| Not Yet Recruiting | Trial of Tirzepatide for the Treatment of Cannabis Use Disorder NCT07468552 | National Institute on Drug Abuse (NIDA) | Phase 2 |
| Not Yet Recruiting | Tirzepatide for the Treatment of Cannabis Use Disorder NCT07265752 | Brigham and Women's Hospital | Phase 2 |
| Not Yet Recruiting | Sex Differences in Neurobehavioral Response to THC NCT07225777 | Medical University of South Carolina | Phase 2 |
| Not Yet Recruiting | Effect of Semaglutide on Cannabis Use in Adults With Cannabis Use Disorder NCT07523633 | Anders Fink-Jensen, MD, DMSci | Phase 2 |
| Recruiting | Neuroimaging of Adolescent Cannabis Use Treatment NCT07340554 | Indiana University | N/A |
| Recruiting | Effects of Action-Based Cognitive Remediation on Substance Misuse in Early Phase Psychosis NCT07056894 | Nova Scotia Health Authority | N/A |
| Recruiting | Cannabis Reduction and Functional Outcomes NCT07218471 | Medical University of South Carolina | N/A |
| Not Yet Recruiting | Emotional Brain Training for Addiction Medicine Treatment - A Pilot Study NCT07001371 | Loma Linda University | N/A |
| Recruiting | Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use NCT06878859 | Massachusetts General Hospital | N/A |
| Not Yet Recruiting | Testing the Efficacy of the Cannabis Clinic for Patients With Psychosis (CCP) Intervention for Cannabis Use Re NCT07245212 | King's College London | N/A |
| Recruiting | RS-tDCS for Cannabis Use Disorder: The C.A.R.E.S. Initiative NCT07184983 | NYU Langone Health | N/A |
| Recruiting | Study of Oral Fluid Testing Approach NCT06891235 | Boston Children's Hospital | — |
| Recruiting | Exercise Intervention as Treatment for People Using Cannabis (ExIT-C) NCT07091292 | The University of Hong Kong | N/A |
| Recruiting | Cannabis-Tobacco Co-Use Treatment Study NCT06883162 | Medical University of South Carolina | Phase 3 |
| Recruiting | Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use NCT06920238 | Trustees of Dartmouth College | Phase 1 |
| Recruiting | Evaluation of Suvorexant for Reduction of Brain Reactivity in Patients With Cannabis Use Disorder (Pilot Study NCT06584942 | Massachusetts General Hospital | Phase 4 |
| Recruiting | Stress and Pain in People Living With HIV NCT06784908 | Yale University | N/A |
| Enrolling By Invitation | Developing a Telehealth + mHealth Cannabis Use Intervention for Young Adults NCT06661031 | Boston Children's Hospital | N/A |
| Recruiting | A Study of Cannabidiol in Young Adult Cannabis Users NCT06569394 | University of Colorado, Denver | Phase 2 |
| Recruiting | Cannabidiol and Cannabis Concentrate Users NCT06575751 | University of Colorado, Denver | Phase 2 |
| Recruiting | Integrated Treatment for Enhancing Growth in Recovery During Adolescence NCT06395467 | Massachusetts General Hospital | N/A |
| Recruiting | Psilocybin-assisted Treatment for Cannabis Use Disorder NCT06660381 | Johns Hopkins University | Phase 1 |
| Recruiting | A Brief Intervention for Cannabis Use NCT06395389 | Medical University of South Carolina | N/A |
| Recruiting | Cannabinoids and Biological Reactivity to Stress NCT06430580 | Florida State University | EARLY_Phase 1 |
| Recruiting | Genetics of Cannabis Use Disorder and Cannabinoid Response in Humans NCT06058702 | Yale University | Phase 1 |
| Recruiting | Role of Pavlovian Mechanisms for Control Over Substance Use NCT06701487 | Technische Universität Dresden | — |
| Recruiting | Effects of THC on Alcohol Consumption and Neural Correlates of Reward NCT06446479 | University of Colorado, Denver | Phase 2 |
| Recruiting | Evaluation of a Brief Computerized and Smart Phone-based Intervention for Stress in Regular Cannabis Users NCT06085222 | Florida State University | N/A |
| Recruiting | Longitudinal Outpatient Treatment for Cannabis Use Disorder NCT06107062 | University of Colorado, Boulder | Phase 2 |
| Recruiting | Determining the Effect of Six Weeks of Cannabis Abstinence on Fronto- Striatal fMRI Markers in Adolescents Wit NCT06124846 | University of Minnesota | N/A |
| Completed | Deep Repetitive Transcranial Magnetic Stimulation for Cannabis Use Disorder NCT06114212 | St. Joseph's Healthcare Hamilton | N/A |
| Recruiting | Mitigating PTSD-CUD After Sexual Assault NCT05989841 | University of Nevada, Las Vegas | Phase 1 / Phase 2 |
| Not Yet Recruiting | Impact of tDCS on Cannabis Craving in Schizophrenia NCT05784961 | Centre hospitalier de Ville-Evrard, France | N/A |
| Recruiting | Rewards for Cannabis Abstinence-study NCT05836207 | Parnassia Addiction Research Centre | N/A |
| Recruiting | SCORE Emerging Adult Cannabis Use & Stress NCT05885542 | Medical University of South Carolina | Phase 1 / Phase 2 |
| Recruiting | Guanfacine Extended-release for Adolescents With Cannabis Use NCT05957848 | Orygen | Phase 2 |
| Completed | Investigating Two rTMS Strategies to Treat Cannabis Use Disorder NCT05720312 | Stanford University | N/A |
| Recruiting | Repetitive Transcranial Magnetic Stimulation for Cannabis Use Disorder NCT05859347 | Centre for Addiction and Mental Health | N/A |
| Withdrawn | Varenicline for the Treatment of Cannabis and Tobacco Use Disorders in Veterans NCT05294263 | VA Office of Research and Development | Phase 2 |
| Terminated | Understanding Effects of Cannabis Use and Abstinence on Neural Glutamate Homeostasis NCT05664763 | Yale University | EARLY_Phase 1 |
| Unknown | Assessment of the Effectiveness of an Integrative Therapy for Cannabis Misuse in Adolescents NCT05765409 | Centre Hospitalier St Anne | N/A |
| Unknown | Resistance Exercise and Cannabis Use NCT03867786 | Penn State University | N/A |
| Recruiting | RCT Comparing Avatar Intervention to Supportive Intervention to Reduce Cannabis Use in Patients With Psychotic NCT05704582 | Ciusss de L'Est de l'Île de Montréal | N/A |
| Active Not Recruiting | Regulated Cannabis Access in Basel NCT05522205 | Health Department of the Canton of Basel-Stadt | N/A |
| Recruiting | Phenotyping Patients With Alcohol and Cannabis Use Disorders Using the Addictions Neuroclinical Assessment NCT05855668 | Centre for Addiction and Mental Health | N/A |
| Completed | A Teleheath tDCS Approach to Decrease Cannabis Use NCT05005013 | NYU Langone Health | Phase 2 |
| Completed | Repetitive Transcranial Magnetic Stimulation to People With Cannabis Use Disorder (SToP-C-rTMS x CUD) NCT05292547 | The University of Hong Kong | N/A |
| Completed | A Cannabis E-intervention for Young Cannabis Users With Early Psychosis (iCC) NCT05310981 | Centre hospitalier de l'Université de Montréal (CHUM) | N/A |
| Recruiting | Investigating the Neural Correlates of Cognitive Function in Psychosis Patients and Non-Psychiatric Controls W NCT05445180 | Douglas Mental Health University Institute | N/A |
| Recruiting | SV2A Density Cannabis Use Disorder NCT05472818 | Yale University | EARLY_Phase 1 |
| Recruiting | The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV NCT05453513 | University of Miami | N/A |
| Active Not Recruiting | Breathwork-assisted Treatment for Cannabis Use Disorder NCT05219825 | Elias Dakwar | N/A |
| Terminated | Vivitrol Treatment for Cannabis Use Disorder NCT04139668 | Centre for Addiction and Mental Health | Phase 2 |
| Completed | Investigating Stress-related Mechanisms in the Laboratory and Real World in Individuals With Cannabis Use Diso NCT04116619 | Yale University | — |
| Completed | Pilot Testing the Check Up NCT04624074 | University of Maryland, Baltimore | N/A |
| Unknown | Comparing the Spanish Version of CANreduce With or Without Psychological Support and Treatment as Usual, Reduc NCT04517474 | Parc de Salut Mar | N/A |
| Completed | Reducing Cannabis Overuse With Prazosin NCT04721353 | VA Puget Sound Health Care System | Phase 4 |
| Completed | UH3 Varenicline for Cannabis Use Disorder NCT03980561 | Medical University of South Carolina | Phase 2 |
| Unknown | Avatar Intervention for the Treatment of Cannabis Use Disorder in Patients With Severe Mental Health Disorders NCT05726617 | Ciusss de L'Est de l'Île de Montréal | N/A |
| Terminated | Lorcaserin for Cannabis Use Disorder NCT03637842 | New York State Psychiatric Institute | EARLY_Phase 1 |
| Withdrawn | Maternal Marijuana Use and Fetal and Infant Outcome NCT04266314 | Johns Hopkins University | — |
| Completed | Approach Bias Modification for the Treatment of Cannabis Use Disorder NCT03629990 | Medical University of South Carolina | N/A |
| Completed | Fatty Acid Amide Hydrolase (FAAH) Inhibitor Treatment of Cannabis Use Disorder (CUD) NCT03386487 | Yale University | Phase 2 |
| Completed | The Influence of in Utero Cannabis Exposure on Neonatal Brain Morphology and Structural Connectivity NCT03718520 | University of Colorado, Denver | — |
| Withdrawn | Effects of Cannabis Abstinence on Symptomology and Cognition in Bipolar Disorder NCT03629106 | Centre for Addiction and Mental Health | N/A |
| Completed | Substance Misuse To Psychiatric Disorders for Cannabis NCT03485274 | The University of Hong Kong | Phase 2 / Phase 3 |
| Completed | Affective Management Training for Cannabis Misuse NCT03432013 | University of California, Los Angeles | N/A |
| Completed | Evaluation of the Effects of Cannabidiol (CBD) Compared to Delta-9-Tetrahydrocannabinol (THC) and Alprazolam NCT03398083 | National Institute on Drug Abuse (NIDA) | Phase 1 |
| Recruiting | SV2 PET Imaging With [11C]APP311 NCT03995121 | Yale University | — |
| Completed | Effects of Cannabis Abstinence on Symptoms and Cognition in Depression NCT03624933 | Centre for Addiction and Mental Health | N/A |
| Completed | Progesterone for Cannabis Withdrawal NCT03430050 | Medical University of South Carolina | EARLY_Phase 1 |
| Completed | Gabapentin for Bipolar & Cannabis Use Disorders NCT03334721 | Medical University of South Carolina | Phase 2 |
| Completed | Brain Imaging of Cannabinoid Receptors NCT03204305 | Johns Hopkins University | EARLY_Phase 1 |
| Completed | N-Acetylcysteine for Youth Cannabis Use Disorder NCT03055377 | Medical University of South Carolina | Phase 2 / Phase 3 |
| Completed | A Preliminary Investigation of Pre-Frontal Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatme NCT03144232 | Stanford University | Phase 2 |
| Completed | Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Cannabis Use and Cognitive Outcomes in Schiz NCT03189810 | Centre for Addiction and Mental Health | N/A |
| Completed | Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC) NCT03056482 | Dr. Marco L.A. Sivilotti | Phase 4 |
| Completed | Effect of Clonazepam on Cannabis Withdrawal and Relapse in Treatment-seeking Patients NCT02913924 | New York State Psychiatric Institute | Phase 2 |
| Terminated | rTMS Treatment for Cannabis Use Disorders in Psychosis NCT03069612 | Centre for Addiction and Mental Health | N/A |
| Completed | Use of a Mobile Health Sensor in an Open Label Trial of Lorcaserin for the Treatment of Cannabis Use Disorder NCT02932215 | New York State Psychiatric Institute | Phase 1 |
| Completed | Treatment of Cannabis Use Disorder Among Adults With Comorbid Attention-Deficit/Hyperactivity Disorder NCT02803229 | New York State Psychiatric Institute | Phase 2 / Phase 3 |
| Completed | Computerized Intervention for Distress Intolerance NCT04173078 | Auburn University | N/A |
| Unknown | N-acetylcysteine for the Treatment of Cannabis Dependence: Working Mechanisms NCT03221231 | Universitair Ziekenhuis Brussel | Phase 4 |
| Completed | Cannabidiol Pharmacotherapy for Adults With Cannabis Use Disorder NCT03102918 | Mclean Hospital | Phase 1 |
| Completed | Clinical Trial Tobacco Marijuana NCT02277665 | Dartmouth-Hitchcock Medical Center | N/A |
| Completed | Pharmacological Treatment of Comorbid Alcohol and Marijuana Withdrawal and Dependence NCT02210195 | The Scripps Research Institute | Phase 2 |
| Completed | Cannabis, Schizophrenia and Reward: Self-Medication and Agonist Treatment? NCT01964404 | Dartmouth-Hitchcock Medical Center | Phase 1 |
| Completed | Cannabidiol: a Novel Intervention for Cannabis Use Problems? NCT02044809 | University College, London | Phase 2 |
| Unknown | Cannabidiol (CBD) for the Management of Cannabis Withdrawal: A Phase II Proof of Concept Study NCT02083874 | The University of New South Wales | Phase 2 |
| Completed | Integrated CBT for Cannabis Dependence With Co-occurring Anxiety Disorders NCT01875796 | Louisiana State University and A&M College | Phase 1 |
| Completed | Buspirone, Stress, and Attentional Bias to Marijuana Cues NCT02132832 | The University of Texas Health Science Center, Houston | Phase 2 |
| Completed | Adaptive Treatment for Adolescent Cannabis Use Disorders NCT01656707 | UConn Health | N/A |
| Completed | Teen Marijuana Check-Up NCT01109563 | Denise Walker | Phase 3 |
| Completed | Cannabis and Schizophrenia: Self-Medication and Agonist Treatment NCT00946348 | Dartmouth-Hitchcock Medical Center | Phase 1 |
| Completed | Bupropion for ADHD in Adolescents With Substance Use Disorder NCT00936299 | University of Colorado, Denver | Phase 4 |
| Unknown | CANDIS - Targeted Treatment for Cannabis Disorders NCT00252980 | Technische Universität Dresden | Phase 2 |