Trials / Completed
CompletedNCT03095781
Pembrolizumab and XL888 in Patients With Advanced Gastrointestinal Cancer
Phase Ib Trial of Pembrolizumab and XL888 in Patients With Advanced Gastrointestinal Malignancies
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 49 (actual)
- Sponsor
- Emory University · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This phase Ib trial studies the side effects and best dose of Hsp90 inhibitor XL888 when given together with pembrolizumab in treating patients with advanced gastrointestinal cancer that has spread to other places in the body. XL888 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as pembrolizumab, may block tumor growth in different ways by targeting certain cells. Giving XL888 with pembrolizumab may work better in treating patients with gastrointestinal cancer.
Detailed description
PRIMARY OBJECTIVE: I. Determine the recommended phase II dose for the combination of XL888 and pembrolizumab. SECONDARY OBJECTIVES: I. Define the toxicity profile of the combination of XL888 and pembrolizumab. II. Evaluate the activity of the combination of XL888 and pembrolizumab in previously treated patients with gastrointestinal tumors. TERTIARY OBJECTIVE: I. Evaluate the effect of the combination on the immune profile in the serum and in tumor biopsies. OUTLINE: This is a dose-escalation study of Hsp90 inhibitor XL888. Patients receive pembrolizumab intravenously (IV) over 30 minutes on day 1 and XL888 orally (PO) on day 1, 4, 8, 11, 15, and 18. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up at 30 days and periodically thereafter.
Conditions
- Colorectal Adenocarcinoma
- Metastatic Pancreatic Adenocarcinoma
- Recurrent Colorectal Carcinoma
- Recurrent Pancreatic Carcinoma
- Stage III Colorectal Cancer
- Stage III Pancreatic Cancer
- Stage IIIA Colorectal Cancer
- Stage IIIB Colorectal Cancer
- Stage IV Colorectal Cancer
- Stage IV Pancreatic Cancer
- Stage IVA Colorectal Cancer
- Stage IVA Pancreatic Cancer
- Stage IVB Colorectal Cancer
- Stage IVB Pancreatic Cancer
- Unresectable Pancreatic Carcinoma
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | XL888 | Given PO |
| BIOLOGICAL | Pembrolizumab | Given IV |
Timeline
- Start date
- 2017-07-07
- Primary completion
- 2021-06-10
- Completion
- 2021-06-10
- First posted
- 2017-03-30
- Last updated
- 2023-12-05
Locations
3 sites across 1 country: United States
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT03095781. Inclusion in this directory is not an endorsement.