NCT00757991

Blood Samples From Healthy Volunteers for Genetic Studies in the East Anglia Region of the United Kingdom

A Population Based Control Collection for Genetic Studies in East Anglia

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 4,000 (estimated)
• Sponsor: Cancer Research UK · Academic / Other
• Sex: All
• Age: 35 Years – 69 Years
• Healthy volunteers: Accepted

Summary

RATIONALE: Studying samples of blood from healthy volunteers in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This study is looking at genetic susceptibility to cancer and interactions between genes and the environment in healthy volunteers.

Detailed description

OBJECTIVES: * To obtain blood samples and simple epidemiological information on a population-based series of adult individuals without cancer. * To establish whether polymorphisms in putative cancer predisposition genes are associated with an increased risk of cancer by comparing the frequency of alterations in these genes with the corresponding frequency in a comparable series of cancer patients. * To examine the interactions between genetic and non-genetic risk factors. OUTLINE: This is a multicenter study. Participants complete a simple epidemiological questionnaire. Participants undergo blood sample collection. DNA is extracted from these samples for polymorphism analysis of low penetrance cancer susceptibility genes in the following related clinical trials: MREC-SEARCH-CANCER, MREC-SEARCH-PROSTATE, and MREC-SEARCH-BREAST. They may also be used in the analyses of the following related clinical trials: MREC-SEARCH-OVARIAN, MREC-SEARCH-ENDOMETRIAL, MREC-SEARCH-COLORECTAL. PROJECTED ACCRUAL: A total of 2,000 male and 2,000 female participants will be accrued for this study.

Conditions

• Healthy, no Evidence of Disease

Interventions

Type	Name	Description
GENETIC	polymorphism analysis
OTHER	laboratory biomarker analysis
OTHER	questionnaire administration

Timeline

• Start date: 2008-02-01
• First posted: 2008-09-23
• Last updated: 2013-08-26

Locations

1 site across 1 country: United Kingdom