NCT06359977

The Effect of Quantitative EEG Combined With Ultrasound and Sputum Volume on Predicting Weaning Failure

The Effect of Quantitative Electroencephalography Combined With Ultrasound and Sputum Volume on Predicting Weaning Failure in Neurocritical Patients

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Qingdao University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Neurocritical patients often face the need for removal of endotracheal tubes. However, despite following the extubation criteria for general critical ill patients, neurocritical patients still exhibit a higher rate of weaning failure, significantly higher than that of general critical ill patients. The extubation criteria for general critical patients emphasize the assessment of lung conditions. However, neurological critical patients often have less severe lung damage, but factors such as consciousness level and coughing ability may significantly influence extubation. Quantitative EEG serves as an objective tool to reflect consciousness level status, while bedside ultrasound can assess respiratory muscle function. Additionally, sputum volume may reflect the condition of lung condition. Therefore, we believe that combination of these three indicators can better predict the success of extubation for neurocritical patients.

Conditions

• Weaning Failure

Interventions

Type	Name	Description
OTHER	Quantitative EEG monitoring and beside ultrasound evaluation	After successful spontaneous breathing trial, neurocritical patients undergo at least 2 hours of quantitative EEG monitoring before extubation. Additionally, bedside ultrasound assesses the thickness and variability of the diaphragm, intercostal muscles, rectus abdominis, transversus abdominis, and external oblique muscles. The sputum volume for the 24 hours prior to extubation is also recorded. Reintubation within 48 hours after extubation is defined as weaning failure.

Timeline

• Start date: 2024-04-15
• Primary completion: 2025-04-15
• Completion: 2025-05-15
• First posted: 2024-04-11
• Last updated: 2024-04-11