NCT05084092

IORT After Surgical Resection of Brain Metastases

IORT After Surgical Resection of Brain Metastases: Feasibility and Efficacy Phase II Trial

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Institut Català d'Oncologia · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

To evaluate the feasibility and efficacy of the Intraoperative Radiation Therapy (IORT) after the resection of a brain metastases to reduce the incidence of local relapse

Conditions

• Brain Neoplasms

Interventions

Type	Name	Description
RADIATION	Intraoperative Radiotherapy (IORT)	If biopsy is positive, local treatment with IORT will be performed. After IORT (15,40 Gray at 2 mm dept), the applicator will be removed and surgery will be continued in a standard fashion.
PROCEDURE	Brain surgery	Surgery should be performed according to the local standard of care, preferentially as image-(neuronavigation) guided surgery. To establish the diagnosis of a metastasis and to exclude primary CNS tumors, lymphomas, SCLCs or germinomas it will be performed a peroperative biopsy

Timeline

• Start date: 2020-06-17
• Primary completion: 2023-12-01
• Completion: 2024-12-01
• First posted: 2021-10-19
• Last updated: 2022-08-04

Locations

1 site across 1 country: Spain