NCT05453513

The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 280 (estimated)
• Sponsor: University of Miami · Academic / Other
• Sex: All
• Age: 18 Years – 59 Years
• Healthy volunteers: Not accepted

Summary

To elucidate mechanisms of substance use disorders (SUD) and comorbid mental illnesses in people living with HIV (PLWH), the study team seeks to investigate reward and pain circuitry in cannabis use and depression comorbidity, two highly prevalent conditions in PLWH. The study team proposes a tightly integrative study to test the overall hypothesis that cannabis use and depression in young PLWH have an additive effect, inducing both reward deficits and pain hypersensitivity, and that this pattern will predict worse outcomes at 1 year follow-up.

Conditions

• Depression
• Cannabis Use Disorder
• HIV

Interventions

Type	Name	Description
BEHAVIORAL	MRI Study	fMRI Tasks

Timeline

• Start date: 2022-04-01
• Primary completion: 2027-07-30
• Completion: 2027-07-30
• First posted: 2022-07-12
• Last updated: 2025-07-28

Locations

1 site across 1 country: United States