NCT01988675

MRI Study of Radiation-Induced Damage to White Matter and Blood-Brain-Barrier

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 91 (actual)
• Sponsor: University of Michigan Rogel Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a study to determine if Magnetic Resonance Imaging (MRI) techniques can detect early changes in white matter (in the brain) and the blood-brain barrier resulting from radiation therapy.

Detailed description

Patients will be assigned to one of two groups based on the type of radiation they will be receiving: whole brain irradiation or partial brain irradiation. Patients will undergo Magnetic Resonance Imaging (MRI) assessments, neurocognitive testing (Quality of Life and Neuropsychological assessments), and clinical evaluation.

Conditions

• Brain Neoplasms

Interventions

Type	Name	Description
RADIATION	Whole Brain Irradiation
RADIATION	Partial Brain Irradiation
BEHAVIORAL	Neuropsychological Testing
BEHAVIORAL	Quality of Life Questionnaire
DEVICE	Magnetic Resonance Imaging (MRI) Assessments	MRI Assessments include Diffusion Tensor Imaging (DTI)and Gd-DTPA (Diethylenetriamine Pentaacetic Acid - a radioactive tracer injected into the patient and viewed on images).

Timeline

• Start date: 2004-08-26
• Primary completion: 2014-06-03
• Completion: 2014-06-03
• First posted: 2013-11-20
• Last updated: 2018-06-06

Locations

1 site across 1 country: United States