NCT07218471

Cannabis Reduction and Functional Outcomes

Prospective Changes in Patient-reported and Objective Functioning Following Reduction of Cannabis Use

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 176 (estimated)
• Sponsor: Medical University of South Carolina · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates the effects of cannabis use reduction among adults diagnosed with cannabis use disorder (CUD). Participants will undergo an 8-week intervention combining motivational interviewing, computerized cognitive behavioral therapy (CBT4CBT), and financial incentives for reduction in urinary cannabinoids. The study aims to assess improvements in cannabis-related problems, sleep, cognitive performance, CUD severity, and quality of life.

Conditions

• Cannabis Use Disorder

Interventions

Type	Name	Description
BEHAVIORAL	CBT4CBT (Computerized Cognitive Behavioral Therapy)	Participants will receive one therapist-led motivational interviewing/goal setting session followed by 7 sessions of computerized CBT4CBT.
BEHAVIORAL	Motivational Interviewing	Participants will receive one therapist-led motivational interviewing/goal setting session followed by 7 sessions of computerized CBT4CBT.
BEHAVIORAL	Contingency Management	Patients will receive contingent reinforcers (financial incentives for reduction in urinary cannabinoids).

Timeline

• Start date: 2026-03-13
• Primary completion: 2029-09-15
• Completion: 2030-01-30
• First posted: 2025-10-20
• Last updated: 2026-03-19

Locations

1 site across 1 country: United States