NCT06891235

Study of Oral Fluid Testing Approach

Oral Fluid Testing to Assess Cannabis Non-Use in Remote Clinical Trials

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Boston Children's Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to identify and evaluate oral fluid testing as a biologic measure of cannabis use days that can be assessed remotely. The researchers will conduct this fully virtual study among a community sample of 200 individuals aged 18-30 years who have used cannabis at least 1 time per week on average in the past 30 days. Participants will complete oral fluid (saliva) tests, urine tests, and Timeline Follow-back interviews (self-report) that indicate their recent cannabis use (delta-9-THC). Participants will present for 3 virtual study visits across \~3-4 weeks and be asked to complete activities in between: Study Visit 1 (Day 0; informed consent, baseline survey, TLFB interview), Study Visit 2 (\~Day 7; TLFB interview, urine testing), 6 days of at-home videorecorded oral fluid testing, Study Visit 3 (\~Day 21; TLFB interview, urine test, oral fluid test, survey, interview).

Conditions

• Cannabis Use
• Cannabis Intoxication
• Cannabis Use Disorder

Interventions

Type	Name	Description
OTHER	Biologic testing for THC	Participants will be asked to complete at-home urine test(s) and a series of oral fluid tests.

Timeline

• Start date: 2025-10-27
• Primary completion: 2027-02-01
• Completion: 2027-05-01
• First posted: 2025-03-24
• Last updated: 2026-03-11

Locations

1 site across 1 country: United States