NCT07083128

Temporal Change in Parasternal Thickening Fraction as a Predictor for Weaning

Temporal Changes in Parasternal Intercostal Muscle Thickening as a Possible Biomarker for Successful Weaning From Mechanical Ventilation: a Prospective Observational Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 64 (actual)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

optimal time to liberate from mechanical ventilation is highly prioritized since improper extubation time lead to serious consequences

Detailed description

Several parameters were proposed to assess proper weaning time including diaphragmatic ultrasound and extra-diaghragmatic muscles. previous research concluded an ability of parasternal intercostal (PIC) thickening to predict weaning outcomes. researchers of current study assumed that temporal changes in PIC thickening would provide greater ability to predict weaning outcomes

Conditions

• Mechanical Ventilation
• Weaning From Mechanical Ventilation
• Weaning Failure

Interventions

Type	Name	Description
DEVICE	Parasternal intercostal thickening	Temporal change in parasternal intercostal thickening fraction at initiation and 30 minutes of spontaneous breathing trial

Timeline

• Start date: 2025-07-13
• Primary completion: 2026-03-20
• Completion: 2026-03-20
• First posted: 2025-07-24
• Last updated: 2026-03-25

Locations

1 site across 1 country: Egypt