiang Cancer Hospital | N/A |
| Terminated | ImmunoNutrition and Colorectal Adenocarcinoma Surgery - INCAS Study NCT06134440 | Istituto Oncologico Veneto IRCCS | N/A |
| Not Yet Recruiting | Chemotherapy Sequential Tislelizumab After Radical Resection in Patients With dMMR/MSI-H or POLE/POLD1 Mutatio NCT06118658 | China Medical University, China | Phase 2 |
| Recruiting | Factors Affecting the Results of Treatment of Patients With Colorectal Cancer NCT06050447 | Immanuel Kant Baltic Federal University | — |
| Recruiting | Performance and Safety of MiWEndo-assisted Colonoscopy (MiWEndo II) NCT05988645 | MiWEndo Solutions S.L. | N/A |
| Recruiting | DANISH.MRD: Danish Assessment of Minimal Residual Disease by Liquid Biopsies NCT06076811 | University of Aarhus | — |
| Withdrawn | Vaccine Response With NT-I7 NCT04054752 | National Cancer Institute (NCI) | Phase 1 |
| Active Not Recruiting | A Study to Evaluate the Safety and Efficacy of A2B530, a Logic-gated CAR T, in Participants With Solid Tumors NCT05736731 | A2 Biotherapeutics Inc. | Phase 1 / Phase 2 |
| Terminated | A Study of NUC-3373 in Combination With Other Agents in Patients With Colorectal Cancer NCT05678257 | NuCana plc | Phase 2 |
| Recruiting | Early Onset Colorectal Cancer Detection NCT06342401 | City of Hope Medical Center | — |
| Completed | Early-Onset Colorectal Cancer Recurrence NCT06271980 | City of Hope Medical Center | — |
| Completed | Predicting Local and Distant Recurrence in T1 Colorectal Cancer NCT06314971 | City of Hope Medical Center | — |
| Recruiting | Stage II/III Colorectal Cancer Recurrence NCT06314958 | City of Hope Medical Center | — |
| Active Not Recruiting | A First-in-Human, Phase 1 Study of TST003 in Subjects With Solid Tumors NCT05731271 | Suzhou Transcenta Therapeutics Co., Ltd. | Phase 1 / Phase 2 |
| Unknown | Analysis of Histopathological Factors Predictive of Lymph Node Involvement and Management Practices in pT1 Col NCT06339346 | University Hospital, Brest | — |
| Completed | Feasibility and Safety of MiWEndo-assisted Colonoscopy NCT05477836 | MiWEndo Solutions S.L. | N/A |
| Active Not Recruiting | Study of JK08 in Patients with Unresectable Locally Advanced or Metastatic Cancer NCT05620134 | Salubris Biotherapeutics Inc | Phase 1 / Phase 2 |
| Active Not Recruiting | METIMMOX-2: Metastatic pMMR/MSS Colorectal Cancer - Shaping Anti-Tumor Immunity by Oxaliplatin NCT05504252 | University Hospital, Akershus | Phase 2 |
| Completed | Phase 2 Study of DKN-01 in Colorectal Cancer NCT05480306 | Leap Therapeutics, Inc. | Phase 2 |
| Recruiting | A Study of VS-6766 and Cetuximab in Patients With Advanced Colorectal Cancer NCT05200442 | University of Chicago | Phase 1 / Phase 2 |
| Unknown | Early Detection of Cancer Onset Based on Sensing Field Cancerization at the Organ Level in the Alimentary Trac NCT05247346 | University Medical Center Groningen | N/A |
| Completed | Treatment of Cabotamig (ARB202) in Advanced Gastrointestinal Cancer Patients NCT05411133 | Arbele Pty Ltd | Phase 1 |
| Terminated | Cardiovascular Events From Trifluridine/Tipiracil +/- Oxaliplatin in Colorectal/Oesogastric Adenocarcinoma Pat NCT04894123 | GERCOR - Multidisciplinary Oncology Cooperative Group | Phase 2 |
| Unknown | Predictive Factors for Outcomes of Fruquintinib Plus Immunotherapy in Colorectal Cancer NCT05635149 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | — |
| Active Not Recruiting | Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer NCT04963283 | University of Colorado, Denver | Phase 2 |
| Active Not Recruiting | Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients with PD1-high MRNA Express NCT04802876 | SOLTI Breast Cancer Research Group | Phase 2 |
| Completed | A Study of CM24 in Combination with Nivolumab in Adults with Advanced Solid Tumors NCT04731467 | Famewave Ltd. | Phase 1 / Phase 2 |
| Completed | Feasibility Study of a 4 Stage Bowel Obstruction Cancer Diet NCT04898842 | Royal Surrey County Hospital NHS Foundation Trust | N/A |
| Active Not Recruiting | Temozolomide, Cisplatin, and Nivolumab in People With Colorectal Cancer NCT04457284 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Active Not Recruiting | A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma NCT04111172 | Thomas Jefferson University | Phase 2 |
| Terminated | Immunotherapy With Y90-RadioEmbolization for Metastatic Colorectal Cancer NCT04108481 | University of Iowa | Phase 1 |
| Unknown | Colorectal Metastasis and Liver Transplantation With Organs From Deceased Donors NCT04870879 | Azienda Ospedaliera di Padova | N/A |
| Completed | A Study to Evaluate NT219 Alone and in Combination with ERBITUX® (Cetuximab) in Adults with Advanced Solid Tum NCT04474470 | TyrNovo Ltd. | Phase 1 / Phase 2 |
| Unknown | To Compare Artificial Intelligence Software Aided Adenoma Detection in Screening Colonoscopies Versus Standard NCT04196088 | Docbot, Inc. | N/A |
| Unknown | A Phase I/II Study of XELOXIRI and Bevacizumab as First-line Treatment in Metastatic Colorectal Cancer NCT04380103 | Chinese Academy of Medical Sciences | Phase 1 / Phase 2 |
| Unknown | The Role of Quantitative Measures on Dual-energy CT in the Prediction of Colorectal Adenocarcinoma NCT04430127 | Hôpital Fribourgeois | — |
| Recruiting | Early Detection of Advanced Adenomas and Colorectal Cancer NCT06342440 | City of Hope Medical Center | — |
| Withdrawn | A Pilot Study to Explore the Role of Gut Flora in Colorectal Cancer NCT04148378 | ProgenaBiome | — |
| Withdrawn | Guadecitabine and Nivolumab in Treating Refractory Metastatic Colorectal Cancer NCT03576963 | University of Southern California | Phase 1 / Phase 2 |
| Recruiting | Minimal Residual Disease Assessment in Patients With Colorectal Cancer, the MiRDA-C Study NCT04739072 | M.D. Anderson Cancer Center | — |
| Active Not Recruiting | Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cance NCT04094688 | Alliance for Clinical Trials in Oncology | Phase 3 |
| Terminated | CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic Gastrointestinal Tumors NCT02757391 | M.D. Anderson Cancer Center | Phase 1 |
| Completed | Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chem NCT03366155 | National Cancer Institute (NCI) | Phase 2 |
| Terminated | Pilot Trial of Resistant Starch in Stage I-III Colorectal Cancer Survivors NCT03781778 | Fred Hutchinson Cancer Center | Phase 2 |
| Completed | The Problem of Colorectal Anastomosis Safety NCT03958500 | Vilnius University | N/A |
| Completed | Study of Nivolumab and Relatlimab in Patients With Microsatellite Stable (MSS) Advanced Colorectal Cancer NCT03642067 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Phase 2 |
| Completed | Nivolumab and Metformin in Patients With Treatment Refractory MSS Colorectal Cancer NCT03800602 | Emory University | Phase 2 |
| Unknown | Study of Guanábana Leaves for The Treatment of Patients With Gastric, Gastroesophageal Junction, Pancreatic an NCT04773769 | Auxilio Mutuo Cancer Center | N/A |
| Withdrawn | Bevacizumab Plus Capecitabin vs S-1 as Maintenance Treatment Following First-line Chemotherapy in the Patients NCT03708536 | Fujian Cancer Hospital | Phase 3 |
| Terminated | Durvalumab Plus CV301 With Maintenance Chemotherapy in Metastatic Colorectal or Pancreatic Adenocarcinoma NCT03376659 | Georgetown University | Phase 1 / Phase 2 |
| Active Not Recruiting | Chemotherapy and/or Metastasectomy in Treating Patients With Metastatic Colorectal Adenocarcinoma With Lung Me NCT03599752 | M.D. Anderson Cancer Center | Phase 2 |
| Unknown | Clinical Study of Personalized mRNA Vaccine Encoding Neoantigen in Patients With Advanced Digestive System Neo NCT03468244 | Changhai Hospital | N/A |
| Unknown | Endoscopic Full-Thickness Resection In Colon NCT03803891 | Fundació Institut Germans Trias i Pujol | — |
| Completed | Use of iFOBT in Patients Presenting With Alarm Symptoms of Colorectal Cancer NCT03367611 | University of Aarhus | N/A |
| Terminated | 5-FU Based Maintenance Therapy in RAS Wild Type Metastatic Colorectal Cancer After Induction With FOLFOX Plus NCT03300609 | University of Southern California | Phase 3 |
| Completed | Colvera for Detection of Disease Recurrence NCT03706235 | Clinical Genomics Pathology | — |
| Active Not Recruiting | TAS102 in Combination With NAL-IRI in Advanced GI Cancers NCT03368963 | Emory University | Phase 1 / Phase 2 |
| Completed | VX15/2503 and Immunotherapy in Resectable Pancreatic and Colorectal Cancer NCT03373188 | Emory University | Phase 1 |
| Completed | A Phase I/II Study of Pexa-Vec Oncolytic Virus in Combination With Immune Checkpoint Inhibition in Refractory NCT03206073 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Unknown | Very Low Carbohydrate Diet Effects to GPS, Serum Lactate and TNF Alpha on Colorectal Cancer NCT03221920 | Dr. Soetomo General Hospital | N/A |
| Completed | Pembrolizumab and XL888 in Patients With Advanced Gastrointestinal Cancer NCT03095781 | Emory University | Phase 1 |
| Unknown | Phase 1 Dose Escalation Study of CGX1321 in Subjects With Advanced Gastrointestinal Tumors NCT03507998 | Curegenix Inc. | Phase 1 |
| Completed | The Colorectal Breath Analysis (COBRA) Study NCT03699163 | Imperial College London | — |
| Active Not Recruiting | Perioperative Systemic Therapy for Isolated Resectable Colorectal Peritoneal Metastases NCT02758951 | Koen Rovers | Phase 2 / Phase 3 |
| Unknown | Exhaustive Genetic and Immunological Characterization of Colon, Kidney and Liver Tumors NCT03149523 | European Georges Pompidou Hospital | — |
| Terminated | Standard of Care Alone or in Combination With Ad-CEA Vaccine and Avelumab in People With Previously Untreated NCT03050814 | National Cancer Institute (NCI) | Phase 2 |
| Completed | PI Pembro in Combination With Stereotactic Body Radiotherapy for Liver Metastatic Colorectal Cancer NCT02837263 | University of Wisconsin, Madison | Phase 1 |
| Completed | Study of Nintedanib Plus Bevacizumab in Advanced Solid Tumors NCT02835833 | University of Alabama at Birmingham | Phase 1 |
| Terminated | TLR8 Agonist VTX-2337 and Cyclophosphamide in Treating Patients With Metastatic, Persistent, Recurrent, or Pro NCT02650635 | Mayo Clinic | Phase 1 |
| Unknown | Study of the Practice of Debiri in France NCT03369041 | Federation Francophone de Cancerologie Digestive | — |
| Terminated | Quinacrine-Capecitabine Combinatorial Therapy for Advanced Stage Colorectal Adenocarcinoma NCT01844076 | Fox Chase Cancer Center | Phase 1 / Phase 2 |
| Completed | Efficacy and the Safety of Regorafenib in Patients Aged More Than 70 Years With a Metastatic Colorectal Adenoc NCT02788006 | Federation Francophone de Cancerologie Digestive | Phase 2 |
| Terminated | Study of Oral Ceritinib in Patients With ALK and ROS1 Activated Gastrointestinal Malignancies NCT02638909 | Criterium, Inc. | Phase 2 |
| Withdrawn | Combination Chemotherapy and Bevacizumab With or Without PRI-724 in Treating Patients With Newly Diagnosed Met NCT02413853 | University of Southern California | Phase 2 |
| Completed | Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With RAS Wild-Type Locally Advanced NCT02292758 | Academic and Community Cancer Research United | Phase 2 |
| Completed | Oncological Impact of Lateral Nodes in Rectal Cancer NCT05592873 | Niguarda Hospital | — |
| Terminated | Surgery Plus Sulindac or Surgery Alone for Advanced Colorectal Cancer NCT01856322 | National Cancer Institute (NCI) | Phase 2 |
| Terminated | Safety and Feasibility of Electrochemotherapy in Unresectable Colorectal Adenocarninoma Liver Metastases NCT02709811 | IGEA | Phase 1 / Phase 2 |
| Unknown | Efficacy and Safety Study of a Modified XELOX Regimen in First-Line Treatment of Metastatic Colorectal Adenoca NCT01552967 | Sixth Affiliated Hospital, Sun Yat-sen University | Phase 2 |
| Terminated | Irinotecan Plus Brivanib in Metastatic Colorectal Cancer (CRC) Enriched for Elevated Levels of Plasma FGF NCT01367275 | M.D. Anderson Cancer Center | Phase 2 |
| Terminated | FNA Tumor Sampling for CD137 Modulation: A Pilot Study NCT01114256 | Stanford University | — |
| Completed | Temsirolimus (CCI-770, Torisel) Combined With Cetuximab in Cetuximab-Refractory Colorectal Cancer NCT00593060 | Jeffrey W. Clark, MD | Phase 1 |
| Completed | Expanded Cohort for Metastatic Colorectal Cancer (MCRC) Using Bevacizumab + Everolimus NCT00597506 | Herbert Hurwitz | Phase 2 |
| Completed | Trends and Outcomes in Laparoscopic Versus Open Surgery for Rectal Cancer NCT03683446 | Catherine H. Davis, MD | — |
| Completed | Safety and Efficacy of S-8184 in Second Line Treatment of Stage III or IV Colorectal Adenocarcinoma NCT00034190 | Achieve Life Sciences | Phase 2 |
| Completed | Study of 5-FU + Leucovorin + CPT-11 in Patients With Resectable Liver Metastases From Colorectal Adenocarcinom NCT00168155 | Alberta Health services | Phase 2 |
| Completed | Capecitabine and Thalidomide in Previously Treated Metastatic Colorectal Carcinoma NCT00165217 | Dana-Farber Cancer Institute | Phase 2 |