Trials / Recruiting
RecruitingNCT05957848
Guanfacine Extended-release for Adolescents With Cannabis Use
Guanfacine Extended-release Randomised Controlled Trial for Adolescents With Cannabis usE (GRACE)
- Status
- Recruiting
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- Sponsor
- Orygen · Academic / Other
- Sex
- All
- Age
- 12 Years – 25 Years
- Healthy volunteers
- Not accepted
Summary
A randomized controlled trial to assess the efficacy of extended-release guanfacine to reduce cannabis use frequency in young people with cannabis use disorder following a period of monitored abstinence.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Guanfacine Extended Release Oral Tablet | Target dose 4 mg daily |
| BEHAVIORAL | Residential withdrawal | 4-14 days in residential withdrawal treatment |
| BEHAVIORAL | Engagement with alcohol and other drug services | Ongoing engagement with a youth drug and alcohol service for counselling or other support for the duration of the study |
| DRUG | Placebo | Placebo capsule taken daily |
Timeline
- Start date
- 2023-07-27
- Primary completion
- 2025-12-31
- Completion
- 2026-06-30
- First posted
- 2023-07-24
- Last updated
- 2025-07-31
Locations
1 site across 1 country: Australia
Source: ClinicalTrials.gov record NCT05957848. Inclusion in this directory is not an endorsement.