Trials / Not Yet Recruiting
Not Yet RecruitingNCT07225777
Sex Differences in Neurobehavioral Response to THC
Sex Differences in Neurobehavioral Response to Acute THC in Adults With Cannabis Use Disorder
- Status
- Not Yet Recruiting
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- Sponsor
- Medical University of South Carolina · Academic / Other
- Sex
- All
- Age
- 21 Years – 45 Years
- Healthy volunteers
- Not accepted
Summary
This study investigates sex differences in reward processing following acute THC administration in adults with cannabis use disorder (CUD). Using multimodal neuroimaging (MRS and fMRI), the study will assess glutamate levels in the nucleus accumbens and striatal BOLD response to monetary reward anticipation. Participants will complete two counterbalanced dosing sessions (oral THC 40 mg vs. placebo).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Dronabinol | Oral dronabinol capsules (40 mg) |
| DRUG | Placebo | Matched placebo capsules |
Timeline
- Start date
- 2026-05-01
- Primary completion
- 2027-12-31
- Completion
- 2027-12-31
- First posted
- 2025-11-10
- Last updated
- 2026-04-08
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT07225777. Inclusion in this directory is not an endorsement.