| Recruiting | Detection of Brain Metastases Using a Novel Gadolinium-Weighted MRI Sequence: A Prospective Comparison NCT07272616 | Region Stockholm | — |
| Recruiting | OT SMILE: Occupational Therapy Group Intervention for Primary Brain Tumour Patients NCT07426848 | Royal College of Surgeons, Ireland | N/A |
| Recruiting | DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 NCT05770544 | Cancer Research UK | Phase 2 / Phase 3 |
| Recruiting | HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer) NCT06930846 | Dartmouth-Hitchcock Medical Center | N/A |
| Recruiting | Intraoperative Fluorescence-Guided Aspirate Tissue Monitoring of 5-ALA During Brain Tumor Surgery NCT07111182 | University of Illinois at Chicago | N/A |
| Active Not Recruiting | [18F]FET PET for Characterization of Progressive or Recurrent Glioma From Treatment Related Changes NCT07238322 | Telix Pharmaceuticals (Innovations) Pty Limited | — |
| Completed | Use of Fluorescence in Gliomas NCT07499141 | Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria | — |
| Not Yet Recruiting | Clinical Trial for the Validation of AR Based Neuronavigation System NCT05776706 | Seoul National University Hospital | N/A |
| Withdrawn | Physical Activity and Quality of Life in Childhood Cancersurvivors- a Long-term Follow-up NCT07046481 | Region Skane | N/A |
| Completed | Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent NCT06322342 | Reveal Pharmaceuticals Inc. | Phase 2 |
| Recruiting | Guided Meditation During Radiation Therapy for Brain Tumors NCT06165653 | University of Utah | N/A |
| Recruiting | Ommaya Reservoir Placement at the Time of Biopsy for Longitudinal Biomarker Collection in Patients With Brain NCT06322602 | Mayo Clinic | N/A |
| Recruiting | SGM-101 in Colorectal Brain Metastases. NCT04755920 | Leiden University Medical Center | Phase 2 |
| Unknown | Fast Brain MRI in Children With Suspected Brain Tumor NCT05776602 | Karolinska University Hospital | — |
| Recruiting | The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma NCT06273176 | Erasmus Medical Center | — |
| Recruiting | Prognosis Prediction System of Patients With Cardiovascular and Cerebrovascular Diseases Based on Multi-omics NCT06001073 | First Affiliated Hospital Xi'an Jiaotong University | — |
| Recruiting | A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With A NCT05538130 | Pfizer | Phase 1 |
| Recruiting | Platelets Activation in Brain Neoplasms NCT05049148 | Fondation Ophtalmologique Adolphe de Rothschild | N/A |
| Recruiting | Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer NCT05386108 | Stemline Therapeutics, Inc. | Phase 1 / Phase 2 |
| Completed | Brain Tumor Intraoperative Ultrasound Database NCT05062772 | Hospital del Rio Hortega | — |
| Recruiting | Phase I Study of JYP0322 in ROS1 Fusion-Positive Solid Tumors NCT06128148 | Guangzhou JOYO Pharma Co., Ltd | Phase 1 |
| Completed | Clinical Application of the Prototype J-PET Device NCT06211803 | Jagiellonian University | — |
| Completed | EMERGENCE AGITATION After Premedication IN PAEDIATRIC MAGNETIC RESONANCE IMAGING: A RETROSPECTIVE COHORT STUDY NCT05946928 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Recruiting | The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 220 NCT06118723 | Jasper Gerritsen | — |
| Terminated | Study of [68Ga]-FF58 in Patients With Selected Solid Tumors Expected to Overexpress αvβ3 and αvβ5 Integrins. NCT04712721 | Novartis Pharmaceuticals | EARLY_Phase 1 |
| Active Not Recruiting | BRAINFUL (BRAIN Tumor Focused Ultrasound-enabled Liquid Biopsy) Trial NCT04940507 | University Health Network, Toronto | N/A |
| Terminated | A Home-Based Approach Study to Evaluate the Efficacy and Safety of Alectinib in Locally-Advanced or Metastatic NCT04644315 | Hoffmann-La Roche | Phase 2 |
| Terminated | A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involveme NCT04543188 | Pfizer | Phase 1 |
| Unknown | IORT After Surgical Resection of Brain Metastases NCT05084092 | Institut Català d'Oncologia | Phase 2 |
| Recruiting | Diagnostic Assessment of Amino Acid PET/MRI in the Evaluation of Glioma and Brain Metastases NCT04111588 | Norwegian University of Science and Technology | — |
| Recruiting | The SAFE-Trial: Awake Craniotomy Versus Surgery Under General Anesthesia for Glioblastoma Patients. NCT03861299 | Jasper Gerritsen | N/A |
| Completed | Comparison of 6-fluoro-[18F]-L-dihydroxyphenylalanine (18F-DOPA) Positron Emission Tomography (PET) and Multip NCT03525080 | Center Eugene Marquis | N/A |
| Unknown | Comparative Study Between Different Approaches to CPA-petroclival Meningiomas NCT03462914 | Assiut University | — |
| Withdrawn | Multi-modality Localization of Eloquent Brain Function NCT02795338 | University of Nebraska | — |
| Completed | Functional Outcomes of The Bobath Approach on Patients With Brain Tumors: Comparison With Stroke Patients NCT03574467 | Hacettepe University | — |
| Terminated | CureOne Registry: Advanced Malignancy or Myelodysplasia, Tested by Standard Sequencing and Treated by Physicia NCT02900248 | CureOne | — |
| Unknown | Role of MR Spectroscopy in Brain Tumors NCT03619694 | Assiut University | — |
| Unknown | Bevacizumab and Erlotinib in Lung Cancer With Brain Metastases, a Phase II Trial NCT02655536 | National Taiwan University Hospital | Phase 2 |
| Completed | The Effect of Vitamin D3 on Postoperative Pain in Patients Undergoing Craniotomy NCT03614403 | Shahid Beheshti University | N/A |
| Completed | Therapeutic Benefit of Preoperative Supplemental Vitamin D in Patients Undergoing Brain Tumor Surgery NCT03248544 | Shahid Beheshti University | N/A |
| Active Not Recruiting | MR Elastography in Intracranial Lesions: Feasibility & Accuracy NCT06916715 | Shengjing Hospital | — |
| Terminated | Improving Ultrasound Images in Brain Tumour Surgery With the Use of an Acoustic Coupling Fluid Mimicking Brain NCT03181581 | St. Olavs Hospital | Phase 2 |
| Completed | Effectiveness of Musical Training in Hong Kong Chinese Childhood Brain Tumor Survivors NCT03399864 | The University of Hong Kong | N/A |
| Completed | Re-craniotomy and Complications After Elective Neurosurgery NCT03910556 | Chiang Mai University | — |
| Completed | Hypovitaminosis D in Neurocritical Patients NCT02881957 | University of Utah | Phase 2 / Phase 3 |
| Terminated | Study of Genistein in Pediatric Oncology Patients (UVA-Gen001) NCT02624388 | University of Virginia | Phase 2 |
| Completed | An Investigational Immuno-therapy Study of Temozolomide Plus Radiation Therapy With Nivolumab or Placebo, for NCT02667587 | Bristol-Myers Squibb | Phase 3 |
| Withdrawn | SPECTAbrain: Screening Patients With Brain Tumors for Efficient Clinical Trial Access NCT02307604 | European Organisation for Research and Treatment of Cancer - EORTC | — |
| Completed | Evaluation of Anatomy, Clinical and Neuropsychological Long-term Sequelae of Patients Treated With Radiation T NCT02791360 | Centre Francois Baclesse | N/A |
| Completed | Effectiveness of Musical Training in Children Surviving Brain Tumours NCT02754908 | The University of Hong Kong | N/A |
| Completed | Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) NCT01931098 | National Cancer Institute (NCI) | Phase 2 |
| Suspended | An Evaluation of Non-Invasive ICP Monitoring in Patients Undergoing Invasive ICP Monitoring Via an Intraparenc NCT02773888 | HeadSense Medical | N/A |
| Completed | Dexmedetomidine and Intelligence Development in Pediatric Patients Undergoing Craniotomy NCT02810899 | Peking University First Hospital | Phase 4 |
| Completed | 1 Week Versus 6 Weeks of Levetiracetam in Surgical Brain Tumor Patients NCT02334722 | University of Florida | Phase 4 |
| Completed | Fluid Therapy During Brain Tumor Resection in Children NCT02707549 | Federal University of São Paulo | Phase 2 |
| Completed | Use of Fluorescein Dye for the Removal of Brain Tumors NCT02389530 | University of Pittsburgh | — |
| Terminated | Local Radiotherapy Following Complete Resection of a Brain Metastasis NCT02729558 | Amsterdam UMC, location VUmc | N/A |
| Completed | Health Related Quality of Life in Pediatric Central Nervous System (CNS) Tumors: A Feasibility Study Utilizing NCT02603692 | Children's Hospital Medical Center, Cincinnati | — |
| Unknown | An Evaluation of a Non-invasive Brain Monitor NCT02775136 | HeadSense Medical | N/A |
| Unknown | Treatment of Recurrent Brain Tumors: Metabolic Manipulation Combined With Radiotherapy NCT02149459 | Sheba Medical Center | Phase 1 |
| Completed | Improving Ultrasound Images in Brain Tumor Surgery With the Use of Brain Mimicking Fluid NCT02105233 | St. Olavs Hospital | Phase 1 |
| Completed | Presurgical Language Mapping With fMRI: Comparison of BOLD and fASL Techniques NCT01793714 | Rennes University Hospital | — |
| Unknown | Small-dose Dexmedetomidine Effects on Recovery Profiles of Supratentorial Tumors Patients From General Anesthe NCT02007798 | China Medical University, China | N/A |
| Terminated | NovoTTF Therapy in Treating Patients With Recurrent Glioblastoma Multiforme NCT01954576 | University of Florida | N/A |
| Completed | Improving Surgical Outcomes in Patients With Low Grade Gliomas Using Advanced Pre- and Intra-operative MRI NCT02884947 | University College, London | — |
| Completed | Cerebral Blood Perfusion Changes After General Anesthesia for Craniotomy NCT01642147 | Huashan Hospital | N/A |
| Terminated | Phase I/II Bevacizumab Versus Bevacizumab Plus TPI 287 for Recurrent Glioblastoma NCT01582152 | M.D. Anderson Cancer Center | Phase 1 / Phase 2 |
| Completed | MRI for the Early Evaluation of Acute Intracerebral Hemorrhage NCT01689402 | Bispebjerg Hospital | — |
| Terminated | Pilot Study of Vardenafil and Carboplatin in Patients With Gliomas and Brain Metastases NCT02279992 | Cedars-Sinai Medical Center | EARLY_Phase 1 |
| Completed | A Study of the Specificity and Sensitivity of 5- Aminolevulinic Acid (ALA) Fluorescence in Malignant Brain Tum NCT01128218 | Southern Illinois University | Phase 1 / Phase 2 |
| Completed | Social Cognition in Children Treated for a Brain Tumour NCT01599052 | University Medical Center Groningen | — |
| Withdrawn | RO4929097 in Children With Relapsed/Refractory Solid or CNS Tumors, Lymphoma, or T-Cell Leukemia NCT01236586 | National Cancer Institute (NCI) | Phase 1 |
| Completed | FLT-PET Imaging of Brain Tumors in Children NCT01244737 | Frederick Daniel Grant | Phase 2 |
| Completed | Optimal Planning Target Volume With Stereotactic Radiosurgery NCT01017497 | Duke University | N/A |
| Unknown | In Vivo Confocal Microscopy Tumor Atlas Study NCT01012154 | Carl Zeiss Surgical GmbH | Phase 1 |
| Completed | Efficiency of Two Glucose Sampling Protocols for Maintenance of Euglycemia NCT00993057 | Northwestern University | EARLY_Phase 1 |
| Withdrawn | A Study of the Specificity and Sensitivity of 5-ALA Fluorescence in Malignant Brain Tumors NCT00977795 | Endeavor Health | Phase 1 / Phase 2 |
| Withdrawn | Assessment of Systemically Administered Torisel Delivery to Brain Tumors by Intratumoral Microdialysis NCT00949026 | Emory University | Phase 1 |
| Terminated | Assessing Dynamic Magnetic Resonance (MR) Imaging in Patients With Recurrent High Grade Glioma Receiving Chemo NCT00769093 | OHSU Knight Cancer Institute | Phase 1 |
| Unknown | Magnetic Resonance Imaging-Guided Laser Induced Thermal Therapy for Treatment of Metastatic Brain Tumors NCT00787982 | Visualase, Inc. | Phase 1 / Phase 2 |
| Completed | In Vivo Confocal Endomicroscopy of the Brain NCT00949793 | Carl Zeiss Surgical GmbH | Phase 1 |
| Completed | A Phase I Study of ABT-888 in Combination With Conventional Whole Brain Radiation Therapy (WBRT) in Cancer Pat NCT00649207 | AbbVie (prior sponsor, Abbott) | Phase 1 |
| Withdrawn | Intravenous Anesthesia Versus Anesthesia With Volatile Agents in Elective Craniotomy for Tumors NCT00555984 | The Cleveland Clinic | N/A |
| Unknown | The Influence of Radiotherapy on Cognitive Function NCT00457210 | Tel-Aviv Sourasky Medical Center | — |
| Completed | Bevacizumab and Irinotecan for Patients With Primary Brain Tumors and Progression After Standard Therapy NCT00463203 | Rigshospitalet, Denmark | Phase 2 |
| Terminated | A Phase 1 / 2 Dose Escalation Study of Locally-Administered OncoGel™ in Subjects With Recurrent Glioma NCT00479765 | Boston Scientific Corporation | Phase 1 / Phase 2 |
| Unknown | Stereotactic Radiosurgery to the Resection Cavity Following Surgical Removal of Brain Metastasis NCT00484978 | Tel-Aviv Sourasky Medical Center | Phase 2 |
| Completed | Clinical Evaluation of Navigated 3D Ultrasound Multicentre Study NCT00233350 | Norwegian University of Science and Technology | — |
| Completed | MR Guided Laser Interstitial Thermal Therapy for the "Minimal Invasive" Treatment of Brain Metastasis and Prim NCT00392119 | BioTex, Inc. | Phase 1 |
| Completed | A Pilot Study of Dronabinol for Adult Patients With Primary Gliomas NCT00314808 | Duke University | Phase 1 |
| Completed | A Study of Bevacizumab in Combination With First- or Second-Line Therapy in Subjects With Treated Brain Metast NCT00312728 | Genentech, Inc. | Phase 2 |
| Completed | Temozolomide, Thalidomide, and Lomustine (TTL) in Melanoma Patients NCT00527657 | M.D. Anderson Cancer Center | Phase 1 |
| Completed | A Trial of Postoperative Whole Brain Radiation Therapy vs. Salvage Stereotactic Radiosurgery Therapy for Metas NCT00280475 | Haruhiko Fukuda | Phase 3 |
| Completed | Whole Brain Radiotherapy With or Without Temozolomide at Daily Fixed-dose for Brain Metastases Treatment NCT01015534 | Instituto Nacional de Cancerologia de Mexico | Phase 2 |
| Completed | Multiple Dose Study of MPC-6827 in Subjects With Refractory Brain Metastases NCT00393965 | Myrexis Inc. | Phase 1 |
| Completed | 18F-fluorodeoxyglucose (18F-FDG) Positron Emission Tomography in Oncology NCT00207298 | British Columbia Cancer Agency | — |
| Completed | Study of Tomotherapy in Patients With Benign Brain Tumour NCT00128986 | AHS Cancer Control Alberta | Phase 1 |
| Completed | Radiotherapy - Cerebrovascular Reactivity (RT-CVR Study) NCT00297024 | University Health Network, Toronto | Phase 2 |
| Completed | MRI Study of Radiation-Induced Damage to White Matter and Blood-Brain-Barrier NCT01988675 | University of Michigan Rogel Cancer Center | — |
| Terminated | Iressa in the Treatment of Brain Metastases From Non Small Cell Lung Cancer NCT00234442 | AstraZeneca | Phase 2 |
| Completed | Determination of Fraction Size Equivalent Dose (FED) Levels for Intracranial Conformal Avoidance Radiotherapy NCT00214175 | University of Wisconsin, Madison | — |
| Completed | Temozolomide for Treatment of Brain Metastases From Non-Small Cell Lung Cancer (Study P03247) NCT00076856 | Merck Sharp & Dohme LLC | Phase 2 |
| Completed | Study of 18F-Fluorodeoxyglucose (FluGlucoScan) in Patients With Cancer or Suspected Cancer NCT00123760 | AHS Cancer Control Alberta | Phase 2 / Phase 3 |
| Unknown | Study on Amino Acid Uptake in Brain Tumors NCT00204295 | University Hospital Muenster | Phase 2 |
| Completed | Surgery Versus Radiosurgery to Treat Metastatic Brain Tumors NCT00075166 | National Institute of Neurological Disorders and Stroke (NINDS) | Phase 4 |
| Completed | Magnevist (SH L 451A) Intra-individual Dose Comparison Study in Patients With Brain Metastasis NCT00681551 | Bayer | Phase 3 |
| Terminated | Study of Vioxx and Radiation Therapy for Brainstem Glioma NCT00038389 | M.D. Anderson Cancer Center | Phase 1 |
| Completed | Study of Karenitecin (BNP1350) in Patients With Brain Tumors NCT00062478 | BioNumerik Pharmaceuticals, Inc. | Phase 2 |
| Terminated | Study of Temozolomide in the Treatment of Brain Metastasis From Non-small-cell Lung Cancer (Study P02143) NCT00034697 | Merck Sharp & Dohme LLC | Phase 2 |
| Terminated | Imaging of Intravenous (IV) Combidex to Brain, Intra-cerebral Tumors and in Central Nervous System (CNS) Infla NCT00659334 | OHSU Knight Cancer Institute | Phase 2 |
| Completed | (1)H-Nuclear Magnetic Resonance Spectroscopic Imaging of the Brain in Patients Who Receive Neurotoxic Therapy NCT00001807 | National Cancer Institute (NCI) | — |
| Completed | Phase I and Pharmacokinetic Trial of Phenylbutyrate Given as a Continuous Infusion in Pediatric Patients With NCT00001565 | National Cancer Institute (NCI) | Phase 1 |
| Completed | A Pediatric Phase I Trial of RMP-7 and Carboplatin in Brain Tumors NCT00001502 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Brain Metastases Study: Radiotherapy Fractionation Schemes in the Treatment of Brain Metastases NCT00138788 | St George Hospital, Australia | Phase 3 |
| Completed | Phase I Trial of Intramural Injection of DTI-015 for Recurrent Malignant Gliomas NCT00038441 | M.D. Anderson Cancer Center | Phase 1 / Phase 2 |
| Unknown | Phase II Randomized Study of Stereotactic Radiosurgery Plus Fractionated Whole-Brain Radiotherapy Vs Fractiona NCT00004659 | National Institute of Neurological Disorders and Stroke (NINDS) | Phase 2 |
| Terminated | Study of Motexafin Gadolinium With Whole Brain Radiation Therapy Followed by Stereotactic Radiosurgery Boost i NCT00121420 | Pharmacyclics LLC. | Phase 2 |
| Completed | Study of Neurologic Progression With Motexafin Gadolinium and Radiation Therapy (SMART) NCT00054795 | Pharmacyclics LLC. | Phase 3 |
| Unknown | Study of 111In-DAC as an Medical Imaging Agent for Lung Cancer and Brain Cancer Consistent With Metastatic Lun NCT00040560 | Copharos | Phase 1 |