| Not Yet Recruiting | Quantification of Systemic Congestion by Ultrasound As a Predictor of Weaning Failure From Mechanical Ventilat NCT07343882 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | N/A |
| Not Yet Recruiting | Characterization of Weaning Practices in ICUs of Global South Countries NCT07337408 | Hospital do Coracao | — |
| Recruiting | Shorter Weaning From Invasive Ventilation With Levosimendan NCT07105202 | Radboud University Medical Center | Phase 4 |
| Completed | Temporal Change in Parasternal Thickening Fraction as a Predictor for Weaning NCT07083128 | Cairo University | — |
| Recruiting | Surface Electrical Myography, Oxygen Consumption, Effort, and Weaning in the Mechanically Ventilated Patient i NCT07109570 | Leiden University Medical Center | — |
| Recruiting | PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients NCT06716463 | Unity Health Toronto | — |
| Recruiting | Role of Regional Lung Compliance and Dynamic Transpulmonary Driving Pressure in the Liberation Difficulty in T NCT07003672 | National Taiwan University Hospital | — |
| Completed | Can Total Mechanical Power Be a Determinant of Weaning Failure in Chronic Obstructive Pulmonary Disease (COPD) NCT06751654 | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | — |
| Recruiting | Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients NCT06683781 | Hospital Italiano de Buenos Aires | — |
| Recruiting | Evaluation of heepSync, a Novel Algorithm for Transcutaneous Electrical Stimulation of Respiratory Muscles in NCT07363902 | Tesai Care SL | N/A |
| Completed | Role of Spectrophotometer in Early Prediction of Weaning Induced Cardiac Dysfunction NCT06674824 | Ain Shams University | — |
| Recruiting | Effect of Hypophosphatemia on Neuro-excursion Efficiency During Mechanical Ventilator Weaning NCT06754670 | Peking Union Medical College | — |
| Active Not Recruiting | TESTO-TRIAL: Use of Testosterone in Critically Ill Patients NCT06592144 | Leticia Maria Defendi Barboza Marson | Phase 4 |
| Recruiting | Exploration of Mechanisms for Weaning Failure NCT06424314 | The First Affiliated Hospital of Guangzhou Medical University | — |
| Not Yet Recruiting | Preventing Celiac Disease by Weaning With Mediterranean Diet NCT06184906 | University of Naples | Phase 3 |
| Not Yet Recruiting | The Effect of Quantitative EEG Combined With Ultrasound and Sputum Volume on Predicting Weaning Failure NCT06359977 | Qingdao University | — |
| Recruiting | Extremes of Respiratory Effort in Weaning Failure From Mechanical Ventilation: a Prospective Observational Stu NCT06464224 | Universidade Federal do Rio de Janeiro | — |
| Completed | Preventing Failed Extubations NCT06301867 | Duke University | — |
| Recruiting | Oxygen Consumption (VO2), Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Uni NCT06391424 | Leiden University Medical Center | — |
| Unknown | Monitoring of Breathing Effort Through Pressure Time Product Measurement Using Airway Occlusion Pressure NCT06040138 | Hospital Italiano de Buenos Aires | — |
| Recruiting | Predictive Value of Airway Occlusion Pressure, Maximal Inspiratory Pressure and Their Ratio for Successful Ext NCT06627686 | Benha University | — |
| Unknown | Predictive Value of Chest Ultrasound Observation on Extubation Failure NCT05944588 | University Hospital, Caen | — |
| Completed | Weaning With Tracheostomy - an Observational Study on Patient-centered Outcomes NCT05906888 | Henrik Endeman | — |
| Unknown | P0.1 and Extubation Failure in Critically Ill Patients NCT05802745 | Cleveland Clinic Abu Dhabi | — |
| Unknown | HVNI for Successful Weaning in Respiratory Failure NCT05855213 | Alexandria University | N/A |
| Completed | Critical Care Ultrasound Guided Weaning NCT05763134 | Antalya Training and Research Hospital | — |
| Unknown | Evaluation of Regional Ventilation Distribution Using Electrical Impedance Tomography During Weaning From Mech NCT05726513 | Università degli Studi di Ferrara | N/A |
| Recruiting | Improving Our Understanding of Respiratory Muscle Training to Facilitate Weaning From Mechanical Ventilation i NCT04658498 | KU Leuven | N/A |
| Completed | Lung Volume Preservation During Extubation NCT05526053 | Althaia Xarxa Assistencial Universitària de Manresa | N/A |
| Completed | A Modified Cuff Leak Test and Reintubation in Mechanically Ventilated Patients NCT05550220 | Beijing Chao Yang Hospital | N/A |
| Unknown | Evaluation of a Combined Model in Predicting Weaning Outcome in Critically Ill Patients. NCT05431036 | Assiut University | — |
| Completed | Comprehensive Ultrasound Evaluation as a Predictor of Weaning NCT05539599 | Università degli Studi di Ferrara | — |
| Unknown | Value of Diaphragm Function Predicting Weaning From Mechanical Ventilation NCT05632822 | Peking Union Medical College Hospital | — |
| Active Not Recruiting | The Value of Repeated BIOMarker Measurements During an SBT to Predict EXtubation Failure in ICU Patients NCT05637099 | Henrik Endeman | — |
| Completed | Comparison of Weaning Parameters and Diaphragm Thickness Changes NCT06967623 | Tarık Durna | — |
| Recruiting | Estimation of the Diaphragm Electrical Activity and Intercostal Thickening Fraction During Different Pattern o NCT05990348 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Unknown | Development of a Multimodal Index to Improve the Predictive Value of Success in Weaning From Mechanical Ventil NCT04554095 | Corporacion Parc Tauli | — |
| Unknown | Negative Pressure Ventilation in Paediatric Patients During Weaning NCT05035290 | Brno University Hospital | N/A |
| Unknown | Fluid unLoading On Weaning (FLOW) NCT04496583 | Pontificia Universidad Catolica de Chile | N/A |
| Unknown | Diastolic dYsfunctioN AssessMent in critICally Ill Patients NCT04584203 | Humanitas Clinical and Research Center | — |
| Unknown | Can High Intensity Inspiratory Muscle Training Improve Inspiratory Muscle Strength and Accelerate Weaning in M NCT04347317 | Hospital Universitari Vall d'Hebron Research Institute | N/A |
| Completed | Ultrasound-Assessed Diaphragmatic Dysfunction as a Predictor of Weaning Outcome NCT04825509 | Ain Shams University | — |
| Completed | Determinants of Successful Decannulation in Difficult-to-wean Patients NCT04841889 | Hopital Forcilles | N/A |
| Completed | Speeding the Weaning up: Aggressive Screening Criteria and Higher Minimal Ventilatory Settings. NCT04758546 | Gonzalo Hernandez Martinez | N/A |
| Unknown | The Effect of High Flow Oxygen Therapy Via Tracheostomy on Diaphragm Function NCT04758910 | Evangelismos Hospital | N/A |
| Completed | Respiratory Drive and Inspiratory Effort in COVID-19 Associated ARDS NCT06224010 | University of Turin, Italy | — |
| Completed | Left Ventricular Diastolic Dysfunction as a Predictor of Weaning Failure From Mechanical Ventilation NCT04703387 | Tanta University | — |
| Completed | Role of Non-invasive Mechanical Ventilation and Diuretics in Improving Weaning Outcome of Patients With High L NCT05617989 | Ain Shams University | — |
| Unknown | One-Year Quality of Life and Functional Prognosis of COVID-19 Patients in Post-ICU Setting NCT04373811 | Fondation Hôpital Saint-Joseph | — |
| Completed | Predictors of Prognosis in Patients With Critical Illness. NCT04914065 | Taoyuan General Hospital | — |
| Completed | Incidence and Risk Factors of Weaning-induced Cardiac Dysfunction: Results From a Multicenter, Observational S NCT05318261 | Bicetre Hospital | — |
| Completed | Peripheral Perfusion Index in Weaning From Mechanical Ventilation NCT03974568 | Cairo University | — |
| Unknown | The Effect of Doxapram Versus Theophylline on Diaphragmatic Function NCT03894189 | Beni-Suef University | N/A |
| Terminated | Comparison of Two Extubation Techniques in Critically Ill Adult Patients NCT03918811 | Hospital Donación Francisco Santojanni | N/A |
| Unknown | Breathing Pattern, WOB and Gas Exchange in Patients With Acute Respiratory Distress Syndrome During the Sponta NCT04209270 | Sanatorio de la Trinidad Mitre | — |
| Unknown | Lung Ultrasound for Predicting Outcome of Weaning From Mechanical Ventilation NCT03880864 | Ain Shams University | Phase 1 |
| Completed | Voices of Patients' Relatives to Support Weaning From Mechanical Ventilation NCT03795623 | University of Erlangen-Nürnberg Medical School | N/A |
| Completed | Weaning From Nasal High Flow Therapy NCT05210881 | Hôpital Louis Mourier | — |
| Unknown | The Relationship Between Trans-diaphragmatic Pressure and Diaphragmatic Contraction NCT03802383 | University of Thessaly | — |
| Completed | Ultrasound Study of the Diaphragm Evolution Under ECMO NCT03736239 | Association Pro-arte | — |
| Completed | Electromyography for Diaphragm Effort NCT03580720 | Amsterdam UMC, location VUmc | N/A |
| Unknown | Preoperative Exercise Test and Postoperative Intensive Care Unit Need in Bariatric Surgery NCT03419104 | Istanbul University | N/A |
| Completed | Ultrasound-Guided Diaphragmatic Thickness Assessment as an Indicator of Successful Extubation in Mechanically NCT03894436 | National Cancer Institute, Egypt | — |
| Completed | Diaphragmatic Rapid Shallow Breathing Index for Predicting Weaning Outcome From Mechanical Ventilation NCT03561792 | Zagazig University | N/A |
| Completed | Inspiratory Muscle Training in Difficult to Wean Patients NCT03240263 | KU Leuven | N/A |
| Completed | NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients NCT06332768 | Northern State Medical University | N/A |
| Unknown | Abdominal Muscle Thickness in Mechanically Ventilated Patients NCT03567564 | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | — |
| Unknown | Interest of High Flow Nasal Cannula Oxygen Therapy in Pediatric Intensive Care Unit NCT03505814 | Hôpital d'enfants Béchir-Hamza | N/A |
| Completed | Impact of the Inspiratory Cortical Control on the Outcome of the Ventilatory Weaning Test in Patients Intubate NCT03372252 | Poitiers University Hospital | N/A |
| Unknown | The Clinical Study of Bundle Measures to Improve the Success Rate of Patients With Difficult Ventilator Weanin NCT03436095 | Shenzhen Second People's Hospital | — |
| Completed | Weaning From Noninvasive Ventilation NCT02845076 | Baskent University | N/A |
| Completed | Sedation and Ease of Weaning From Mechanical Ventilation NCT03406936 | Assiut University | N/A |
| Completed | Hand Grip Strength and Medical Research Council Scale as Predictors of Weaning Failure NCT03991702 | Hospital de Clinicas de Porto Alegre | — |
| Completed | Two Opposite Strategies of Weaning From Mechanical Ventilation NCT02620358 | Althaia Xarxa Assistencial Universitària de Manresa | N/A |
| Unknown | Predictive Analysis Software for Successful Weaning From Ventilator of Patients NCT02915458 | Chang Gung Memorial Hospital | — |
| Completed | The Validity of Maximal Diaphragm Thickening Fraction to Measure Diaphragm Function in Mechanically Ventilated NCT03129217 | University Health Network, Toronto | — |
| Completed | Lung Impedetiometric Modification in SBT and Extubation Failure NCT03894332 | University Magna Graecia | — |
| Unknown | VentFree: A Novel Abdominal Stimulator to Assist With Ventilator Weaning NCT02224352 | Edward Hines Jr. VA Hospital | N/A |
| Completed | Impact of Nasal High-flow vs Venturi Mask Oxygen Therapy on Weaning Outcome: a Multicenter, Randomized, Contro NCT02107183 | Catholic University of the Sacred Heart | N/A |
| Completed | Rest After Spontaneous Breathing Trial for Prevention of Post-extubation Failure NCT01915563 | Althaia Xarxa Assistencial Universitària de Manresa | N/A |
| Completed | Utility of a Weaning Protocol in ICU NCT01877850 | ELENA PELI,MD | — |
| Completed | Volume Responsiveness Before SBT Predicts the Outcome of Mechanical Ventilation Weaning in Critically Ill Pati NCT01867853 | Southeast University, China | — |
| Unknown | Effects of Levosimendan on Diaphragm Function in Mechanically Ventilated Patients NCT01721434 | University Medical Center Nijmegen | Phase 2 / Phase 3 |
| Completed | Weaning From Mechanical Ventilation: Spontaneous Breathing Trial and the Assessment of Work of Breathing NCT01928277 | University of Tromso | — |
| Unknown | Study of Variables Related to the Discontinuation of Mechanical Ventilation in Patients With Head Injury NCT01713010 | Federal University of Uberlandia | — |
| Completed | Comparison of Two Ventilator Mode During the Night: New Strategy of Mechanical Ventilation Weaning NCT01573481 | Centre Hospitalier Universitaire, Amiens | N/A |
| Completed | Comparison of Two Different Types of Mechanical Ventilation Weaning in Patients in the ICU NCT02122016 | Hospital Israelita Albert Einstein | Phase 4 |
| Unknown | Changes of Weaning Parameter in Weaning Failure Patient After Tracheostomy as a Predictor of Subsequent Weanin NCT01312142 | National Taiwan University Hospital | — |
| Completed | Evaluation of a Systematic Approach to Weaning From Mechanical Ventilation NCT01482429 | Federal University of Uberlandia | N/A |
| Completed | Pressure Support Ventilation Versus Neurally Adjusted Ventilatory Assist in Difficult to Wean Pediatric Patien NCT04360590 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |