| Not Yet Recruiting | DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Y Haematological Malignancy, Malignant Neoplasm, Lymphoproliferative Disorders | Phase 2 / Phase 3 | 2026-02-01 |
| Recruiting | DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Haematological Malignancy, Malignancy, Malignant Neoplasm | Phase 2 / Phase 3 | 2025-11-30 |
| Recruiting | DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations Solid Tumour, Haematological Malignancy, Malignant Neoplasm | Phase 2 / Phase 3 | 2024-11-19 |
| Recruiting | A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer Advanced Solid Tumours, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung | Phase 1 / Phase 2 | 2024-07-09 |
| Recruiting | A Phase I/II Trial of ALETA-001 for the Treatment of Participants With B-cell Malignancies Lymphoma, Non-Hodgkin, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell | Phase 1 / Phase 2 | 2024-02-07 |
| Recruiting | DETERMINE Trial Treatment Arm 01: Alectinib in Adult, Paediatric and Teenage/Young Adult Patients With ALK Pos Haematological Malignancy, Malignant Neoplasm, Lymphoproliferative Disorders | Phase 2 / Phase 3 | 2023-12-18 |
| Recruiting | DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Canc Malignancy, Malignant Neoplasm, Lymphoproliferative Disorders | Phase 2 / Phase 3 | 2023-10-25 |
| Recruiting | HTL0039732 in Participants With Advanced Solid Tumours Neoplasms, Prostatic Neoplasms, Castration-Resistant, Stomach Neoplasms | Phase 1 / Phase 2 | 2023-07-13 |
| Recruiting | DETERMINE Trial Treatment Arm 04: Trastuzumab in Combination With Pertuzumab in Adult, Paediatric and Teenage/ Haematological Malignancy, Colorectal Neoplasms, Urinary Bladder Neoplasm | Phase 2 / Phase 3 | 2023-03-07 |
| Recruiting | DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Posi Haematological Malignancy, Melanoma, Thyroid Cancer, Papillary | Phase 2 / Phase 3 | 2023-03-01 |
| Recruiting | DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indicat Haematological Malignancy, Solid Tumour | Phase 2 / Phase 3 | 2023-03-01 |
| Recruiting | TT-702 in Patients With Advanced Solid Tumours. Advanced Solid Tumors | Phase 1 / Phase 2 | 2022-01-19 |
| Active Not Recruiting | A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours Bladder Cancer, Triple Negative Breast Cancer, Castration-resistant Prostate Cancer | Phase 1 / Phase 2 | 2021-11-10 |
| Suspended | A Trial of ChAdOx1 and MVA Vaccines Against MAGE-A3 and NY-ESO-1 Non-small Cell Lung Cancer (NSCLC), Squamous Oesophageal Cancer | Phase 1 / Phase 2 | 2021-10-15 |
| Terminated | A Trial Looking at the Use of Camostat in People Who Have Tested Positive for Coronavirus (COVID-19) (SPIKE-1) COVID-19 Infection | Phase 2 | 2020-09-23 |
| Completed | AST-VAC2 Vaccine in Patients With Non-small Cell Lung Cancer Advanced Non-small Cell Lung Cancer | Phase 1 | 2018-05-29 |
| Completed | BT1718 in Patients with Advanced Solid Tumours. Advanced Solid Tumours, Non-Small Cell Lung Cancer, Non-Small Cell Lung Sarcoma | Phase 1 / Phase 2 | 2018-01-24 |
| Active Not Recruiting | A CR-UK Phase I Trial of LY3143921 A. Colorectal Cancer, B. High Grade Serous Ovarian Cancer, C. Non Small-cell Lung Cancer (squamous Cell Variant) | Phase 1 | 2017-06-21 |
| Completed | BI-1206 and an Anti-CD20 Antibody in Patients With CD32b Positive B-cell Lymphoma or Leukaemia B-cell Lymphoma, Chronic Lymphocytic Leukaemia, Waldenström Macroglobulinemia | Phase 1 / Phase 2 | 2016-10-27 |
| Completed | A Phase I Trial of Anti-GD2 T-cells (1RG-CART) Relapsed or Refractory Neuroblastoma | Phase 1 | 2016-02-29 |
| Completed | Phase I Study of MOv18 IgE Human Cancers | Phase 1 | 2016-02-16 |
| Terminated | AMG 319 in HPV Positive and Negative HNSCC Human Papillomavirus (HPV), Positive or Negative Head and Neck Squamous Cell Carcinoma (HNSCC) of the Hypopharynx, Oropharynx, Oral Cavity, Supraglottis or Larynx | Phase 2 | 2015-10-01 |
| Completed | A Phase I/II Study of [124I]mIBG PET/CT in Neuroblastoma Metastatic Neuroblastoma | Phase 1 / Phase 2 | 2014-02-01 |
| Completed | A Phase I Trial of AZD3965 in Patients With Advanced Cancer Adult Solid Tumor, Diffuse Large B Cell Lymphoma, Burkitt Lymphoma | Phase 1 | 2013-04-23 |
| Completed | A Phase I Trial of DI-B4 in Patients With Advanced CD19 Positive Indolent B-cell Malignancies Indolent B-cell Lymphoma, Chronic Lymphocytic Leukaemia, Waldenström Macroglobulinaemia | Phase 1 | 2013-04-01 |
| Completed | A Phase Ib Trial of MVA-EBNA1/LMP2 Vaccine in Nasopharyngeal Carcinoma Nasopharyngeal Cancer, Epstein Barr Virus Infections | Phase 1 | 2013-03-01 |
| Terminated | A Phase I Study of AZD0424 Alone and in Combination in Advanced Solid Tumours Advanced Solid Tumours | Phase 1 | 2012-10-01 |
| Completed | Phase I Study of AT13148, a Novel AGC Kinase Inhibitor Advanced Solid Tumours | Phase 1 | 2012-05-01 |
| Completed | A Phase I Trial of Vandetanib (AZD6474) and Selumetinib (AZD6244) for Solid Tumours Including Non Small Cell L Cancer, Non Small Cell Lung Cancer | Phase 1 | 2012-01-10 |
| Completed | AT9283 in Treating Young Patients With Relapsed or Refractory Acute Leukemia Leukemia | Phase 1 | 2011-09-01 |
| Completed | Olaparib and Temozolomide in Treating Patients With Relapsed Glioblastoma Brain and Central Nervous System Tumors | Phase 1 | 2011-07-01 |
| Terminated | NG-Nitro-L-Arginine in Treating Patients With Advanced Solid Tumors Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | 2011-04-01 |
| Completed | Vaccine Therapy, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Mu Brain and Central Nervous System Tumors | Phase 1 | 2010-07-01 |
| Withdrawn | Comparing PET-CT Using C-11 Choline and 18F-Fluoromethylcholine in Patients With Metastatic Prostate Cancer Prostate Cancer | Phase 2 | 2010-05-01 |
| Completed | MK0752 and Gemcitabine Hydrochloride in Treating Patients With Stage III and IV Pancreatic Cancer That Cannot Pancreatic Cancer | Phase 1 | 2010-04-01 |
| Completed | Aurora B/C Kinase Inhibitor GSK1070916A in Treating Patients With Advanced Solid Tumors Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | 2010-03-01 |
| Completed | AT9283 in Children and Adolescents With Relapsed and Refractory Solid Tumors Unspecified Childhood Solid Tumor, Protocol Specific | Phase 1 | 2009-09-01 |
| Unknown | Carmustine, Etoposide, Cytarabine, Melphalan, and Alemtuzumab Followed by Donor Stem Cell Transplant in Treati Lymphoma | Phase 2 | 2009-07-01 |
| Unknown | Fludarabine Phosphate, Melphalan, and Alemtuzumab Followed by Donor Stem Cell Transplant in Treating Patients Lymphoma | Phase 2 | 2009-07-01 |
| Terminated | Technetium Tc 99m Demobesin-4 for Imaging Procedures in Patients With Prostate Cancer Prostate Cancer | Phase 1 | 2009-06-01 |
| Unknown | Donor Umbilical Cord Blood Transplant After Cyclophosphamide, Fludarabine Phosphate, and Total-Body Irradiatio Hematopoietic/Lymphoid Cancer | Phase 2 | 2009-01-01 |
| Withdrawn | Se-Methyl-Seleno-L-Cysteine, Rituximab, Ifosfamide, Carboplatin, and Etoposide in Treating Patients With Diffu Lymphoma | Phase 1 / Phase 2 | 2009-01-01 |
| Unknown | Donor Stem Cell Transplant in Treating Patients With Mantle Cell Lymphoma Lymphoma | Phase 2 | 2008-11-01 |
| Completed | Abiraterone Acetate in Treating Postmenopausal Women With Advanced or Metastatic Breast Cancer Breast Cancer | Phase 1 / Phase 2 | 2008-10-01 |
| Unknown | Study of Blood and Tissue Samples From Patients Receiving Androgen Deprivation for Newly Diagnosed Prostate Ca Prostate Cancer | N/A | 2008-09-01 |
| Terminated | Exemestane With or Without ATN-224 in Treating Postmenopausal Women With Recurrent or Advanced Breast Cancer Breast Cancer | Phase 2 | 2008-06-01 |
| Unknown | Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the Bladder Cancer, Brain and Central Nervous System Tumors, Esophageal Cancer | — | 2008-02-01 |
| Unknown | Study of Genes and Environment in Patients With Breast Cancer in the East Anglia Region of the United Kingdom Breast Cancer | — | 2008-02-01 |
| Unknown | Study of Genes and the Environment in Patients With Ovarian Cancer in the East Anglia, Oxford, Trent, or West Ovarian Cancer | — | 2008-02-01 |
| Unknown | Study of Genes and the Environment in Patients With Colorectal Cancer in the East Anglia Region of the United Colorectal Cancer | — | 2008-02-01 |
| Unknown | Study of Genes and the Environment in Patients With Prostate Cancer Residing in the East Anglia, Trent, or Wes Prostate Cancer | — | 2008-02-01 |
| Unknown | Blood Samples From Healthy Volunteers for Genetic Studies in the East Anglia Region of the United Kingdom Healthy, no Evidence of Disease | — | 2008-02-01 |
| Unknown | High-Dose Chemotherapy Given Together With Peripheral Blood Stem Cell Transplant in Treating Patients With Int Lymphoma, Small Intestine Cancer | Phase 2 | 2008-02-01 |
| Unknown | Study of Genes and the Environment in Patients With Endometrial Cancer in the East Anglia, Oxford, Trent, or W Endometrial Cancer | — | 2008-02-01 |
| Terminated | GSAO in Treating Patients With Advanced Solid Tumors That Have Not Responded to Therapy Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | 2008-01-01 |
| Completed | Rucaparib(CO-338;Formally Called AG-014699 or PF-0136738) in Treating Patients With Locally Advanced or Metast brca1 Mutation Carrier, brca2 Mutation Carrier, Breast Cancer | Phase 2 | 2007-12-01 |
| Completed | Radiation Therapy in Treating Patients With Metastatic Spinal Cord Compression Spinal Cord Compression, Unspecified Adult Solid Tumor, Protocol Specific | N/A | 2007-11-01 |
| Terminated | Boron Phenylalanine With or Without Mannitol in Treating Patients With Glioblastoma Multiforme Brain and Central Nervous System Tumors | Phase 1 | 2007-10-01 |
| Terminated | Treated Blood Cells, Cyclophosphamide, Fludarabine Phosphate, and Aldesleukin in Treating Patients With Cancer Breast Cancer, Colorectal Cancer, Gastric Cancer | Phase 1 | 2007-08-01 |
| Terminated | Carboplatin With or Without Decitabine in Treating Patients With Progressive, Advanced Ovarian Epithelial Canc Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cavity Cancer | Phase 2 | 2007-07-01 |
| Completed | A Phase I Study of the Chimeric Anti-CD40 Monoclonal Antibody ChiLob 7/4 to Treat Advanced Malignancies Refrac Cancer, Neoplasms, Lymphoma | Phase 1 | 2007-07-01 |
| Unknown | Alemtuzumab and Combination Chemotherapy in Treating Patients With Stage I, Stage II, Stage III, or Stage IV P Lymphoma, Small Intestine Cancer | Phase 1 | 2007-05-01 |
| Unknown | Fludarabine, Cyclophosphamide, and Thalidomide in Treating Patients With Angioimmunoblastic T-Cell Lymphoma Lymphoma | Phase 2 | 2006-01-01 |
| Unknown | Combination Chemotherapy and Rituximab in Treating Patients With Diffuse Large B-Cell Non-Hodgkin Lymphoma Lymphoma | Phase 2 | 2006-01-01 |
| Completed | Combination Chemotherapy With or Without Rituximab in Treating Patients With Previously Treated Chronic Lympho Leukemia | Phase 2 | 2005-07-01 |
| Completed | 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Metastatic Malignant Melanoma Melanoma (Skin) | Phase 2 | 2005-03-01 |
| Completed | Vaccine Therapy in Treating Patients With Epstein-Barr Virus-Related Cancer Gastric Cancer, Head and Neck Cancer, Lymphoma | Phase 1 | 2005-03-01 |
| Unknown | Genes and Other Risk Factors for Second Primary Breast Cancer in Women With Breast Cancer and Their Female Fam Breast Cancer | — | 2005-01-01 |
| Completed | Capecitabine and Oxaliplatin or Standard Follow-Up Care in Treating Patients Who Have Undergone Surgery for Lo Colorectal Cancer | Phase 3 | 2004-11-01 |
| Completed | Effect of TroVax in Patients Having Colorectal Cancer With Liver Metastases Removed Colorectal Neoplasms | Phase 2 | 2004-06-01 |
| Completed | Single-Dose Local Radiation Therapy Compared With Ibandronate in Treating Patients With Localized Metastatic B Metastatic Cancer, Pain, Prostate Cancer | Phase 3 | 2003-04-01 |
| Unknown | Study of Blood and Tissue Samples From Patients With Stomach Cancer, Esophageal Cancer, or Gastroesophageal Ju Adenocarcinoma of the Gastroesophageal Junction, Esophageal Cancer, Gastric Cancer | — | 2002-08-01 |
| Completed | Gemcitabine With or Without Capecitabine in Treating Patients With Locally Advanced or Metastatic Pancreatic C Pancreatic Cancer | Phase 3 | 2002-04-01 |
| Unknown | Study of Tissue, Blood, and Urine Samples From Patients With Advanced Prostate Cancer Prostate Cancer | — | 2002-01-01 |
| Unknown | Interferon Alfa With or Without Thalidomide in Treating Patients With Metastatic Kidney Cancer Kidney Cancer | Phase 2 | 2001-02-01 |
| Completed | Suramin in Treating Patients With Recurrent Bladder Cancer Bladder Cancer | Phase 1 | 2000-10-01 |
| Completed | Carboplatin With or Without Thalidomide in Treating Patients With Ovarian Epithelial Cancer Ovarian Cancer | Phase 2 | 1999-08-01 |
| Completed | Bryostatin 1 In Treating Patients With Progressive Kidney Cancer Kidney Cancer | Phase 2 | 1999-03-01 |
| Completed | Geldanamycin Analogue in Treating Patients With Advanced Cancer Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | 1998-08-01 |
| Unknown | Combination Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer Lung Cancer | Phase 3 | 1998-05-01 |
| Completed | Study of DMXAA (Now Known as ASA404) in Solid Tumors Solid Tumors | Phase 1 | 1996-05-01 |
| Completed | Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Head and Neck Cancer Head and Neck Cancer | Phase 3 | 1990-01-01 |
| Unknown | Adjuvant Hormone Therapy in Treating Women With Operable Breast Cancer Breast Cancer | Phase 3 | 1987-09-01 |